3-(2-nitro-anilino)-propane-1,2-diol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(2-nitro-anilino)-propane-1,2-diol
• 英文别名: 3-(2-Nitro-anilino)-propan-1,2-diol；3-(2-Nitroanilino)-1,2-propanediol；3-(2-nitroanilino)propane-1,2-diol
• 化学式: C₉H₁₂N₂O₄
• 分子量: 212.205
• InChiKey: WKSAPOUMJXDCPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  98.3
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1,2-环氧-3-(2-硝基苯氧基)丙烷 在 乙醇 、 氨 作用下， 生成 3-(2-nitro-anilino)-propane-1,2-diol
  参考文献：
  名称：

  Petrow; Stephenson, Journal of Pharmacy and Pharmacology, 1953, vol. 5, p. 359,366

  摘要：

  DOI：

文献信息

• Prodrugs of a 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
  申请人：Sugen. Inc.

  公开号：US20030100555A1

  公开（公告）日：2003-05-29

  The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

  本发明涉及吡咯替代的2-吲哚酮化合物及其药学上可接受的盐，这些化合物调节蛋白激酶的活性，因此预计在预防和治疗蛋白激酶相关的细胞疾病，如癌症方面具有用处。
• Phosphate mimics and methods of treatment using phosphatease inhibitors
  申请人：Sugen, Inc.

  公开号：US20040138255A1

  公开（公告）日：2004-07-15

  The invention relates to trifluoromethyl sulfonyl and trifluoromethyl sulfonamido compounds and the physiologically acceptable salts and the prodrugs thereof. These compounds are expected to modulate the activity of protein tyrosine enzymes which are related to cellular signal transduction, in particular, protein tyrosine phosphatase, and therefore are expected to be useful in the prevention and treatment of disorders associated with abnormal protein tyrosine enzyme related cellular signal transduction such as cancer, diabetes, immuno-modulation, neurologic degenerative diseases, osteoporosis and infectious diseases. The invention also relates to the use of compounds containing fluoromethyl sulfonyl groups as phosphate mimics. These mimics may be used to inhibit, regulate or modulate the activity of a phosphate binding protein in a cell.

  本发明涉及三氟甲基磺酰和三氟甲基磺酰胺化合物及其生理上可接受的盐和前药。这些化合物预计能够调节与细胞信号转导相关的蛋白酪氨酸酶的活性，特别是蛋白酪氨酸磷酸酶，因此预计在预防和治疗与异常蛋白酪氨酸酶相关的细胞信号转导障碍，如癌症、糖尿病、免疫调节、神经退行性疾病、骨质疏松症和传染病方面有用。本发明还涉及含有氟甲基磺酰基团的化合物作为磷酸酯模拟物的用途。这些模拟物可用于抑制、调节或调节细胞中的磷酸结合蛋白的活性。
• Dye composition for Keratinous fibers
  申请人：Kao Corporation

  公开号：EP0547790A1

  公开（公告）日：1993-06-23

  A dye composition for keratinous fibers characterized by comprising the following ingredients (A), (B) and (C) : (A) a direct dye, (B) a polyoxyalkylene modified organopolysiloxane which contains 3 to 30% by weight of a polyoxyalkylene group in a molecule thereof, and is dispersible in water, (C) an organic solvent, and having a PH of 2.0 to 4.5. The dye composition according to the present invention is excellent in the dyeing performance, and since it imparts excellent conditiong effects to the hair, the feel to the touch of the hair during rinsing and drying is quite favorable.

  一种用于角质纤维的染料组合物，其特征在于包含以下成分 (A)、(B) 和 (C) ： (A) 直接染料、 (B) 聚氧亚烷基改性有机聚硅氧烷，其分子中含有 3%至 30%（按重量计）的聚 氧亚烷基，并可分散于水中、 (C) 有机溶剂、 PH 值为 2.0 至 4.5。 本发明的染料组合物具有优异的染色性能，而且由于其对头发具有优异的护理效果，在漂洗和干燥过程中头发的触感也非常好。
• Photochemistry of riboflavine. IV. Photobleaching of some nitrogen-9 substituted isoalloxazines and flavines
  作者：William Marshall Moore、Charles Baylor

  DOI：10.1021/ja01053a048

  日期：1969.12
• Synthese Lactoflavin-ähnlicher Verbindungen
  作者：P. Karrer、H. Salomon、K. Schöpp、E. Schlittler

  DOI：10.1002/hlca.193401701144

  日期：——