1-[4-(3-phenylpropyl)piperidin-1-yl]octan-3-one

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-[4-(3-phenylpropyl)piperidin-1-yl]octan-3-one
• 化学式: C₂₂H₃₅NO
• 分子量: 329.526
• InChiKey: GBCZOCSGSPXTLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  24
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-[4-(3-phenylpropyl)piperidin-1-yl]octan-3-one 、 正戊基溴化镁 在 氮气 、 silica 作用下， 以 四氢呋喃 为溶剂， 生成 6-{2-[4-(3-phenylpropyl)-piperidin-1-yl]ethyl}undecan-6-ol
  参考文献：
  名称：

  Piperidine derivatives and cosmetic compositions thereof

  摘要：

  本发明提供了公式（I）的哌啶衍生物：其盐和光学异构体以及含有它们的化妆品组合物。

  公开号：

  US08129409B2
• 作为产物：
  描述：

  4-(3-苯丙基)哌啶 、 1-辛烯-3-酮 在 silica 作用下， 以 乙醇 为溶剂， 生成 1-[4-(3-phenylpropyl)piperidin-1-yl]octan-3-one
  参考文献：
  名称：

  Piperidine derivatives and cosmetic compositions thereof

  摘要：

  本发明提供了公式（I）的哌啶衍生物：其盐和光学异构体以及含有它们的化妆品组合物。

  公开号：

  US08129409B2

文献信息

• Haircare use of cyclic amine derivatives
  申请人：Cavezza Alexandre

  公开号：US20060193804A1

  公开（公告）日：2006-08-31

  The present invention relates to a process for treating human keratin fibers and/or the skin from which the said fibers emerge, in order to induce and/or stimulate the growth of the human keratin fibers and/or to stop their loss and/or to increase their density, comprising at least the application, to the human keratin fibers and/or the skin, of a cosmetic composition comprising an effective amount of at least one piperidine derivative of general formula (I), in which: R 1 denotes a halogen or a radical chosen from a linear or branched C 1 -C 6 alkyl radical, a group OR, a group NRR′, a CF 3 group, a group NHCOR or a group CONRR′; R 2 denotes a linear or branched C 1 -C 20 alkyl or alkenyl radical, the hydrocarbon-based chain of which may be optionally interrupted with a —CO— function optionally substituted with at least one group OR, COOR, NRR′, NHCOR or CONRR′ and/or with a phenyl group optionally substituted with one or more radicals R 1 ; with R and R′ denoting, independently of each other, a hydrogen atom or a linear or branched C 1 -C 6 alkyl radical, m represents an integer ranging from 0 to 5; and n represents an integer ranging from 0 to 5. or a salt or isomer thereof, leaving the said composition in contact with the keratin fibers and/or the skin from which the fibers emerge, and optionally rinsing the keratin fibers and/or the skin.

  本发明涉及一种处理人类角蛋白纤维和/或这些纤维生长的皮肤的方法，以诱导和/或刺激人类角蛋白纤维的生长和/或阻止它们的脱落和/或增加它们的密度，包括至少将含有至少一种一般式(I)的哌啶衍生物的有效量的化妆品组合物施用于人类角蛋白纤维和/或皮肤，其中： R1表示卤素或从线性或支链的C1-C6烷基基团、OR基团、NRR′基团、CF3基团、NHCOR基团或CONRR′基团中选择的基团； R2表示线性或支链的C1-C20烷基或烯基基团，其碳氢基链可以选配地被具有至少一个OR、COOR、NRR′、NHCOR或CONRR′基团和/或一个苯基（该苯基可以选择地被一个或多个基团R1取代）的—CO—功能中断，其中R和R′独立地表示氢原子或线性或支链的C1-C6烷基基团，m表示一个范围从0到5的整数；n表示一个范围从0到5的整数，或者其盐或异构体，将该组合物留在与角蛋白纤维和/或这些纤维生长的皮肤接触，然后选择性地冲洗角蛋白纤维和/或皮肤。
• [EN] COSMETIC USE OF PIPERIDINE DERIVATIVES<br/>[FR] UTILISATION COSMETIQUE DE DERIVES DE LA PIPERIDINE
  申请人：OREAL

  公开号：WO2005123678A1

  公开（公告）日：2005-12-29

  The present invention relates to the cosmetic use, as an agent for combating wrinkles, especially expression wrinkles, and/or for decontracting the skin and/or relaxing the features, of at least one piperidine derivative chosen from the compounds of formula (I) and the salts and optical isomers thereof. The invention also relates to novel piperidine der vatives, and also to cosmetic compositions containing them.

  本发明涉及一种化妆品用途，作为一种用于对抗皱纹，特别是表情皱纹，并/或用于舒缓皮肤和/或放松面部的剂，所述剂至少包括从式(I)化合物中选择的哌啶衍生物及其盐和光学异构体。该发明还涉及新型哌啶衍生物，以及含有它们的化妆品组合物。
• Cosmetic Use of Piperidine Derivatives
  申请人：Cavezza Alexandre

  公开号：US20080090866A1

  公开（公告）日：2008-04-17

  The present invention relates to the cosmetic use, as an agent for combating wrinkles, especially expression wrinkles, and/or for dencontracting the skin and/or relaxing the features, of at least one piperidine derivative chosen from the compounds of formula (I): and the salts and optical isomers thereof. The invention also relates to novel piperidine derivatives and also to cosmetic compositions containing them.

  本发明涉及化妆品用途，作为一种对抗皱纹的剂，特别是表情皱纹，和/或用于松弛皮肤和/或放松面部特征的代理，至少包括式(I)化合物的哌啶衍生物之一和其盐和光学异构体。本发明还涉及新颖的哌啶衍生物，以及含有它们的化妆品组合物。
• Cosmetic use of piperidine derivatives
  申请人：L'Oreal

  公开号：US07807695B2

  公开（公告）日：2010-10-05

  The present invention relates to the cosmetic use, as an agent for combating wrinkles, especially expression wrinkles, and/or for dencontracting the skin and/or relaxing the features, of at least one piperidine derivative chosen from the compounds of formula (I): and the salts and optical isomers thereof. The invention also relates to novel piperidine derivatives and also to cosmetic compositions containing them.

  本发明涉及化妆品用途，用作抗皱剂，特别是表情皱纹，和/或用于去除皮肤收缩和/或放松面部特征的剂量，其中至少包含从式(I)的化合物中选择的至少一种哌啶衍生物和其盐和光学异构体。本发明还涉及新的哌啶衍生物，以及含有它们的化妆品组合物。
• PIPERIDINE DERIVATIVES AND COSMETIC COMPOSITIONS THEREOF
  申请人：CAVEZZA Alexandre

  公开号：US20100267770A1

  公开（公告）日：2010-10-21

  The present invention provides piperidine derivatives of formula (I): salts and optical isomers thereof and cosmetic compositions containing them.

  本发明提供了式（I）的哌啶衍生物：其盐和光学异构体以及含有它们的化妆品组合物。