1-chloro-4-hydroxy-3-(2-adamantyl)benzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-chloro-4-hydroxy-3-(2-adamantyl)benzene
• 英文别名: 2-(2-Adamantyl)-4-chlorophenol
• 化学式: C₁₆H₁₉ClO
• 分子量: 262.779
• InChiKey: NRJRKPHTMZUGBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-chloro-4-hydroxy-3-(2-adamantyl)benzene 、 1-甲基-5-硝基-1H-咪唑-2-甲醛 在 双氧水 、 丙酸 、 苯硼酸 作用下， 生成 2-(2-Adamantyl)-4-chloro-6-[hydroxy-(1-methyl-5-nitroimidazol-2-yl)methyl]phenol
  参考文献：
  名称：

  Preparation, antimicrobial evaluation and mutagenicity of differently substituted [2-hydroxyaryl]-[1-methyl-5-nitro-1H-2-imidazolyl]methanols

  摘要：

  An efficient preparation of the titled compounds is described, their antimicrobial activity and mutagenic properties being evaluated. Some of the studied compounds are non mutagenic and present a MIC as low as some of the usual standards in the field. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00317-4
• 作为产物：
  描述：

  对氯苯酚 、 金刚烷双吖丙啶 在 硫酸 作用下， 以 四氯化碳 为溶剂， 反应 1.0h， 以24%的产率得到1-chloro-4-hydroxy-3-(2-adamantyl)benzene
  参考文献：
  名称：

  Isaev, S. D.; Zhalnina, G. G.; Murzinova, Z. N., Journal of Organic Chemistry USSR (English Translation), 1988, vol. 24, p. 126 - 131

  摘要：

  DOI：

文献信息

• Non-Catalyzed C-Alkylation of Phenols With Cyclic Secondary Alkyl Bromides
  作者：Yolanda Arredondo、Marcial Moreno-Mañas、Roser Pleixats

  DOI：10.1080/00397919608003808

  日期：1996.11

  Abstract C-Alkylations of phenol with 1-chloro and 1-bromoadamantane, 2-bromoadamantane, cyclohexyl bromide and exo-2-bromonorbornane, and C-alkylations of para-substituted phenol derivatives with 2-bromoadamantane are described.

  摘要 描述了苯酚与 1-氯和 1-溴金刚烷、2-溴金刚烷、环己基溴和外型 2-溴降冰片烷的 C-烷基化，以及对位取代的苯酚衍生物与 2-溴金刚烷的 C-烷基化。
• Preparation, antimicrobial evaluation and mutagenicity of differently substituted [2-hydroxyaryl]-[1-methyl-5-nitro-1H-2-imidazolyl]methanols
  作者：Y. Arredondo、M. Moreno-Mañas、R. Pleixats、C. Palacín、M.M. Raga、J.M. Castelló、J.A. Ortiz

  DOI：10.1016/0960-894x(96)00317-4

  日期：1996.8

  An efficient preparation of the titled compounds is described, their antimicrobial activity and mutagenic properties being evaluated. Some of the studied compounds are non mutagenic and present a MIC as low as some of the usual standards in the field. Copyright (C) 1996 Elsevier Science Ltd
• Preparation, antimicrobial evaluation, and mutagenicity of [2-hydroxyaryl]-[1-methyl-5-nitro-1H-2-imidazolyl]methanols, [5-tert-Butyl-2-methylaminophenyl]-[1-methyl-5-nitro-1H-2-imidazolyl]methanol, and [2-Hydroxyaryl]-[1-methyl-5-nitro-1H-2-imidazolyl] ketones
  作者：Y. Arredondo、M. Moreno-Mañas、R. Pleixats、C. Palacín、M.M. Raga、J.M. Castelló、J.A. Ortiz

  DOI：10.1016/s0968-0896(97)00138-7

  日期：1997.10

  Efficient preparations of the titled compounds are described, their antimicrobial activity and mutagenic properties being evaluated. Some of the studied compounds are nonmutagenic and present a MIC as low as some of the usual standards in the field. (C) 1997 Elsevier Science Ltd.
• Isaev, S. D.; Zhalnina, G. G.; Murzinova, Z. N., Journal of Organic Chemistry USSR (English Translation), 1988, vol. 24, p. 126 - 131
  作者：Isaev, S. D.、Zhalnina, G. G.、Murzinova, Z. N.、Lastovenko, S. I.、Yurchenko, A. G.

  DOI：——

  日期：——