2,3-dihydro-2,2,5,7-tetramethylbenzofuran

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 香豆素
• 英文名称: 2,3-dihydro-2,2,5,7-tetramethylbenzofuran
• 英文别名: 2,2,5,7-tetramethyl-3H-1-benzofuran
• 化学式: C₁₂H₁₆O
• 分子量: 176.258
• InChiKey: IEQPEVSKJNYYHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-(3,5-dimethyl-phenyl)-2-methyl-propan-2-ol 在 碘苯二乙酸 、 palladium diacetate 、 lithium carbonate 作用下， 以 六氟苯 为溶剂， 反应 36.0h， 生成 2,3-dihydro-2,2,5,7-tetramethylbenzofuran
  参考文献：
  名称：

  Pd(II)-Catalyzed Hydroxyl-Directed C−H Activation/C−O Cyclization: Expedient Construction of Dihydrobenzofurans

  摘要：

  A Pd(II)-catalyzed C-H activation/C-O cyclization reaction directed by a proximate hydroxyl group has been developed. This reaction provides a new method for constructing dihydrobenzofurans, including spirocyclic analogues, a process that is potentially applicable to natural product synthesis.

  DOI：

  10.1021/ja105366u

文献信息

• Mo(CO)6 Catalyzed One-Pot Conversion of Allyl Aryl Ethers to Dihydrobenzofurans
  作者：Angela M. Bernard、Maria T. Cocco、Valentina Onnis、Pier P. Piras

  DOI：10.1055/s-1997-1511

  日期：1997.1

  Molybdenum hexacarbonyl effectively catalyses a tandem Claisen rearrangement-cyclization reaction of allyl aryl ethers to give good yields of dihydrobenzofurans.

  六羰基钼有效催化了烯丙基芳醚的串联克莱森重排-环化反应，以良好的产率生成二氢苯并呋喃。
• SUBSTITUTED SPIROPIPERIDINYL COMPOUNDS USEFUL AS GPR120 AGONISTS
  申请人：CHELLIAH Mariappan

  公开号：US20150274672A1

  公开（公告）日：2015-10-01

  The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.

  本发明涉及一种由公式(I)表示的化合物及其药学上可接受的盐，用于治疗或预防糖尿病、高脂血症、肥胖症、与炎症相关的疾病和相关疾病和状况。该化合物是G蛋白偶联受体GPR120的激动剂，是有用的。还包括药物组成物和治疗方法。
• Optical Film, Manufacturing Method Thereof, Polarizing Plate Employing it and Liquid Crystal Display Device
  申请人：Suzuki Takatugu

  公开号：US20100003426A1

  公开（公告）日：2010-01-07

  Disclosed is an optical film having good haze properties, wherein bleedout hardly occurs and deformation problems of the raw material film such as horseback defects and projection defects do not occur even when the film is stored for a long time. Also disclosed are a method for producing such an optical film, a polarizing plate using the optical film, and a liquid crystal display using the polarizing plate. Specifically disclosed is an optical film characterized by containing at least one polymer compound derived from a compound represented by the following general formula (1). [chemical formula 1] (1) (In the formula, R 1 -R 6 independently represent a hydrogen atom or a substituent, and R 1 and R 2 may combine together to form a substituent bound by a double bond. In this connection, at least one of R 1 -R 6 represents a group having a polymerizable group as a partial structure.)