6-(2-((2-fluorophenyl)ethynyl)phenyl)-5-hexyn-1-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-(2-((2-fluorophenyl)ethynyl)phenyl)-5-hexyn-1-ol
• 英文别名: 6-[2-[2-(2-Fluorophenyl)ethynyl]phenyl]hex-5-yn-1-ol
• 化学式: C₂₀H₁₇FO
• 分子量: 292.353
• InChiKey: GYVWWKYIVZFMML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氟碘苯 、 6-(2-((trimethylsilyl)ethynyl)phenyl)-5-hexynol 在 四(三苯基膦)钯 甲醇 、 copper(l) iodide 、 potassium carbonate 作用下， 反应 6.0h， 以82%的产率得到6-(2-((2-fluorophenyl)ethynyl)phenyl)-5-hexyn-1-ol
  参考文献：
  名称：

  Novel acyclic enediynes inhibit Cyclin A and Cdc25C expression and induce apoptosis phenomenon to show potent antitumor proliferation

  摘要：

  A series of acyclic enediynes showing significant inhibition on the growth of tumor cancer is disclosed. To investigate the structure-activity relationship, compounds 12-33 were synthesized. Among them, compound 17 showed most potent growth inhibition activity against all tumor cell lines at low concentration, such as SR (0.4 mu M) and MDA-MB-435 (0.8 mu M), and almost completely blocked cell cycle in G2/M phase via controlling Cyclin A and Cdc25C expression. On the other hand, compound 29 showed potent induced apoptosis activity by inducing activation of caspase-3, -8, and -9. Thus, this article disclosed a new multiple-protein regulator in cell cycle regulation and induced apoptosis to achieve the goal of anticancer drug. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.04.024

文献信息

• Novel acyclic enediynes inhibit Cyclin A and Cdc25C expression and induce apoptosis phenomenon to show potent antitumor proliferation
  作者：Yu-Hsiang Lo、I-Ling Lin、Chi-Fong Lin、Cheng-Chung Hsu、Sheng-Huei Yang、Shinne-Ren Lin、Ming-Jung Wu

  DOI：10.1016/j.bmc.2007.04.024

  日期：2007.7

  A series of acyclic enediynes showing significant inhibition on the growth of tumor cancer is disclosed. To investigate the structure-activity relationship, compounds 12-33 were synthesized. Among them, compound 17 showed most potent growth inhibition activity against all tumor cell lines at low concentration, such as SR (0.4 mu M) and MDA-MB-435 (0.8 mu M), and almost completely blocked cell cycle in G2/M phase via controlling Cyclin A and Cdc25C expression. On the other hand, compound 29 showed potent induced apoptosis activity by inducing activation of caspase-3, -8, and -9. Thus, this article disclosed a new multiple-protein regulator in cell cycle regulation and induced apoptosis to achieve the goal of anticancer drug. (c) 2007 Elsevier Ltd. All rights reserved.