1,6-diamino-4-(2-methoxynaphthalen-1-yl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1,6-diamino-4-(2-methoxynaphthalen-1-yl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile
• 英文别名: 1,2-Diamino-4-(2-methoxynaphthalen-1-yl)-6-oxopyridine-3,5-dicarbonitrile；1,2-diamino-4-(2-methoxynaphthalen-1-yl)-6-oxopyridine-3,5-dicarbonitrile
• 化学式: C₁₈H₁₃N₅O₂
• 分子量: 331.334
• InChiKey: SFFBRCTVSKZIIZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  129
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-甲氧基-1-萘醛 在 哌啶 、 三乙胺 作用下， 以 乙醇 为溶剂， 反应 5.0h， 生成 1,6-diamino-4-(2-methoxynaphthalen-1-yl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile
  参考文献：
  名称：

  Synthesis and Antimicrobial Evaluation of Some New Dihydropyridine, Pyrazole, Chromene, Pyrrole, Thiazole and Thiophene Derivatives

  摘要：

  Synthesis of 2-cyano-N((2-methoxynaphthalen-1-yl)methylene)acetohydrazide (3) and its use as a key intermediate for the synthesis of some new heterocyclic compounds such as dihydropyridines (4, 6 and 8), pyrazoles (9 and 10), chromene (11), pyrroles (12 and 13), thiazoles (14 and 17) and thiophene (18-20) derivatives were described. The structures of newly synthesized compounds have been established on the basis of their IR, H-1-NMR, C-13-NMR and mass spectral data and have been screened for their antimicrobial activity.

  DOI：

  10.3987/com-14-13072

文献信息

• Synthesis and Antimicrobial Evaluation of Some New Dihydropyridine, Pyrazole, Chromene, Pyrrole, Thiazole and Thiophene Derivatives
  作者：Ahmed A. Fadda、Hala M. Refat、Khaled S. Mohamed、Nada A. H. Mohamed

  DOI：10.3987/com-14-13072

  日期：——

  Synthesis of 2-cyano-N((2-methoxynaphthalen-1-yl)methylene)acetohydrazide (3) and its use as a key intermediate for the synthesis of some new heterocyclic compounds such as dihydropyridines (4, 6 and 8), pyrazoles (9 and 10), chromene (11), pyrroles (12 and 13), thiazoles (14 and 17) and thiophene (18-20) derivatives were described. The structures of newly synthesized compounds have been established on the basis of their IR, H-1-NMR, C-13-NMR and mass spectral data and have been screened for their antimicrobial activity.