2-amino-4,8-octadecadiene-1,3-diol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-amino-4,8-octadecadiene-1,3-diol
• 英文别名: (4E,8Z)-Sphingadienine-C18；(4E,8E)-2-aminooctadeca-4,8-diene-1,3-diol
• 化学式: C₁₈H₃₅NO₂
• 分子量: 297.481
• InChiKey: RTQVJTLVVBJRJG-RICRECKTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  21
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 2-amino-4,8-octadecadiene-1,3-diol 在 吡啶 作用下， 生成 Acetic acid (2E,6E)-1-(2-acetoxy-1-acetylamino-ethyl)-hexadeca-2,6-dienyl ester
  参考文献：
  名称：

  Subrahmanyam; Kulatheeswaran; Rao, C. Venkateswara, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996, vol. 35, # 6, p. 578 - 580

  摘要：

  DOI：
• 作为产物：
  描述：

  N-hexadecanoyl-1,3-dihydroxy-2-amino-4,8-octadecadiene 在 硫酸 作用下， 以 甲醇 、 水 为溶剂， 生成 棕榈酸甲酯 、 2-amino-4,8-octadecadiene-1,3-diol
  参考文献：
  名称：

  Subrahmanyam; Kulatheeswaran; Rao, C. Venkateswara, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996, vol. 35, # 6, p. 578 - 580

  摘要：

  DOI：

文献信息

• Extracts of Cranberry and Methods of Using Thereof
  申请人：Alberte Randall S.

  公开号：US20100028469A1

  公开（公告）日：2010-02-04

  The present disclosure relates in part to extracts of cranberry ( Vaccinium macrocarpon ) comprising an enriched amount of certain compounds having anti-infective activity, e.g. antibacterial and/or antifungal activity, e.g. activity against C. albicans . Another aspect of the disclosure relates to combined cranberry and cinnamon extracts. In certain embodiments, these combined extracts have been optimized to control urinary tract infections caused by E. coli, S. aureus and C. albicans . Certain embodiments of the extract are enriched in bioactive compounds that have been shown to inhibit C. albicans adhesion and/or biofilm formation and its growth in vitro. In another aspect of the disclosure, the extracts are enriched in bioactives derived from cranberry and cinnamon that have been shown to inhibit the attachment and the growth of common urinary tract pathogens like E. coli, S. aureus and C. albicans.
• USE OF UNSATURATED SPHINGOSINE COMPOUNDS AS CHEMOTHERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER
  申请人：Saba Julie D.

  公开号：US20110098317A1

  公开（公告）日：2011-04-28

  The present invention is directed to unsaturated sphingosine compounds which are useful as therapeutic agents for the treatment of cancer and for the treatment of other diseases including diabetes and infection with intracellular bacteria. This invention is also directed to methods of using the compounds and pharmaceutical compositions comprising the compounds in treating these diseases.
• US8741967B2
  申请人：——

  公开号：US8741967B2

  公开（公告）日：2014-06-03
• US9133097B2
  申请人：——

  公开号：US9133097B2

  公开（公告）日：2015-09-15
• [EN] USE OF UNSATURATED SPHINGOSINE COMPOUNDS AS CHEMOTHERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER<br/>[FR] UTILISATION DE COMPOSÉS DE SPHINGOSINE INSATURÉE EN TANT QU'AGENTS CHIMIOTHÉRAPEUTIQUES POUR LE TRAITEMENT DU CANCER
  申请人：CHILDRENS HOSP & RES CT OAK

  公开号：WO2009076598A1

  公开（公告）日：2009-06-18

  The present invention is directed to unsaturated sphingosine compounds which are useful as therapeutic agents for the treatment of cancer and for the treatment of other diseases including diabetes and infection with intracellular bacteria. This invention is also directed to methods of using the compounds and pharmaceutical compositions comprising the compounds in treating these diseases.