(E)-1-(4-carboxylphenyl)-1-pentene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-1-(4-carboxylphenyl)-1-pentene
• 英文别名: ((E)-4-pent-1-enyl)-benzoic acid；4-pent-1-enyl-benzoic acid；4-(Pent-1-en-1-yl)benzoic acid；4-[(E)-pent-1-enyl]benzoic acid
• 化学式: C₁₂H₁₄O₂
• 分子量: 190.242
• InChiKey: WPYZZVKPJHDAOE-SNAWJCMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-formyl-benzoic acid 在 硫酸 作用下， 以 水 为溶剂， 反应 0.5h， 生成 (E)-1-(4-carboxylphenyl)-1-pentene
  参考文献：
  名称：

  [EN] AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME
  [FR] DERIVES D'AMIDE UTILISES COMME LIGANDS DU CANAL IONIQUE ET COMPOSITIONS PHARMACEUTIQUES ET METHODES D'UTILISATION DE CES DERIVES

  摘要：

  揭示了具有以下公式表示的化合物：公式（I）。这些化合物可以制备为药物组合物，并可用于预防和治疗包括人类在内的哺乳动物的各种疾病，例如疼痛、炎症、创伤性损伤等。

  公开号：

  WO2005046683A1

文献信息

• METHOD FOR PRODUCING PERFLUOROALKYLATED COMPOUND
  申请人：RIKEN

  公开号：US20200277243A1

  公开（公告）日：2020-09-03

  Provided is a method for producing a perfluoroalkylated compound at low cost, safely and with high efficiency. A method for producing a perfluoroalkylated compound, comprising reacting a bis(perfluoroalkanoyl) peroxide with a compound having a carbon-carbon unsaturated bond and/or an aromatic ring having a hydrogen atom bonded thereto in the presence of a copper catalyst.

  提供了一种以低成本、安全且高效的方式生产全氟烷基化合物的方法。一种生产全氟烷基化合物的方法，包括在铜催化剂存在下，将双(全氟脂肪酰)过氧化物与含有碳-碳不饱和键和/或芳香环且其中有氢原子与之键合的化合物反应。
• New carboxamide compounds having melanin concentrating hormone antagonistic activity, pharmaceutical preparations comprising these compounds and process for their manufacture
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20040242572A1

  公开（公告）日：2004-12-02

  The present invention relates to carboxamide compounds of general formula I 1 wherein the groups and residues A, B, W, X, Y, Z, R 1 , R 2 , R 3 and k have the meanings given in claim 1. Moreover the invention relates to process for preparing the above mentioned carboxamides as well as pharmaceutical compositions containing at least one carboxamide according to the invention. In view of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.

  本发明涉及具有通式I的羧酰胺化合物 1 其中，A、B、W、X、Y、Z、R 1 、R 2 、R 3 和k的含义如权利要求1中所述。此外，本发明还涉及制备上述羧酰胺的方法以及含有至少一种根据本发明的羧酰胺的药物组合物。由于它们对MCH受体的拮抗活性，根据本发明的药物组合物适合用于治疗代谢紊乱和/或饮食紊乱，特别是肥胖症、厌食症、暴食症、糖尿病。
• AMIDE DERIVATIVES AS ION CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME
  申请人：Kelly G Michael

  公开号：US20050222200A1

  公开（公告）日：2005-10-06

  Abstract of the Disclosure Compounds are disclosed that have a formula represented by Formula I herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

  本披露的化合物具有以下式表示的化学式I。这些化合物可制备为药物组合物，并可用于预防和治疗哺乳动物包括人类的各种疾病，包括但不限于疼痛、炎症、创伤性损伤等。
• Catalyst systems based on transition metal complexes for carbon monoxide copolymerization in an aqueous medium
  申请人：——

  公开号：US20040092682A1

  公开（公告）日：2004-05-13

  Catalyst systems for the copolymerization of carbon monoxide and &agr;-olefinically unsaturated compounds contain, as essential components, a) a metal complex of the formula (I) 1 where R 1 to R 4 are each linear or branched C 2 - to C 28 -alkyl, C 3 - to C 14 -cycloalkyl or alkylaryl where the alkyl moiety is of 1 to 28 carbon atoms and the aryl moiety is of 6 to 15 carbon atoms, each of which is substituted by at least one polar protic or ionic functional group based on elements of groups IVA to VIA of the Periodic Table of Elements, and b) if required, one or more Lewis or protic acids or a mixture of Lewis and protic acids.

  催化剂系统用于一氧化碳和α-烯烃不饱和化合物的共聚反应，其包含以下必要组分：a）化学式（I）1的金属配合物，其中R1至R4均为直链或支链的C2至C28烷基，C3至C14环烷基或烷基芳基，其中烷基部分为1至28个碳原子，芳基部分为6至15个碳原子，每个基团上至少含有一种基于元素周期表IVA至VIA元素群的极性质子或离子官能基；以及b）如有需要，一种或多种路易斯酸或质子酸，或路易斯酸和质子酸的混合物。
• Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
  申请人：Kelly Michael G.

  公开号：US20080312237A1

  公开（公告）日：2008-12-18

  Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

  揭示了具有以下公式表示的化合物：这些化合物可以制备为药物组成，可用于哺乳动物包括人类的预防和治疗各种病症，包括但不限于疼痛、炎症、创伤损伤等。