2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluoro-1-octyl 4-(11-trichlorosilyl-1-oxoundecyl oxymethyl)-3-nitrobenzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluoro-1-octyl 4-(11-trichlorosilyl-1-oxoundecyl oxymethyl)-3-nitrobenzoate
• 英文别名: 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluoro-1-octyl 4-(11-trichlorosilyl-1-oxoundecyloxymethyl)-3-nitrobenzoate；3-Nitro-4-[1-oxo-11-(trichlorosilyl)undecyloxymethyl]benzoic acid 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluorooctyl ester；2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluorooctyl 3-nitro-4-(11-trichlorosilylundecanoyloxymethyl)benzoate
• 化学式: C₂₇H₂₇Cl₃F₁₅NO₆Si
• 分子量: 880.935
• InChiKey: CXJVXDACDGEKPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.34
• 重原子数：
  53
• 可旋转键数：
  22
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  98.4
• 氢给体数：
  0
• 氢受体数：
  21

反应信息

• 作为产物：
  描述：

  2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-十五氟辛-1-醇 在 4-二甲氨基吡啶 、 dihydrogen hexachloroplatinate 、 sodium hydroxide 、 三氯硅烷 、 N,N'-二环己基碳二亚胺 作用下， 以 六甲基磷酰三胺 、 二氯甲烷 、 异丙醇 为溶剂， 反应 2.0h， 生成 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluoro-1-octyl 4-(11-trichlorosilyl-1-oxoundecyl oxymethyl)-3-nitrobenzoate
  参考文献：
  名称：

  Principles of Surface-Directed Liquid Flow in Microfluidic Channels

  摘要：

  为了引导微通道内的液体流动，使用自组装单层膜（SAMs）结合多流层流法或光刻法对表面自由能进行了图案化。在光刻法中，设计并合成了两种可光刻的 SAM。通过接触角和 X 射线光电子能谱分析证实了这一点。使用上述任一种图案化方法，我们都表明，只有当压力保持在临界值以下时，水性液体才会沿着亲水通道流动；液体被称为被虚拟壁限制。我们通过分析得出了液体在表面图案通道中流动的几条原理，并通过实验进行了验证。这些原理包括：虚拟壁可承受的最大压力、可支持自发流动的亲水通道临界宽度、外部压力下液流的最小宽度、可引入亲水通道而液体不会越过亲水-疏水边界的临界曲率半径，以及在最大压力下两股液流保持分离的最小距离。实验结果与分析预测结果十分吻合。

  DOI：

  10.1021/ac020269w

文献信息

• Control and Applications of Immiscible Liquids in Microchannels
  作者：Bin Zhao、Neil O. L. Viernes、Jeffrey S. Moore、David J. Beebe

  DOI：10.1021/ja025835j

  日期：2002.5.1

  Photolithography was used in combination with photocleavable self-assembled monolayers to pattern surface free energies inside microchannels enabling the control of the boundary between immiscible liquids. While aqueous solutions are confined to the hydrophilic pathways by surface forces alone, organic liquids are confined to the hydrophobic region only if the aqueous liquid first occupies the hydrophilic region. In this way, stable liquid boundaries between immiscible liquids are possible as long as the pressures are maintained below critical values. The maximum pressures are determined by the interfacial tension of the aqueous solution and organic liquid, channel depth, and advancing contact angle (theta;(a)). Experimental results on maximum pressures are in good agreement with the analytical values. The ability to confine and position the boundary between immiscible liquids inside microchannels leads to a broad range of applications in microfluidic systems, which is exemplified by fabrication of a semipermeable membrane in a surface-patterned channel via interfacial polymerization.
• Principles of Surface-Directed Liquid Flow in Microfluidic Channels
  作者：Bin Zhao、Jeffrey S. Moore、David J. Beebe

  DOI：10.1021/ac020269w

  日期：2002.8.1

  To direct liquid flow inside microchannels, surface free energies were patterned by use of self-assembled monolayers (SAMs) in combination with either multistream laminar flow or photolithography. For the photolithographic method, two photocleavable SAMs were designed and synthesized. Carboxylic acid-terminated monolayers were obtained by photodeprotection, which was confirmed by contact angle and X-ray photoelectron spectroscopy. Using either of these patterning methods, we show that aqueous liquids flow only along the hydrophilic pathways when the pressure is maintained below a critical value; the liquids are referred to as being confined by virtual walls. Several principles of liquid flow in surface-patterned channels were derived analytically and verified experimentally. These principles include the maximum pressure that virtual walls can withstand, the critical width of the hydrophilic pathway that can support spontaneous flow, the smallest width of the liquid streams under an external pressure, the critical radius of curvature of turns that can be introduced into the hydrophilic pathway without liquid crossing the hydrophilic−hydrophobic boundary, and the minimal distance for two liquid streams to remain separated under the maximum pressure. Experimental results are in good agreement with the analytical predictions.

  为了引导微通道内的液体流动，使用自组装单层膜（SAMs）结合多流层流法或光刻法对表面自由能进行了图案化。在光刻法中，设计并合成了两种可光刻的 SAM。通过接触角和 X 射线光电子能谱分析证实了这一点。使用上述任一种图案化方法，我们都表明，只有当压力保持在临界值以下时，水性液体才会沿着亲水通道流动；液体被称为被虚拟壁限制。我们通过分析得出了液体在表面图案通道中流动的几条原理，并通过实验进行了验证。这些原理包括：虚拟壁可承受的最大压力、可支持自发流动的亲水通道临界宽度、外部压力下液流的最小宽度、可引入亲水通道而液体不会越过亲水-疏水边界的临界曲率半径，以及在最大压力下两股液流保持分离的最小距离。实验结果与分析预测结果十分吻合。