2-cyclohexyl-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane 2-oxide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: 2-cyclohexyl-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane 2-oxide
• 英文别名: 2-Cyclohexyl-4,4,5,5-tetramethyl-1,3,2lambda5-dioxaphospholane 2-oxide；2-cyclohexyl-4,4,5,5-tetramethyl-1,3,2λ5-dioxaphospholane 2-oxide
• 化学式: C₁₂H₂₃O₃P
• 分子量: 246.287
• InChiKey: UIDOORUCJFHYSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4,4,5,5-tetramethyl<1,3,2>dioxaphospholane-2-oxide 、 环己烯 在 2-双环己基膦-2',6'-二甲氧基联苯 、 palladium diacetate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 12.0h， 以70%的产率得到2-cyclohexyl-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane 2-oxide
  参考文献：
  名称：

  钯催化链烷烃与膦酸二烷基酯的羰基化羰基化反应

  摘要：

  AbstractThe palladium‐catalyzed hydrophosphonylation of alkenes with previously unreactive acyclic dialkyl H‐phosphonates has been developed. A catalyst system based on palladium/DavePhos or palladium/SPhos enables the transformation of various alkenes to phosphonates in moderate to good yields and with excellent levels of regioselectivity. Hydrophosphonylations with internal, disubstituted and/or unactivated alkenes are also reported.magnified image

  DOI：

  10.1002/adsc.201400190

文献信息

• Processes for the preparation of phosphonic esters
  申请人：——

  公开号：US20030105345A1

  公开（公告）日：2003-06-05

  The present invention relates to a new manufacturing method for phosphonate esters, which have utility as a carbon-carbon binding formation agent, as well as a synthesis intermediate for biologically active substances such as medical drugs and agri-chemicals. Specifically the present invention relates to a new industrially advantageous manufacturing method for phosphonate esters in which the phosphonate esters of the subject can be efficiently obtained with a high yield rate through a simple operation while having barely any side reaction or sub-product. More specifically, the present invention pertains to a manufacturing method for phosphonate esters in which secondary phosphonate esters and alkene compounds are reacted in a transition metal medium. In addition the present invention relates to a new manufacturing method for allylphosphonate esters in which secondary cyclic phosphonate esters and 1,3-diene compounds are reacted in a palladium medium.

  本发明涉及一种新的膦酸酯制造方法，膦酸酯可用作碳碳结合形成剂，也可用作生物活性物质（如医疗药物和农用化学品）的合成中间体。 具体地说，本发明涉及一种新的具有工业优势的膦酸酯制造方法，在该方法中，可以通过简单的操作以高产率有效地获得主题的膦酸酯，同时几乎没有任何副反应或副产品。 更具体地说，本发明涉及一种膦酸酯的制造方法，其中仲膦酸酯和烯化合物在过渡金属介质中发生反应。此外，本发明还涉及一种烯丙基膦酸酯的新制造方法，其中仲环膦酸酯和 1，3-二烯化合物在钯介质中发生反应。
• Method for manufacturing phosphonate esters
  申请人：——

  公开号：US20040220422A1

  公开（公告）日：2004-11-04

  The present invention relates to a new manufacturing method for phosphonate esters, which have utility as a carbon-carbon binding formation agent, as well as a synthesis intermediate for biologically active substances such as medical drugs and agri-chemicals. Specifically the present invention relates to a new industrially advantageous manufacturing method for phosphonate esters in which the phosphonate esters of the subject can be efficiently obtained with a high yield rate through a simple operation while having barely any side reaction or sub-product. More specifically, the present invention pertains to a manufacturing method for phosphonate esters in which secondary phosphonate esters and alkene compounds are reacted in a transition metal catalyst. In addition the present invention relates to a new manufacturing method for allylphosphonate esters in which secondary cyclic phosphonate esters and 1,3-diene compounds are reacted in a palladium catalvst.

  本发明涉及一种新的膦酸酯制造方法，膦酸酯可用作碳碳结合形成剂，也可用作生物活性物质（如医疗药物和农用化学品）的合成中间体。 具体地说，本发明涉及一种新的具有工业优势的膦酸酯制造方法，在该方法中，可以通过简单的操作以高产率有效地获得主题的膦酸酯，同时几乎没有任何副反应或副产品。 更具体地说，本发明涉及一种膦酸酯的制造方法，其中仲膦酸酯和烯化合物在过渡金属催化剂中发生反应。此外，本发明还涉及一种新的烯丙基膦酸酯制造方法，其中仲环膦酸酯和 1,3 二烯化合物在钯催化剂中发生反应。
• High Reactivity of a Five-Membered Cyclic Hydrogen Phosphonate Leading to Development of Facile Palladium-Catalyzed Hydrophosphorylation of Alkenes
  作者：Li-Biao Han、Farzad Mirzaei、Chang-Qiu Zhao、Masato Tanaka

  DOI：10.1021/ja000444v

  日期：2000.6.1
• PROCESSES FOR THE PREPARATION OF PHOSPHONIC ESTERS
  申请人：Japan Science and Technology Agency

  公开号：EP1195380B1

  公开（公告）日：2004-07-14
• US6765107B2
  申请人：——

  公开号：US6765107B2

  公开（公告）日：2004-07-20