Thiazolo[5,4-c]pyridin-4-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Thiazolo[5,4-c]pyridin-4-amine
• 英文别名: [1,3]thiazolo[5,4-c]pyridin-4-amine
• 化学式: C₆H₅N₃S
• 分子量: 151.19
• InChiKey: DTORQMGJINOVCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  80
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• METHOD FOR TREATING IMMUNE TOXICITIES INDUCED BY IMMUNE CHECKPOINT INHIBITORS
  申请人：Assistance Publique Hôpitaux de Paris

  公开号：EP3944859A1

  公开（公告）日：2022-02-02

  The invention relates to the use of a JAK inhibitor for treating or preventing adverse events in patient treated with an immune checkpoint inhibitor, or for treating cancer in combination with an immune checkpoint inhibitor.

  本发明涉及使用JAK抑制剂治疗或预防接受免疫检查点抑制剂治疗的患者的不良反应，或与免疫检查点抑制剂联合治疗癌症。
• METHODS OF TREATING DISEASES CHARACTERIZED BY EXCESSIVE WNT SIGNALLING
  申请人：The Walter and Eliza Hall Institute of Medical Research

  公开号：EP2981252A1

  公开（公告）日：2016-02-10
• [EN] METHODS OF TREATING DISEASES CHARACTERIZED BY EXCESSIVE WNT SIGNALLING<br/>[FR] MÉTHODES DE TRAITEMENT DE MALADIES CARACTÉRISÉES PAR UNE SIGNALISATION WNT EXCESSIVE
  申请人：INST MEDICAL W & E HALL

  公开号：WO2014161046A1

  公开（公告）日：2014-10-09

  The present invention relates to a method of treating or preventing a disease characterized by excessive Wnt signalling, such as colorectal cancer, by administering a compound which inhibits the activity of one or more of JAK2, JAKl or TYK2.
• [EN] METHOD FOR TREATING IMMUNE TOXICITIES INDUCED BY IMMUNE CHECKPOINT INHIBITORS<br/>[FR] PROCÉDÉ DE TRAITEMENT DE TOXICITÉS IMMUNITAIRES INDUITES PAR DES INHIBITEURS DE POINTS DE CONTRÔLE IMMUNITAIRES
  申请人：HOPITAUX PARIS ASSIST PUBLIQUE

  公开号：WO2022023490A1

  公开（公告）日：2022-02-03

  The invention relates to the use of a JAK inhibitor for treating or preventing adverse events in patient treated with an immune checkpoint inhibitor, or for treating cancer in combination with an immune checkpoint inhibitor.