2-[(2,3,4-Trimethoxybenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(2,3,4-Trimethoxybenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
• 化学式: C₁₉H₂₂N₂O₅S
• 分子量: 390.5
• InChiKey: UAUXUKJRGDTSDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  128
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• INHIBITORS OF MICROBIALLY INDUCED AMYLOID
  申请人：Axial Biotherapeutics, Inc.

  公开号：US20200290970A1

  公开（公告）日：2020-09-17

  The present disclosure provides compounds useful for the prevention of amyloid formation and the treatment of amyloid related disorders, including synucleopathies such as Parkinson's Disease.

  本公开提供了用于预防淀粉样蛋白形成和治疗与淀粉样蛋白相关疾病的化合物，包括如帕金森病这样的突触核蛋白病。
• Inhibitors of microbially induced amyloid
  申请人：Axial Therapeutics, Inc.

  公开号：US11505528B2

  公开（公告）日：2022-11-22

  The present disclosure provides compounds useful for the prevention of amyloid formation and the treatment of amyloid related disorders, including synucleopathies such as Parkinson's Disease.

  本公开提供了可用于预防淀粉样蛋白形成和治疗淀粉样蛋白相关疾病（包括帕金森病等突触核病）的化合物。
• SUSTAINED RELEASE SOLID DOSAGE FORMS FOR MODULATING THE COLONIC MICROBIOME
  申请人：Axial Therapeutics, Inc.

  公开号：US20210052503A1

  公开（公告）日：2021-02-25

  Described are sustained-release solid dosage forms of epigallocatechin gallate (EGCG) or aminosterol compositions. In one aspect of the invention the sustained-release solid dosage forms of EGCG or an aminosterol are capsules comprising a plurality of coated solid particulates. Another aspect of the invention relates to methods of inhibiting, ameliorating, reducing the likelihood of, delaying the onset of, treating or preventing an amyloid disorder, comprising the step of administering to a subject in need a therapeutically effective amount of the solid dosage form. In certain aspects, the amyloid disorder is Parkinson's Disease.
• [EN] INHIBITORS OF MICROBIALLY INDUCED AMYLOID<br/>[FR] INHIBITEURS DE LA FORMATION D'AMYLOÏDES INDUITE PAR VOIE MICROBIENNE
  申请人：AXIAL BIOTHERAPEUTICS INC

  公开号：WO2019028456A1

  公开（公告）日：2019-02-07

  The present disclosure provides compounds useful for the prevention of amyloid formation and the treatment of amyloid related disorders, including synucleopathies such as Parkinson's Disease.
• [EN] SUSTAINED RELEASE SOLID DOSAGE FORMS FOR MODULATING THE COLONIC MICROBIOME<br/>[FR] FORMES POSOLOGIQUES SOLIDES À LIBÉRATION PROLONGÉE POUR MODULER LE MICROBIOME DU CÔLON
  申请人：AXIAL BIOTHERAPEUTICS INC

  公开号：WO2020227437A1

  公开（公告）日：2020-11-12

  Described are sustained-release solid dosage forms of epigallocatechin gallate (EGCG) or amino sterol compositions. In one aspect of the invention the sustained-release solid dosage forms of EGCG or an amino sterol are capsules comprising a plurality of coated solid particulates. Another aspect of the invention relates to methods of inhibiting, ameliorating, reducing the likelihood of, delaying the onset of, treating or preventing an amyloid disorder, comprising the step of administering to a subject in need a therapeutically effective amount of the solid dosage form. In certain aspects, the amyloid disorder is Parkinson's Disease.