tetraethyl (1,1-difluoropropane-1,3-diyl)bis(phosphonate)

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: tetraethyl (1,1-difluoropropane-1,3-diyl)bis(phosphonate)
• 英文别名: Tetraethyl 1,1-difluorotrimethylene-1,3-bisphosphonate；1,3-Bis(diethoxyphosphoryl)-1,1-difluoropropane
• 化学式: C₁₁H₂₄F₂O₆P₂
• 分子量: 352.252
• InChiKey: WPXGBKCNDWMARO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  21
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  二氟甲基膦酸二乙酯 、 乙烯基磷酸二乙酯 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 环己烷 为溶剂， 反应 1.75h， 以32%的产率得到tetraethyl (1,1-difluoropropane-1,3-diyl)bis(phosphonate)
  参考文献：
  名称：

  Nucleophilic additions of [(diethoxyphosphoryl)difluoromethyl]lithium to α,β-unsaturated compounds

  摘要：

  The presence of HMPA leads to an increase of 1,4- versus 1,2-additions of [(diethoxyphosphoryl)difluoromethyl]lithium onto alpha,beta-unsaturated ketones and provides products of conjugated addition in moderate to good yields. In the absence of HMPA, benzylidine or alkylidine 1,3-diones, malononitriles or malonates as well as nitroalkenes and other Michael acceptors give products of 1,4-addition in good to high yields. (c) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2012.02.003

文献信息

• Hu, Chang-Ming; Chen, Jian, Journal of the Chemical Society. Perkin transactions I, 1993, # 3, p. 327 - 330
  作者：Hu, Chang-Ming、Chen, Jian

  DOI：——

  日期：——
• Hu Chang-Ming, Chen Jian, J. Chem. Soc. Perkin Trans. 1, (1993) N 3, S 327-330
  作者：Hu Chang-Ming, Chen Jian

  DOI：——

  日期：——
• Nucleophilic additions of [(diethoxyphosphoryl)difluoromethyl]lithium to α,β-unsaturated compounds
  作者：Prabhakar Cherkupally、Petr Beier

  DOI：10.1016/j.jfluchem.2012.02.003

  日期：2012.5

  The presence of HMPA leads to an increase of 1,4- versus 1,2-additions of [(diethoxyphosphoryl)difluoromethyl]lithium onto alpha,beta-unsaturated ketones and provides products of conjugated addition in moderate to good yields. In the absence of HMPA, benzylidine or alkylidine 1,3-diones, malononitriles or malonates as well as nitroalkenes and other Michael acceptors give products of 1,4-addition in good to high yields. (c) 2012 Elsevier B.V. All rights reserved.