(3R,5S)-5-(2,5-Difluoro-4-methoxy-benzyloxymethyl)-1-(2-methoxy-pyrimidin-4-yl)-pyrrolidine-3-thiol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3R,5S)-5-(2,5-Difluoro-4-methoxy-benzyloxymethyl)-1-(2-methoxy-pyrimidin-4-yl)-pyrrolidine-3-thiol
• 英文别名: (3R,5S)-5-[(2,5-difluoro-4-methoxyphenyl)methoxymethyl]-1-(2-methoxypyrimidin-4-yl)pyrrolidine-3-thiol
• 化学式: C₁₈H₂₁F₂N₃O₃S
• 分子量: 397.446
• InChiKey: VPNROZRRPDMWDL-QWHCGFSZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  57.7
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Pyrrolidine derivatives
  申请人：——

  公开号：US20020055632A1

  公开（公告）日：2002-05-09

  The present invention relates to pyrrolidine derivatives useful as inhibitors of metalloproteases, e.g. zinc proteases, and which are effective in treating disease states associated with vasoconstriction.

  本发明涉及吡咯烷衍生物，可用作金属蛋白酶抑制剂，例如锌蛋白酶，并且对治疗与血管收缩相关的疾病状态有效。
• PYRIMIDINE DERIVATIVES
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1303507A1

  公开（公告）日：2003-04-23
• US6660738B2
  申请人：——

  公开号：US6660738B2

  公开（公告）日：2003-12-09
• [EN] PYRIMIDINE DERIVATIVES<br/>[FR] DERIVES DE PYRIMIDINE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2002006271A1

  公开（公告）日：2002-01-24

  The present invention relates to compounds of formula (I) wherein R?1, R2, R3, R4, X1, X2, X3, X4¿ and Y are as defined in the description and the claims and dimeric forms and/or pharmaceutically acceptable esters, and/or salts thereof. The compounds are useful as inhibitors of metalloproteases, e.g. zinc proteases, particularly zinc hydrolases, and which are effective in treating disease states are associated with vasoconstriction of increasing occurrences.