3-(2-(hydroxymethyl)-4-methoxyphenyl)-6-methoxyquinazoline-2,4(1H,3H)-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-(2-(hydroxymethyl)-4-methoxyphenyl)-6-methoxyquinazoline-2,4(1H,3H)-dione
• 英文别名: 3-[2-(hydroxymethyl)-4-methoxyphenyl]-6-methoxy-1H-quinazoline-2,4-dione
• 化学式: C₁₇H₁₆N₂O₅
• 分子量: 328.324
• InChiKey: JRIRAYLCMMHKLC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  88.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-甲氧基-2-硝基苯甲酸 在 六甲基磷酰三胺 、 lithium aluminium tetrahydride 、 硫酸 、 palladium 10% on activated carbon 、 氢气 作用下， 以 四氢呋喃 、 甲醇 、 乙腈 为溶剂， 反应 127.0h， 生成 3-(2-(hydroxymethyl)-4-methoxyphenyl)-6-methoxyquinazoline-2,4(1H,3H)-dione
  参考文献：
  名称：

  Concise Synthesis of Dictyoquinazol A via a Dimerisation–Cyclocondensation Sequence

  摘要：

  A two-step total synthesis of the neuroprotective alkaloid, dictyoquinazol A, has been achieved. The brevity of this synthesis was enabled by exploiting the hidden symmetry of the target molecule. Several structural analogues were also prepared using a similar strategy. These results provide a platform for future structure-activity relationship studies in the quest for a novel treatment for stroke.

  DOI：

  10.1055/s-0035-1561569

文献信息

• Concise Synthesis of Dictyoquinazol A via a Dimerisation–Cyclocondensation Sequence
  作者：Luke Hunter、Jonatan Wangsahardja、Gabriella Marcolin、Yuvixza Lizarme、Jonathan Morris

  DOI：10.1055/s-0035-1561569

  日期：——

  A two-step total synthesis of the neuroprotective alkaloid, dictyoquinazol A, has been achieved. The brevity of this synthesis was enabled by exploiting the hidden symmetry of the target molecule. Several structural analogues were also prepared using a similar strategy. These results provide a platform for future structure-activity relationship studies in the quest for a novel treatment for stroke.