diphenyl 2-[2-tert-butylamino-1-methoxy-2-oxoethyl]malonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: diphenyl 2-[2-tert-butylamino-1-methoxy-2-oxoethyl]malonate
• 英文别名: Diphenyl 2-[2-t-butylamino-1-methoxy-2-oxo-ethyl]malonate；diphenyl 2-[2-(tert-butylamino)-1-methoxy-2-oxoethyl]propanedioate
• 化学式: C₂₂H₂₅NO₆
• 分子量: 399.444
• InChiKey: QFEMZBBPCTUCMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  29
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  90.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  5-(甲氧基甲烯基)-2,2-二甲基-1,3-二氧己环-4,6-二酮 、 异氰酸叔丁酯 、 苯酚 以 二氯甲烷 为溶剂， 以74%的产率得到diphenyl 2-[2-tert-butylamino-1-methoxy-2-oxoethyl]malonate
  参考文献：
  名称：

  An Efficient One-Pot Synthesis of Triamides and Amidodiesters

  摘要：

  An efficient one-pot procedure has been proposed for the synthesis of compounds containing three carboxamide groups or one carboxamide and two ester groups. The procedure is based on three-component condensation of alkyl isocyanides with 5-alkylidene- or 5-arylmethylene-substituted Meldrum's acids in the presence of such nucleophiles as phenols and amines.

  DOI：

  10.1023/b:rujo.0000045188.81414.1d

文献信息

• An Efficient One-Pot Synthesis of Triamides and Amidodiesters
  作者：A. Shaabani、M. B. Teimouri、H. R. Bijanzadeh

  DOI：10.1023/b:rujo.0000045188.81414.1d

  日期：2004.7

  An efficient one-pot procedure has been proposed for the synthesis of compounds containing three carboxamide groups or one carboxamide and two ester groups. The procedure is based on three-component condensation of alkyl isocyanides with 5-alkylidene- or 5-arylmethylene-substituted Meldrum's acids in the presence of such nucleophiles as phenols and amines.