1-[2-(1-Benzyl-2,5-dimethylpyrrol-3-yl)-2-oxoethyl]-3-methylimidazolidine-2,4,5-trione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1-[2-(1-Benzyl-2,5-dimethylpyrrol-3-yl)-2-oxoethyl]-3-methylimidazolidine-2,4,5-trione
• 化学式: C₁₉H₁₉N₃O₄
• 分子量: 353.4
• InChiKey: FJCVBKSKQXCVJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  79.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• PHARMACEUTICAL COMPOSITION INCLUDING MIGRATORY FACTOR FOR GUIDING PLURIPOTENT STEM CELLS TO INJURY
  申请人：Clio, Inc.

  公开号：EP2962698A1

  公开（公告）日：2016-01-06

  The purpose of the present invention is to identify a migratory factor that guides pluripotent stem cells (Muse cells) useful in new medical applications to damage, and to provide a pharmaceutical composition that includes the migratory factor for promoting tissue regeneration in regenerative medicine that makes use of Muse cells. In the present invention, a receptor that is specifically expressed in Muse cells rather than non-Muse cells was identified, and it was confirmed that a ligand for this receptor can function as a migratory factor. In the present invention, sphingosine-1-phosphate (S1P) was identified as a migratory factor, and thus, the present invention pertains to a pharmaceutical composition for guiding pluripotent stem cells to damage, the composition including SIP as an active ingredient.

  本发明的目的是鉴定一种可引导多能干细胞（缪斯细胞）在新的医疗应用中发挥作用的迁移因子，并提供一种包含该迁移因子的药物组合物，用于促进再生医学中利用缪斯细胞的组织再生。在本发明中，确定了一种在缪斯细胞而非非缪斯细胞中特异表达的受体，并证实该受体的配体可作为迁移因子发挥作用。在本发明中，鞘氨醇-1-磷酸（S1P）被确定为一种迁移因子，因此，本发明涉及一种用于引导多能干细胞受损的药物组合物，该组合物包括作为活性成分的SIP。
• Pharmaceutical composition including migratory factor for guiding pluripotent stem cells to damage
  申请人：CLIO, INC.

  公开号：US10034889B2

  公开（公告）日：2018-07-31

  The purpose of the present invention is to identify a migratory factor that guides pluripotent stem cells (Muse cells) useful in new medical applications to damage, and to provide a pharmaceutical composition that includes the migratory factor for promoting tissue regeneration in regenerative medicine that makes use of Muse cells. In the present invention, a receptor that is specifically expressed in Muse cells rather than non-Muse cells was identified, and it was confirmed that a ligand for this receptor can function as a migratory factor. In the present invention, sphingosine-1-phosphate (S1P) was identified as a migratory factor, and thus, the present invention pertains to a pharmaceutical composition for guiding pluripotent stem cells to damage, the composition including S1P as an active ingredient.

  本发明的目的是鉴定一种可引导多能干细胞（缪斯细胞）在新的医疗应用中发挥作用的迁移因子，并提供一种包含该迁移因子的药物组合物，用于促进再生医学中利用缪斯细胞的组织再生。在本发明中，确定了一种在缪斯细胞而非非缪斯细胞中特异表达的受体，并证实该受体的配体可作为迁移因子发挥作用。在本发明中，鞘氨醇-1-磷酸（S1P）被确定为一种迁移因子，因此，本发明涉及一种引导多能干细胞受损的药物组合物，该组合物包括作为活性成分的S1P。
• PHARMACEUTICAL COMPOSITION INCLUDING MIGRATORY FACTOR FOR GUIDING PLURIPOTENT STEM CELLS TO DAMAGE
  申请人：CLIO INC.

  公开号：US20160354393A1

  公开（公告）日：2016-12-08

  The purpose of the present invention is to identify a migratory factor that guides pluripotent stem cells (Muse cells) useful in new medical applications to damage, and to provide a pharmaceutical composition that includes the migratory factor for promoting tissue regeneration in regenerative medicine that makes use of Muse cells. In the present invention, a receptor that is specifically expressed in Muse cells rather than non-Muse cells was identified, and it was confirmed that a ligand for this receptor can function as a migratory factor. In the present invention, sphingosine-1-phosphate (S1P) was identified as a migratory factor, and thus, the present invention pertains to a pharmaceutical composition for guiding pluripotent stem cells to damage, the composition including S1P as an active ingredient.
• US9446033B2
  申请人：——

  公开号：US9446033B2

  公开（公告）日：2016-09-20