四(十八烷基)溴化铵 | 63462-99-7

• 物质功能分类: 分析化学 - 分析试剂 - 常用分析试剂
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 四(十八烷基)溴化铵
• 英文名称: Tetraoctadecylammonium bromide
• 英文别名: tetraoctadecylazanium;bromide
• CAS: 63462-99-7
• 化学式: C72H148BrN
• 分子量: 1107.9
• InChiKey: BUXYZRAZWWVKDS-UHFFFAOYSA-M

物化性质

• 熔点：
  103-105 °C (lit.)
• 碰撞截面：
  372.9 Ų [M*]+
• 稳定性/保质期：

  远离氧化物和酸。

计算性质

• 辛醇/水分配系数(LogP)：
  23.85
• 重原子数：
  74
• 可旋转键数：
  68
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38
• WGK Germany：
  3
• 海关编码：
  2923900090

文献信息

• ALTERNATIVE PHTHALOCYANINE DYES SUITABLE FOR USE IN OFFSET INKS
  申请人：Starling Scott Matthew

  公开号：US20090035533A1

  公开（公告）日：2009-02-05

  A phthalocyanine salt suitable for formulation in a solvent-based or oil-based ink vehicle is disclosed. The phthalocyanine comprises one or more sulfonate groups and a counterion of at least one sulfonate group is an ammonium cation comprising at least 15 carbon atoms. Ammonium salts of sulfonated gallium naphthalocyanines exemplify such phthalocyanine salts.

  本发明公开了适合在溶剂基或油基油墨载体中制剂的酞菁盐。该酞菁包括一个或多个磺酸基团，至少一个磺酸基团的对离子是含有至少15个碳原子的铵阳离子。磺化镓萘酞菁的铵盐是这种酞菁盐的示例。
• Process for preparation of allyl sulfone derivatives and intermediates for the preparation
  申请人：——

  公开号：US20040054233A1

  公开（公告）日：2004-03-18

  The present invention relates to a process for producing an allyl sulfone derivative represented by the formula (3): 1 wherein Ar is an optionally substituted aryl group, and the corrugated line means either one of E/Z geometrical isomers, or a mixture thereof, which is an intermediate for producing vitamin A, which process is characterized by reacting an aryl sulfinic acid or a salt thereof represented by the formula (2): ArSO 2 M (2) wherein Ar is as defined above, and M is hydrogen atom, sodium atom or potassium atom, with an allyl halide derivative represented by the formula (1): 2 wherein X is a halogen atom, and Ar and the corrugated line are as defined above.

  本发明涉及一种制备烯丙基磺酰衍生物的方法，该衍生物由公式（3）表示：其中Ar是一种可选取的取代芳基，而波浪线表示E/Z几何异构体之一或其混合物，是生产维生素A的中间体。该方法的特点在于，将由公式（2）表示的芳基亚磺酸或其盐（其中Ar如上定义，M为氢原子、钠原子或钾原子）与由公式（1）表示的烯丙基卤化衍生物反应（其中X为卤素原子，Ar和波浪线如上定义）。
• TROMETHAMINE SALT OF BIMATOPROST ACID IN CRYSTALLINE FORM 1, METHODS FOR PREPARATION, AND METHODS FOR USE THEREOF
  申请人：ALLERGAN, INC.

  公开号：US20150376125A1

  公开（公告）日：2015-12-31

  The present invention provides tromethamine salt of (Z)-7-[3,5-Dihydroxy-2-((E)-3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid in crystalline Form 1 and amorphous form. This compound is may also be referred to as “tromethamine salt of bimatoprost acid.” The invention crystalline form is useful for solid ocular implant or topical formulations, utilized in the treatment of various ocular conditions, such as, for example, ocular hypertension.

  本发明提供了晶体形式1和非晶态形式的（Z）-7- [3,5-二羟基-2-（（E）-3-羟基-5-苯基-戊-1-烯基）-环戊基] -庚-5-烯酸的曲美他明盐。该化合物也可以称为“贝马托普罗斯酸的曲美他明盐”。本发明的晶体形式适用于固体眼内植入物或局部制剂，用于治疗各种眼部疾病，例如眼压增高。
• [EN] TROMETHAMINE SALT OF BIMATOPROST ACID IN CRYSTALLINE FORM 1, METHODS FOR PREPARATION, AND METHODS FOR USE THEREOF<br/>[FR] SEL DE TROMÉTHAMINE DE BIMATOPROST ACIDE SOUS LA FORME CRISTALLINE 1, PROCÉDÉS DE PRÉPARATION ET PROCÉDÉS D'UTILISATION ASSOCIÉS
  申请人：ALLERGAN INC

  公开号：WO2015199729A1

  公开（公告）日：2015-12-30

  The present invention provides tromethamine salt of (Z)-7-[3,5-Dihydroxy-2-((E)-3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid in crystalline Form 1 and amorphous form. This compound is may also be referred to as "tromethamine salt of bimatoprost acid." The invention crystalline form is useful for solid ocular implant or topical formulations, utilized in the treatment of various ocular conditions, such as, for example, ocular hypertension.

  本发明提供了晶体形式1和非晶态形式的(Z)-7-[3,5-二羟基-2-((E)-3-羟基-5-苯基-戊-1-烯基)-环戊基]-庚-5-烯酸的醇胺盐。该化合物也可以称为“贝马特普罗斯特酸的醇胺盐”。本发明的晶体形式可用于固体眼内植入物或局部制剂，用于治疗各种眼部疾病，例如眼压增高。
• PROCESS FOR PRODUCING PHOSPHINE OXIDE VITAMIN D PRECURSORS
  申请人：Saha Uttam

  公开号：US20080300427A1

  公开（公告）日：2008-12-04

  A process for producing a compound of the formula: including reacting of a compound of the formula: with diphenyl phosphine oxide using a binary phase reaction mixture including diphenyl phosphine oxide in an organic solvent, a basic aqueous solution, and a phase transfer catalyst, to obtain the compound of formula 1, wherein Ph is phenyl, X 1 and X 2 are both hydrogen or X 1 and X 2 taken together are CH 2 , R 1 is a protecting group, R 2 is fluorine, hydrogen, or OR 3 , wherein R 3 is a protecting group, and the squiggly line represents a bond that results in the adjacent double bond being in either the E or Z configuration, is disclosed.

  本发明涉及一种制备式化合物的方法，包括使用二元相反应混合物，包括二苯基膦氧化物在有机溶剂、碱性水溶液和相转移催化剂的情况下，与式化合物反应：以获得式1的化合物，其中Ph表示苯基，X1和X2均为氢或X1和X2共同为CH2，R1为保护基，R2为氟、氢或OR3，其中R3为保护基，而波浪线表示相邻双键处在E或Z构型的键。