N-[2-{(4-propionyloxyphenyl)thio}ethyl]propionamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: N-[2-{(4-propionyloxyphenyl)thio}ethyl]propionamide
• 英文别名: [4-[2-(Propanoylamino)ethylsulfanyl]phenyl] propanoate
• 化学式: C₁₄H₁₉NO₃S
• 分子量: 281.376
• InChiKey: KLPORYPYENOKBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  80.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-乙基-2-唑啉 在 吡啶 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 30.0h， 生成 N-[2-{(4-propionyloxyphenyl)thio}ethyl]propionamide
  参考文献：
  名称：

  A Simple and Efficient Synthesis ofN‐[2‐{(4‐Propionyloxyphenyl)thio}ethyl]propionamide (DIPCAP), a Tyrosine‐Dependent Cytotoxic Agent as a Topical Antimelanoma Therapy

  摘要：

  The synthesis of N-[2-{(4-propionyloxyphenyl)thio}ethyl]propionamide (DIPCAP), a tyrosine-dependent cytotoxic agent that is currently being evaluated as a topical antimelanoma treatment is described. Problems encountered in scaling up the original patent procedure have been eliminated and DIPCAP was obtained in an overall yield of 65% from commercially available starting materials.

  DOI：

  10.1081/scc-200026188

文献信息

• A Simple and Efficient Synthesis of<i>N</i>‐[2‐{(4‐Propionyloxyphenyl)thio}ethyl]propionamide (DIPCAP), a Tyrosine‐Dependent Cytotoxic Agent as a Topical Antimelanoma Therapy
  作者：Lisa D. Coutts、Harold Meckler、Karl F. Popp

  DOI：10.1081/scc-200026188

  日期：2004.1

  The synthesis of N-[2-(4-propionyloxyphenyl)thio}ethyl]propionamide (DIPCAP), a tyrosine-dependent cytotoxic agent that is currently being evaluated as a topical antimelanoma treatment is described. Problems encountered in scaling up the original patent procedure have been eliminated and DIPCAP was obtained in an overall yield of 65% from commercially available starting materials.