1-benzyl-3-(2,2-diphenylpent-4-enyl)urea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-benzyl-3-(2,2-diphenylpent-4-enyl)urea
• 英文别名: 1-Benzyl-3-(2,2-diphenylpent-4-enyl)urea
• 化学式: C₂₅H₂₆N₂O
• 分子量: 370.494
• InChiKey: GXCGCWZMXUIJKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-benzyl-3-(2,2-diphenylpent-4-enyl)urea 在 N-碘代丁二酰亚胺 、 碳酸氢钠 作用下， 以 乙腈 为溶剂， 反应 3.0h， 以38%的产率得到2-benzyl-6,6-diphenyltetrahydro-1H-pyrrolo[1,2-c]imidazol-3(2H)-one
  参考文献：
  名称：

  Intramolecular aminochalcogenation and diamination of alkenes employing N-iodosuccinimide

  摘要：

  A NIS-mediated intramolecular diamination and aminosulfuration of alkenes with N-alkyl or N-aryl thioureas is reported. A chiral cyclic thiourea was also synthesized by the methodology. The protocol is also proven to be efficient in the intramolecular diamination and/or aminooxygenation of alkenes with N-alkyl or N-aryl ureas and ones with N-carbamate sulfamides. The resulting bicyclic thiourea could be further transformed into bicyclic guanidine. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.01.154
• 作为产物：
  描述：

  2,2-diphenyl-4-pentenylamine 、 异氰酸苄酯 以 乙醇 、 甲苯 为溶剂， 以78.4%的产率得到1-benzyl-3-(2,2-diphenylpent-4-enyl)urea
  参考文献：
  名称：

  Intramolecular aminochalcogenation and diamination of alkenes employing N-iodosuccinimide

  摘要：

  A NIS-mediated intramolecular diamination and aminosulfuration of alkenes with N-alkyl or N-aryl thioureas is reported. A chiral cyclic thiourea was also synthesized by the methodology. The protocol is also proven to be efficient in the intramolecular diamination and/or aminooxygenation of alkenes with N-alkyl or N-aryl ureas and ones with N-carbamate sulfamides. The resulting bicyclic thiourea could be further transformed into bicyclic guanidine. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.01.154

文献信息

• Intramolecular aminochalcogenation and diamination of alkenes employing N-iodosuccinimide
  作者：Jun Zhang、Xuejun Zhang、Weijie Wu、Gengtao Zhang、Sheng Xu、Min Shi

  DOI：10.1016/j.tetlet.2015.01.154

  日期：2015.3

  A NIS-mediated intramolecular diamination and aminosulfuration of alkenes with N-alkyl or N-aryl thioureas is reported. A chiral cyclic thiourea was also synthesized by the methodology. The protocol is also proven to be efficient in the intramolecular diamination and/or aminooxygenation of alkenes with N-alkyl or N-aryl ureas and ones with N-carbamate sulfamides. The resulting bicyclic thiourea could be further transformed into bicyclic guanidine. (C) 2015 Elsevier Ltd. All rights reserved.