2-(2,6-diethylphenyl)-5-hydroxyisoindoline-1,3-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-(2,6-diethylphenyl)-5-hydroxyisoindoline-1,3-dione
• 英文别名: 2-(2,6-diethylphenyl)-5-hydroxyisoindole-1,3-dione
• 化学式: C₁₈H₁₇NO₃
• 分子量: 295.338
• InChiKey: DEYSQEWYOOUGRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-羟基苯酐 生成 2-(2,6-diethylphenyl)-5-hydroxyisoindoline-1,3-dione
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Methods for treating autoimmune disorders, and reagents related thereto
  申请人：Bachovchin W. William

  公开号：US20050070459A1

  公开（公告）日：2005-03-31

  The invention generally relates to improved methods for treatment or prophylaxis in animal subjects (including humans) of autoimmune disorders including Type I diabetes, septic shock, multiple sclerosis, inflammatory bowel disease (IBD) and Crohn's disease.

  这项发明通常涉及改进的方法，用于治疗或预防动物主体（包括人类）的自身免疫性疾病，包括I型糖尿病、感染性休克、多发性硬化、炎症性肠病（IBD）和克罗恩病。
• Estrogen Receptor α/β Ligands Derived from Thalidomide
  作者：Tomomi Noguchi-Yachide、Kazuyuki Sugita、Yuichi Hashimoto

  DOI：10.3987/com-11-12287

  日期：——

  We have developed a series of thalidomide-derived phthalimide-type estrogen receptor (ER) modulators with characteristic subtype (ER alpha/ER beta) selectivity, and investigated their structure-activity relationship for ER agonistic and antagonistic activities.
• Inhibitors of NF-κB derived from thalidomide
  作者：Esperanza J. Carcache de-Blanco、Bulbul Pandit、Zhigen Hu、Jiandong Shi、Andrew Lewis、Pui-Kai Li

  DOI：10.1016/j.bmcl.2007.01.088

  日期：2007.11

  A series of compounds originally derived from thalidomide were synthesized and evaluated. The most potent compounds in this series, 5HPP-33 and compound 20, inhibited NF-kappaB activation in HeLa cells. Preliminary study indicated that the mechanism of inhibition of NF-kappaB activation is through inhibition of its translocation from the cytoplasm to the nucleus.
• ——
  作者：AOKI ATSUSI、 EHNDO TOSIMITSU、 NAKANISI ITSURO、 KAMIDA TAKAYUKI

  DOI：——

  日期：——
• METHODS FOR TREATING AUTOIMMUNE DISORDERS AND REAGENTS RELATED THERETO
  申请人：Trustees of Tufts College

  公开号：EP1487471A2

  公开（公告）日：2004-12-22