噻唑并[5,4-b]吡啶-2(1H)-酮 | 90180-85-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 噻唑并[5,4-b]吡啶-2(1H)-酮
• 英文名称: Thiazolo[5,4-b]pyridin-2(1H)-one
• 英文别名: 1H-[1,3]thiazolo[5,4-b]pyridin-2-one
• CAS: 90180-85-1
• 化学式: C₆H₄N₂OS
• 分子量: 152.18
• InChiKey: HXNDHWLIFLZUKR-UHFFFAOYSA-N

物化性质

• 密度：
  1.466±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  67.3
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  benzyl 3-chloropropanoate 、 噻唑并[5,4-b]吡啶-2(1H)-酮 生成 Benzyl 3-(2-oxo-[1,3]thiazolo[5,4-b]pyridin-1-yl)propanoate
  参考文献：
  名称：

  TSUDA, JOSIXIKO;TSUDA, JOSIAKI

  摘要：

  DOI：

文献信息

• COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY
  申请人：Li Hui

  公开号：US20120028923A1

  公开（公告）日：2012-02-02

  Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful. Also disclosed are methods of making the compounds.

  披露了公式I的化合物，含有它们的组合物，以及使用这些化合物和组合物治疗调节JAK途径或抑制JAK激酶，特别是JAK2和JAK3，具有治疗用途的条件的方法。还披露了制造这些化合物的方法。
• Pyridyl alkane acid amides as cytostatics and immunosupressives
  申请人：Klinge Pharma GmbH

  公开号：US20030162972A1

  公开（公告）日：2003-08-28

  The invention relates to new pyridyl alkane acid amides according to general formula (I) as well as methods for their production, medicaments containing these compounds as well as their medical use, especially in the treatment of tumors or for immunosuppression. 1

  该发明涉及按照通式（I）的新吡啶基烷基酸酰胺，以及其生产方法，含有这些化合物的药物以及它们在医学上的应用，特别是在肿瘤治疗或免疫抑制方面的用途。
• Thienopyrimidinediones and their use in the modulation of autoimmune disease
  申请人：——

  公开号：US20040254198A1

  公开（公告）日：2004-12-16

  The invention relates to a compound of formula (1); wherein: R 1 and R 2 each independently represent a C 1-6 alkyl, C 3-6 alkenyl, C 3-6 cycloalkyl C 1-3 alkyl or C 3-6 cycloalkyl; each of which may be optionally substituted by 1 to 3 halogen atoms; R 3 is isoxyzolidin-2-ylcarbonyl or tetrahydroisoxazin-2-ylcarbonyl wherein each ring is optionally substituted by one hydroxy group; Q is CO— or C(R 4 )(R 5 )—(wherein R 4 is a hydrogen atom or C 1-4 alkyl and R 5 is a hydrogen atom or hydroxy group); Ar is a 5- to 10-membered aromatic ring system wherein up to 4 ring atoms may be heteroatoms independently selected from nitrogen, oxygen and sulphur, the ring system being optionally substituted by one or more substituents as defined in the specification. It also relates to methods of preparing, pharmaceutical compositions containing and methods of using the compound of the formula (1), particularly in the modulation of autoimmune disease. 1

  本发明涉及一种式子(1)的化合物; 其中：R1和R2各自独立地表示C1-6烷基，C3-6烯基，C3-6环烷基，C1-3烷基或C3-6环烷基; 每个基团可能被1至3个卤素原子取代; R3是异噁唑啉-2-基甲酰基或四氢异噁唑啉-2-基甲酰基，其中每个环可能被一个羟基取代; Q是CO-或C（R4）（R5）-（其中R4是氢原子或C1-4烷基，R5是氢原子或羟基）; Ar是一个5-至10-成员的芳香环系统，其中最多4个环原子可以独立地选自氮，氧和硫，该环系统可能被一个或多个定义在说明书中的取代基取代。它还涉及制备，含有该式（1）化合物的制药组合物以及使用该化合物的方法，特别是在自身免疫性疾病的调节中使用。
• Pyridyl alkene- and pyridyl alkine- acid amides as cytostatics and immuno-suppressives
  申请人：Klinge Pharma GmbH

  公开号：US20040009967A1

  公开（公告）日：2004-01-15

  The invention relates to new pyridyl alkane acid amides according to general formula (I) as well as methods for their production, medicaments containing these compounds as well as their medical use, especially in the treatment of tumors or for immunosuppression.

  本发明涉及新的吡啶基烷基酸酰胺，其通式为（I），以及其制备方法，含有这些化合物的药物以及它们在医学上的使用，特别是用于肿瘤治疗或免疫抑制。
• Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
  申请人：Klinge Pharma GmbH

  公开号：US20040029861A1

  公开（公告）日：2004-02-12

  The invention relates to the use of pharmacologically valuable pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides according to general formula (I) in the treatment of tumors or for immunosuppression. 1

  该发明涉及在肿瘤治疗或免疫抑制中使用具有药理学价值的吡啶基烷基、吡啶基烯烃和/或吡啶基炔烃酸酰胺，其通用式为（I）。1