4,6,7-trimethyl-3-phenyl-3H-spiro[1-benzofuran-2,1'-cyclopropane]

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 香豆素
• 英文名称: 4,6,7-trimethyl-3-phenyl-3H-spiro[1-benzofuran-2,1'-cyclopropane]
• 英文别名: 2-(3-phenyl-4,6,7-trimethyl-2,3-dihydro-1-benzofuran)-spiro-1'-cyclopropane；4,6,7-trimethyl-3-phenylspiro[3H-1-benzofuran-2,1'-cyclopropane]
• 化学式: C₁₉H₂₀O
• 分子量: 264.367
• InChiKey: KPBDVPPCSRFIJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-苯基环丙基甲腈 在 三氟甲磺酸 、 二异丁基氢化铝 作用下， 以 甲苯 为溶剂， 反应 2.0h， 生成 4,6,7-trimethyl-3-phenyl-3H-spiro[1-benzofuran-2,1'-cyclopropane]
  参考文献：
  名称：

  A convenient ring formation of 3-aryl-2,2-dialkyl-2,3-dihydrobenzofurans from phenols and 2-aryl-2,2-dialkylacetaldehydes

  摘要：

  A new and simple route for the preparation of 3-aryl-2,2-dialkyl-2,3-dihydrobenzofurans from phenols is described. In the presence of an acid catalyst phenols react with 2-aryl-2,2-dialkylacetaldehydes, prepared in good yield from 2-arylacetonitriles in 2 steps, to give 3-aryl-2,2-dialkyl-2,3-dihydrobenzofurans. Electron-donating substituents were required on the phenols in order to give 3-aryl-2,2dialkyl-2,3-dihydrobenzofurans in good yield. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.01.077

文献信息

• A convenient ring formation of 3-aryl-2,2-dialkyl-2,3-dihydrobenzofurans from phenols and 2-aryl-2,2-dialkylacetaldehydes
  作者：Makoto Yamashita、Yujirou Ono、Hiroyuki Tawada

  DOI：10.1016/j.tet.2004.01.077

  日期：2004.3

  A new and simple route for the preparation of 3-aryl-2,2-dialkyl-2,3-dihydrobenzofurans from phenols is described. In the presence of an acid catalyst phenols react with 2-aryl-2,2-dialkylacetaldehydes, prepared in good yield from 2-arylacetonitriles in 2 steps, to give 3-aryl-2,2-dialkyl-2,3-dihydrobenzofurans. Electron-donating substituents were required on the phenols in order to give 3-aryl-2,2dialkyl-2,3-dihydrobenzofurans in good yield. (C) 2004 Elsevier Ltd. All rights reserved.