因布酰胺 | 15687-14-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 因布酰胺
• 中文别名: 乙甲丁酰胺
• 英文名称: embutramide
• 英文别名: N-[2-ethyl-2-(3-methoxyphenyl)butyl]-4-hydroxybutanamide
• CAS: 15687-14-6
• 化学式: C₁₇H₂₇NO₃
• 分子量: 293.406
• InChiKey: LMBMDLOSPKIWAP-UHFFFAOYSA-N

物化性质

• 熔点：
  70 °C
• 沸点：
  496.7±40.0 °C(Predicted)
• 密度：
  1.038±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• Compositions for repairing and regenerating human dura mater
  申请人：BAXTER INTERNATIONAL INC.

  公开号：EP1484070A1

  公开（公告）日：2004-12-08

  A method of using a substantially non-porous equine collagen foil to repair and regenerate dura mater tissue of mammals when the dura mater tissue is damaged as a result of injury, tumors, surgery, and the like. The non-porous equine collagen foil comprises collagen fibrils which provides a replacement dura mater composition that is elastic, liquid-tight, and which has a high tensile strength. The non-porous equine collagen foil is furthermore resorbable and provides a biomatrix, wherein a neodura is rapidly formed which becomes indistinguishable from the autologous dura mater in a matter of weeks. The process for making the equine collagen foil reduces the likelihood of disease transmission.

  当哺乳动物的硬脑膜组织因损伤、肿瘤、手术等原因受损时，使用一种基本无孔的马胶原蛋白箔修复和再生硬脑膜组织的方法。无孔马胶原蛋白箔由胶原纤维组成，可提供具有弹性、液密性和高拉伸强度的替代硬脑膜组合物。此外，无孔马胶原蛋白箔还具有可吸收性，提供了一种生物基质，可迅速形成新硬脑膜，并在数周内变得与自体硬脑膜无异。马胶原蛋白箔的制作过程降低了疾病传播的可能性。
• USE OF A NEW ISOLATE OF NEOSPORA CANINUM FOR THE DEVELOPMENT OF DIAGNOSTIC TESTS AND FOR PREPARATION OF PRODUCTS FOR TREATMENT AND PREVENTION OF THE INFECTION CAUSED BY NEOSPORA
  申请人：Universidad Complutense de Madrid

  公开号：EP2196532A1

  公开（公告）日：2010-06-16

  The present invention relates to the use of a new isolate of Neospora caninum for the development of diagnostic tests and for the manufacture of products for the treatment and prevention of the infection caused by Neospora. The use of a new isolate of Neospora caninum (filed in the Culture Collection of Algae and Protozoa, with access number CCAP 2051/1), and the extracts obtained therefrom, in the preparation of diagnostic tests and in the manufacture of products for the treatment and prevention of the infection caused by Neospora, is based on the ease with which the new isolate converts from the tachyzoite to the bradyzoite stage under in vitro conditions. Additionally and with the same applications, the polypeptides and the polynucleotides obtained from the new isolate and the immunoreactive antibodies developed against Neospora antigens are used.

  本发明涉及利用一种新的犬新孢子虫分离物开发诊断检测方法，以及生产治疗和预防由新孢子虫引起的感染的产品。新孢子虫新分离物（已在藻类和原生动物培养物保藏中心备案，保藏号为 CCAP 2051/1）及其提取物可用于制备诊断检测试剂以及生产治疗和预防由新孢子虫引起的感染的产品，这是因为新分离物在体外条件下很容易从速生虫阶段转化为缓生虫阶段。此外，从新分离株中获得的多肽和多核苷酸，以及针对新孢子虫抗原开发的免疫活性抗体，也用于同样的用途。
• PHARMACEUTICAL COMPOSITION PROVIDED WITH ABUSE-PREVENTION FUNCTION
  申请人：Daiichi Sankyo Co., Ltd.

  公开号：EP3175845A1

  公开（公告）日：2017-06-07

  An object of the present invention is to provide a pharmaceutical composition having abuse deterrent properties and thereby prevent the abuse of a pharmacologically active component by an abuser (abuse through snorting, abuse through injection, or abuse through snorting or injection of a temporarily extracted drug). The present invention provides a pharmaceutical composition having abuse deterrent properties that possesses both a physical barrier and a chemical barrier to being abused by an abuser, a method for producing the same and a method for using the same.

  本发明的目的是提供一种具有阻止滥用特性的药物组合物，从而防止药理活性成分被滥用者滥用（通过吸食滥用、通过注射滥用或通过吸食或注射临时提取的药物滥用）。本发明提供了一种具有阻止滥用特性的药物组合物，这种组合物具有物理屏障和化学屏障，可防止滥用者滥用，还提供了一种生产这种组合物的方法和一种使用这种组合物的方法。
• Pharmaceutical composition having abuse deterrent properties
  申请人：Daiichi Sankyo Company, Limited

  公开号：US10172806B2

  公开（公告）日：2019-01-08

  An object of the present invention is to provide a pharmaceutical composition having abuse deterrent properties and thereby prevent the abuse of a pharmacologically active component by an abuser (abuse through snorting, abuse through injection, or abuse through snorting or injection of a temporarily extracted drug). The present invention provides a pharmaceutical composition having abuse deterrent properties that possesses both a physical barrier and a chemical barrier to being abused by an abuser, a method for producing the same and a method for using the same.

  本发明的目的是提供一种具有阻止滥用特性的药物组合物，从而防止药理活性成分被滥用者滥用（通过吸食滥用、通过注射滥用或通过吸食或注射临时提取的药物滥用）。本发明提供了一种具有阻止滥用特性的药物组合物，这种组合物具有物理屏障和化学屏障，可防止滥用者滥用，还提供了一种生产这种组合物的方法和一种使用这种组合物的方法。