N-methyl-N-[2-[bis(p-fluorophenyl)methoxy]ethyl]amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-methyl-N-[2-[bis(p-fluorophenyl)methoxy]ethyl]amine
• 英文别名: 2-[bis(4-fluorophenyl)methoxy]-N-methylethanamine
• 化学式: C₁₆H₁₇F₂NO
• 分子量: 277.314
• InChiKey: HBZDYHGQCUHADJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,4-苯并二氧六环-2-甲酸乙酯 、 N-methyl-N-[2-[bis(p-fluorophenyl)methoxy]ethyl]amine 在 potassium carbonate 、 N,N'-二环己基碳二亚胺 作用下， 以 甲苯 为溶剂， 反应 48.0h， 以58%的产率得到2,3-Dihydro-benzo[1,4]dioxine-2-carboxylic acid {2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-methyl-amide
  参考文献：
  名称：

  Design and synthesis of substituted compounds containing the 1,4-benzodioxin subunit. New potential calcium antagonists

  摘要：

  New compounds possessing 1,4-benzodioxin or its saturated analogous heterocyclic system were synthesized and tested for calcium antagonist activity. Biological differences were seen between the different modifications applied. These compounds have been shown to be representative of a novel series of calcium channel antagonists. (C) 2000 editions scientifiques et medicates Elsevier SAS.

  DOI：

  10.1016/s0223-5234(00)00164-1

文献信息

• Preparation of N-arylpiperazines and other N-aryl compounds from aryl bromides as scaffolds of bioactive compounds
  作者：M. Romero、Y. Harrak、J. Basset、L. Ginet、P. Constans、M.D. Pujol

  DOI：10.1016/j.tet.2006.07.011

  日期：2006.9

  Aryl bromides are coupled with N-compounds to give the corresponding arylamines in the presence of a palladium catalyst, a suitable ligand, and a weak base. The catalysts perform well for a large number of different starting material combinations at 100–150 °C with drops of toluene or without solvent, and with low catalyst levels (0.12 mol % Pd). The low catalyst amount makes the process environment

  在钯催化剂，合适的配体和弱碱的存在下，使芳基溴化物与N-化合物偶合，得到相应的芳基胺。在100–150°C的温度下，使用甲苯滴或不添加溶剂，并且催化剂含量低（Pd为0.12 mol％）时，该催化剂在大量不同的起始原料组合中表现良好。低催化剂量使工艺环境友好。
• Synthesis of Dioxigenated Systems. Preparation of Homologues of 1,4-Benzodioxin as Calcium Antagonists
  作者：I. Sánchez、M. Pujol、G. Guillaument、R. Massingham、A. Monteil

  DOI：10.3797/scipharm.aut-01-02

  日期：——

  A new compound (9), homologue of 1,4-benzodioxin, has been prepared and tested as calcium antagonist. Additionally, the intermediates 12 and 13 with structure of aminodiol, were also evaluated as anticalcium agents. All of them showed a moderate anticalcium activity.

  一种新的化合物（9），与1,4-苯并二氧杂环同系物，已经制备并作为钙拮抗剂进行了测试。此外，具有氨基二醇结构的中间体12和13也被评估为抗钙剂。它们都显示出适度的抗钙活性。
• Design and synthesis of substituted compounds containing the 1,4-benzodioxin subunit. New potential calcium antagonists
  作者：Isabel Sánchez、Maria Dolors Pujol、Gerald Guillaumet、Roy Massingham、André Monteil、Georges Dureng、Eileen Winslow

  DOI：10.1016/s0223-5234(00)00164-1

  日期：2000.8

  New compounds possessing 1,4-benzodioxin or its saturated analogous heterocyclic system were synthesized and tested for calcium antagonist activity. Biological differences were seen between the different modifications applied. These compounds have been shown to be representative of a novel series of calcium channel antagonists. (C) 2000 editions scientifiques et medicates Elsevier SAS.