申请人:Pfizer Inc.
公开号:US07919506B2
公开(公告)日:2011-04-05
Dibenzyl amine compounds and derivatives, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.
二苯甲胺化合物及其衍生物,含有这些化合物的药物组成物和使用这些化合物升高特定血浆脂质水平,包括高密度脂蛋白胆固醇并降低其他某些血浆脂质水平,如低密度脂蛋白胆固醇和三酰甘油,因此用于治疗由低高密度脂蛋白胆固醇水平和/或高低密度脂蛋白胆固醇和三酰甘油水平恶化的疾病,如动脉粥样硬化和心血管疾病在某些哺乳动物中,包括人类。