壬基十一烷基邻苯二甲酸酯 | 65185-89-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 壬基十一烷基邻苯二甲酸酯
• 英文名称: Nonyl undecyl phthalate
• 英文别名: 1-O-nonyl 2-O-undecyl benzene-1,2-dicarboxylate
• CAS: 65185-89-9
• 化学式: C₂₈H₄₆O₄
• 分子量: 446.7
• InChiKey: ACBFJMAXNZVRRX-UHFFFAOYSA-N

物化性质

• 沸点：
  454.2±13.0 °C(Predicted)
• 密度：
  0.966±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿（少许）、乙酸乙酯（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  11.2
• 重原子数：
  32
• 可旋转键数：
  22
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Short duration depot formulations
  申请人：——

  公开号：US20040001889A1

  公开（公告）日：2004-01-01

  Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a short duration of time. The compositions include a low molecular weight biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

  本文描述了系统性或局部通过植入给予有益药物的方法和组合物，其中包括例如可注射到所需位置的储库凝胶组合物，可以在短时间内提供有益药物的控制释放。该组合物包括低分子量生物相容性聚合物、生物相容性溶剂，具有低水溶性，与聚合物形成黏稠的凝胶，并限制植入物的吸水性，以及有益药物。
• SHORT DURATION DEPOT FORMULATIONS
  申请人：Chen Guohua

  公开号：US20060165800A1

  公开（公告）日：2006-07-27

  Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a short duration of time. The compositions include a low molecular weight biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

  本文描述了用于系统性或局部通过植入向受体施用有益剂的方法和组合物，其中包括例如可注入到所需位置的蓄积凝胶组合物，其可以在短时间内控制释放有益剂。该组合物包括低分子量生物相容性聚合物、生物相容性溶剂，具有低水亲和性，与聚合物形成粘稠凝胶，并限制了植入物的吸水，以及有益剂。
• Controlled release depot formulations
  申请人：——

  公开号：US20040151753A1

  公开（公告）日：2004-08-05

  Methods and compositions for systemically or locally administering a beneficialagent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a prolonged duration of time. The compositions include a biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

  本文描述了用于系统性或局部给受体注射有益药物的方法和组合物，包括可以注射到所需位置并可以在较长时间内控制释放有益药物的沉积凝胶组合物。该组合物包括生物相容性聚合物、生物相容性溶剂（具有低水亲和性，与聚合物形成粘稠的凝胶并限制植入物的吸水量）和有益药物。
• Injectable multimodal polymer depot compositions and uses thereof
  申请人：——

  公开号：US20040022859A1

  公开（公告）日：2004-02-05

  Injectable depot compositions are provided that include a polymer matrix having a plurality of bioerodible, biocompatible polymers wherein wherein each polymer of the plurality of polymers has a specified weight average molecular weight; and the polymer matrix has a broad molecular weight distribution of the plurality of polymers; a solvent having a miscibility in water of less than or equal to 7 wt. % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith; and a beneficial agent. The compositions are have substantially improved the shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patient's body surface by injection.

  提供可注射的缓释剂组合物，其包括具有多种可生物降解、生物相容性聚合物的聚合物基质，其中多种聚合物中的每一种聚合物具有规定的重均分子量；并且聚合物基质具有多种聚合物的宽分子量分布；一种具有在25℃下水中溶解度小于或等于7重量％的溶剂，其数量足以使聚合物增塑并与之形成凝胶；以及一种有益的药剂。这些组合物具有明显改善的剪切变薄行为和减少的注射力，使它们可以通过注射轻松地植入病人身体表面下。
• PROCESS FOR PRODUCING EXPANDABLE STYRENE POLYMER COMPOSITIONS
  申请人：Husemann Wolfram

  公开号：US20110291040A1

  公开（公告）日：2011-12-01

  A composition comprising at least one expandable styrene polymer component and at least one cyclohexanecarboxylic ester and also optionally further components can be processed to mechanically robust foam materials.

  本发明涉及一种组合物，包括至少一种可膨胀苯乙烯聚合物组分和至少一种环己烷羧酸酯，还可以选择性地加入其他组分，可加工成具有机械强度的泡沫材料。