四丁基铵亚硫酸酯 | 87742-13-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 四丁基铵亚硫酸酯
• 中文别名: 8-氯-6-苯基[1,2,4]三唑并[3,4-a]酞嗪
• 英文名称: tetrabutylammonium hydrogen sulfite
• 英文别名: tetrabutylammonium bisulphite；(n-Bu4N)HSO3；tetrabutylammonium hydrogen sulfate；NBu4(+)*HSO3(-)；tetrabutyl ammonium bisulfite；(n-Bu)4NHSO4；Bu4NHSO3；TBAHSO4；Hydron;tetrabutylazanium;sulfite
• CAS: 87742-13-0
• 化学式: C₁₆H₃₆N*HO₃S
• 分子量: 323.541
• InChiKey: RKUPXQGCEBDURP-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  4.34
• 重原子数：
  21
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  79.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  21,43-Ditert-butyl-10,10,32,32-tetramethyl-2,3,4,16,17,18,24,25,26,38,39,40,47,48,52,53-hexadecazaundecacyclo[39.3.1.12,5.16,9.111,14.115,18.119,23.124,27.128,31.133,36.137,40]tetrapentaconta-1(45),3,5(54),6,8,11,13,15(51),16,19(50),20,22,25,27(49),28,30,33,35,37(46),38,41,43-docosaene 、 四丁基铵亚硫酸酯 以 氯仿 为溶剂， 生成
  参考文献：
  名称：

  A Pyrrolyl-Based Triazolophane: A Macrocyclic Receptor With CH and NH Donor Groups That Exhibits a Preference for Pyrophosphate Anions

  摘要：

  A pyrrolyl-based triazolophane, incorporating CH and NH donor groups, acts as a receptor for the pyrophosphate anion in chloroform solution. It shows selectivity for this trianion, followed by HSO4- > H2PO4- > Cl- > Br- (all as the corresponding tetrabutylammonium salts), with NH-anion interactions being more important than CH-anion interactions. In the solid state, the receptor binds the pyrophosphate anion in a clip-like slot via NH and CH hydrogen bonds.

  DOI：

  10.1021/ja107098r
• 作为试剂：
  描述：

  三苯甲硫醇 、 alkaline earth salt of/the/ methylsulfuric acid 在 氢氧化钾 、 sodium hydroxide 、 potassium carbonate 、 四丁基铵亚硫酸酯 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 水 为溶剂， 反应 12.5h， 生成 N-(3-triphenylmethylthiopropyl)benzanilide
  参考文献：
  名称：

  光学活性1,12-二甲基苯并[ c ]菲-5,8-二酰胺的合成，单层行为及手性朗缪尔-布洛杰特膜的形成

  摘要：

  我们以前曾报道过，由螺旋手性1,12-二甲基苯并[ c ]菲-5，8-二羧酸组成的旋光环状酰胺在水表面形成稳定的单层，并且该单层可以转移到固体载体上得到光学活性的朗缪尔-布洛杰特（LB）膜。在这项研究中，合成了几种相关的酰胺，并对其单层行为进行了研究，以期制备具有官能团的光学活性LB膜。结果表明，环状酰胺结构和环己基部分对于在水表面形成稳定的单分子层至关重要。仲酰胺的N-烷基化不会严重影响单层的形成，而手性LB膜可通过N，N获得环酰胺的-双（3-巯基丙基）衍生物。

  DOI：

  10.1016/s0040-4020(99)00969-2

文献信息

• Process for the preparation of di- and poly-allyl ethers
  申请人：Ciba-Geigy Corporation

  公开号：US04433179A1

  公开（公告）日：1984-02-21

  A process for the preparation of allyl ethers of the formula R--O--CH.sub.2 --CH.dbd.CH.sub.2).sub.n in which R and n are as defined in claim 1, by reacting hydroxy compounds of the formula R--OH).sub.n with allyl chloride or allyl bromide by phase transfer catalysis, 0.8 to 5 mols of allyl chloride or allyl bromide, 1 to 6 mols of aqueous or solid sodium hydroxide and, as the phase transfer catalyst, 2 to 20 mol % of a quaternary ammonium salt, a quaternary ammonium base or a crown ether being employed per hydroxyl equivalent of the compound of the formula II, and the reaction being carried out in the temperature range from 20.degree. to 100.degree. C.

  一种制备化学式为R--O--CH.sub.2 --CH.dbd.CH.sub.2).sub.n的烯丙基醚的方法，其中R和n如权利要求1所定义，通过相转移催化，将化学式为R--OH).sub.n的羟基化合物与烯丙基氯或烯丙基溴反应，使用0.8至5摩尔的烯丙基氯或烯丙基溴，1至6摩尔的水合或固体氢氧化钠，作为相转移催化剂，每个化合物II的羟基当量使用2至20摩尔%的季铵盐、季铵碱或冠醚，并在20°C至100°C的温度范围内进行反应。
• Enantioselective Intermolecular C–H Amination Directed by a Chiral Cation
  作者：Alexander Fanourakis、Benjamin D. Williams、Kieran J. Paterson、Robert J. Phipps

  DOI：10.1021/jacs.1c05206

  日期：2021.7.14

  The enantioselective amination of C(sp3)–H bonds is a powerful synthetic transformation yet highly challenging to achieve in an intermolecular sense. We have developed a family of anionic variants of the best-in-class catalyst for Rh-catalyzed C–H amination, Rh2(esp)2, with which we have associated chiral cations derived from quaternized cinchona alkaloids. These ion-paired catalysts enable high levels

  C( sp 3 )-H 键的对映选择性胺化是一种强大的合成转化，但在分子间意义上实现却极具挑战性。我们开发了一系列用于 Rh 催化的 C–H 胺化的一流催化剂的阴离子变体，Rh 2 (esp) 2，我们将衍生自季铵化金鸡纳生物碱的手性阳离子与它们相关联。这些离子对催化剂能够在带有侧羟基的底物的苄基 C-H 胺化中实现高水平的对映选择性。此外，手性阳离子的喹啉似乎与铑络合物进行轴向连接，与 Rh 2 (esp) 2相比，提供了更高的产物产率并突出阳离子所发挥的双重作用。这些结果强调了使用手性阳离子在具有挑战性的过渡金属催化转化中控制对映选择性的潜力。
• Novel [F-18]-labelled L-glutamic acid and L-glutamine derivatives (II), their use and processes for their preparation
  申请人：Dinkelborg Ludger

  公开号：US20110104057A1

  公开（公告）日：2011-05-05

  What is described are the compounds and the synthesis of [F-18]-labelled L-glutamic acid, [F-18]-labelled L-glutamate, their derivatives of the formula (I) and their use.

  描述的是化合物和[F-18]-标记的L-谷氨酸、[F-18]-标记的L-谷氨酸盐以及它们的衍生物的合成，以及它们的应用。
• [EN] METHOD OF PRODUCING AMINOPHENOL COMPOUNDS<br/>[FR] PROCEDE DE FABRICATION DE COMPOSES AMINOPHENOLS
  申请人：OTSUKA PHARMA CO LTD

  公开号：WO2005092832A1

  公开（公告）日：2005-10-06

  The present invention provides an industrially advantageous method of producing aminophenol compounds represented by the formula (1) by a simple and easy procedure at a high yield and a high purity. The present invention provides a method of producing an aminophenol compound represented by the formula (1): (wherein each of R1 and R2, which may be the same or different, is a hydrogen atom, a substituted or unsubstituted lower alkyl group or the like; R1 and R2, taken together with the adjacent nitrogen atom, may form a 5- or 6-membered heterocycle with or without other intervening heteroatoms; the heterocycle may be substituted by 1 to 3 substituents selected from the group consisting of a hydroxyl group, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aryloxy group and the like; and the hydroxyl group in the formula (1) is substituted on the 2- or 4-position to the amino group on the phenyl ring), which comprises allowing a cyclohexanedione compound represented by the formula (2) to react with an amine compound represented by the formula (3) (wherein R1 and R2 are as defined above), under a neutral or basic condition.

  本发明提供一种在高产率和高纯度下通过简单易行的程序生产由式（1）表示的氨基酚化合物的工业上有利的方法。本发明提供了一种生产由式（1）表示的氨基酚化合物的方法：（其中R1和R2中的每一个，可能相同也可能不同，是氢原子，取代或未取代的较低烷基基团或类似物；R1和R2与相邻氮原子一起可以形成5或6成员的杂环，有或无其他插入的杂原子；该杂环可以被1至3个取代基取代，所述取代基选自羟基团、取代或未取代的较低烷基基团、取代或未取代的芳基基团、取代或未取代的芳氧基团等；并且在式（1）中的羟基团被取代在苯环上的氨基团的2-或4-位置），其包括使由式（2）表示的环己二酮化合物与由式（3）表示的胺化合物（其中R1和R2如上定义）在中性或碱性条件下反应。
• PROCESS FOR PRODUCING BENZO[B][1,4]DIAZEPINE-2,4-DIONE COMPOUND
  申请人：Tsujimori Hisayuki

  公开号：US20120149899A1

  公开（公告）日：2012-06-14

  The present invention provides an industrially advantageous, simple, and efficient process for producing a key intermediate of a benzo[b][1,4]diazepine-2,4-dione compound, which is a therapeutic medicine for arrhythmia. The present invention relates to a process for producing a compound represented by formula (1), wherein each of R 1 , R 2 , R 3 and R 4 , which may be the same or different, represents a hydrogen atom or a lower alkyl group, the process including deprotecting a protective group (R 5 ) of a compound represented by formula (2), wherein R 1 , R 2 , R 3 and R 4 are as defined above, and R 5 represents a protective group of a hydroxy group.

  本发明提供了一种在工业上具有优势的、简单而高效的生产苯并[b][1,4]二氮杂环己二酮化合物的关键中间体的方法，该化合物是心律失常的治疗药物。本发明涉及一种生产由式（1）表示的化合物的方法，其中R1、R2、R3和R4中的每一个，可以相同也可以不同，表示氢原子或低碳基团，该方法包括去保护式（R5）的步骤，该保护式是由式（2）表示的化合物的保护基，其中R1、R2、R3和R4如上定义，R5表示羟基的保护基。