3-epi-plakoridine B

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-epi-plakoridine B
• 英文别名: methyl (2S,3S,4S,5E)-4-hydroxy-1-[2-(4-hydroxyphenyl)ethyl]-5-(2-oxooctadecylidene)-2-pentadecylpyrrolidine-3-carboxylate
• 化学式: C₄₇H₈₁NO₅
• 分子量: 740.164
• InChiKey: TWRZIDCNMWOSFX-LKLXJYAJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  16.9
• 重原子数：
  53
• 可旋转键数：
  35
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  87.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  十六醛 在 magnesium sulfate 作用下， 以 氘代氯仿 为溶剂， 反应 264.0h， 生成 3-epi-plakoridine B
  参考文献：
  名称：

  Chemical predisposition in synthesis: application to the preparation of the pyrrolidine natural products, plakoridines A and B

  摘要：

  The pyrrolidine natural products, plakoridines A and B, as well as an array of unnatural analogues, have been prepared using a five-step synthetic sequence modelled on a biogenetic theory. The key transformation involves a `Mannich/Michael/intemal-redox' cascade, which proceeds in yields of 31-63%. (c) 2006 Elsevier Ltd. All fights reserved.

  DOI：

  10.1016/j.tet.2006.08.075

文献信息

• Chemical predisposition in synthesis: application to the preparation of the pyrrolidine natural products, plakoridines A and B
  作者：Laura L. Etchells、Madeleine Helliwell、Neil M. Kershaw、Ali Sardarian、Roger C. Whitehead

  DOI：10.1016/j.tet.2006.08.075

  日期：2006.11

  The pyrrolidine natural products, plakoridines A and B, as well as an array of unnatural analogues, have been prepared using a five-step synthetic sequence modelled on a biogenetic theory. The key transformation involves a `Mannich/Michael/intemal-redox' cascade, which proceeds in yields of 31-63%. (c) 2006 Elsevier Ltd. All fights reserved.