Ethyl 2-[(2-piperidin-1-ylacetyl)amino]benzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Ethyl 2-[(2-piperidin-1-ylacetyl)amino]benzoate
• 化学式: C₁₆H₂₂N₂O₃
• 分子量: 290.36
• InChiKey: OKRXOAUNPHTBFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• AUTO-MAGNETIC METAL SALEN COMPLEX COMPOUND
  申请人：IHI Corporation

  公开号：EP2682384A1

  公开（公告）日：2014-01-08

  The molecular structures of metal-salen complexes which exerts pharmacological effects are clarified and the metal-salen complexes having such molecular structures and their derivatives are provided. A metal-salen complex compound is characterized in that a metal atom part in each of multiple molecules of the metal-salen complex or its derivative is multimerized via water.

  金属-萨伦络合物的分子结构对产生药理效应进行了澄清，并提供了具有这种分子结构的金属-萨伦络合物及其衍生物。金属-萨伦络合物化合物的特点在于，金属-萨伦络合物或其衍生物的多个分子中的金属原子部分通过水进行多聚化。
• ANTIMICROBIALS
  申请人：Eisai Co., Ltd.

  公开号：EP1033129A1

  公开（公告）日：2000-09-06

  Antimicrobials for preventing, ameliorating or treating diseases caused by Helicobacter pylori , for example, peptic ulcer and gastritis, in particular, relapsing peptic ulcer and gastritis including: (1) antimicrobials containing as the active ingredient oxethazaine represented by chemical formula (A); (2) antimicrobials containing as the active ingredients oxethazaine and proton pump inhibitors; and (3) antimicrobials containing as the active ingredients oxethazaine and antibiotics.

  用于预防、改善或治疗幽门螺旋杆菌引起的疾病，例如消化性溃疡和胃炎，特别是复发性消化性溃疡和胃炎的抗菌药，包括： (1) 以化学式(A)表示的含有奥司他嗪作为活性成分的抗菌药； (2) 以化学式(B)表示的含有奥司他嗪和质子泵抑制剂作为活性成分的抗菌药：(1) 含有化学式(A)代表的活性成分 Oxethazaine 的抗菌剂；(2) 含有活性成分 Oxethazaine 和质子泵抑制剂的抗菌剂；以及 (3) 含有活性成分 Oxethazaine 和抗生素的抗菌剂。
• POROUS CELLULOSE AGGREGATE AND MOLDING COMPOSITION THEREOF
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP1873196A1

  公开（公告）日：2008-01-02

  A porous cellulose aggregate characterized by having a secondary aggregate structure resulting from aggregation of primary cellulose particles, having a pore volume within a particle of 0.265 to 2.625 cm3/g, containing I-type crystals and having an average particle size of over 30 to 250 µm, a specific surface area of 0.1 to less than 20 m2/g, a repose angle of 25° to less than 44° and a swelling degree of 5% or more, and characterized by having the property of disintegrating in water.

  一种多孔纤维素聚合体，其特征在于具有由初级纤维素颗粒聚合而成的次级聚合体结构，颗粒内的孔隙体积为 0.265 至 2.625 cm3/g，含有 I 型晶体，平均粒径大于 30 至 250 µm，比表面积为 0.1 至小于 20 m2/g，倾角为 25 至小于 44°，膨胀度为 5%或以上，并具有遇水崩解的特性。
• CELLULOSE POWDER HAVING EXCELLENT SEGREGATION PREVENTIVE EFFECT, AND COMPOSITIONS THEREOF
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP2287234A1

  公开（公告）日：2011-02-23

  With regard to compositions derived from active ingredients and other additives in medical, food and industrial fields, there have been problems that the active ingredients cannot be uniformly mixed, and that the active ingredients become segregated and lose uniformity as the active ingredients undergo transport, input, and filling processes. There is provided a cellulose powder which improves the uniformity of compositions containing active ingredients or other additives to prevent segregation of the active ingredients, wherein the cellulose powder contains cellulose I type crystals, has an average particle diameter of less than 30 µm, a powder density of 0.1 to 0.45 g/cm3, a tapping density of 0.1 to 0.5 g/cm3, a repose angle of 35 to 50°, a specific surface of more than or equal to 0.1 m2/g and less than 20 m2/g, an internal friction angle of 36 to 42°, and is a cellulose powder including a secondary flocculation structure in which primary particles are flocculated.

  关于医疗、食品和工业领域中由活性成分和其他添加剂制成的组合物，一直存在着活性成分不能均匀混合，以及活性成分在运输、输入和灌装过程中发生分离和失去均匀性的问题。本发明提供了一种纤维素粉末，可改善含有活性成分或其他添加剂的组合物的均匀性，防止活性成分的偏析，其中纤维素粉末含有纤维素 I 型晶体，平均颗粒直径小于 30 µm，粉末密度为 0.1至0.45克/立方厘米，攻丝密度为0.1至0.5克/立方厘米，倾伏角为35至50°，比表面大于或等于0.1平方米/克但小于20平方米/克，内摩擦角为36至42°，并且是一种纤维素粉末，包括二级絮凝结构，其中初级粒子被絮凝。
• COMPOSITE PARTICLES WHICH CONTAIN BOTH CELLULOSE AND INORGANIC COMPOUND
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP2589618A1

  公开（公告）日：2013-05-08

  Provided are composite particles which exhibit excellent fluidity and high liquid retentivity and which exhibit high fluidity even in a liquid-holding sate. Also provided are composite particles which permit direct compressing in an open feed manner and which suffer from little compressing trouble and exhibit high shapability. When shaped together with an active ingredient, the composite particles provide shaped bodies which have uniform weight, uniform active ingredient content, and high hardness and which suffer from less galling.

  本发明提供的复合颗粒具有优异的流动性和高液体保持力，即使在液体保持状态下也能表现出高流动性。此外，还提供了可直接以开放式进料方式压缩的复合微粒，这种微粒几乎不会出现压缩问题，而且具有很高的成型性。当与活性成分一起成型时，复合颗粒可提供重量均匀、活性成分含量均匀、硬度高且不易咬合的成型体。