奥洛他定杂质B | 173174-07-7

• 物质功能分类: 分析化学 - 标准品 - 药典标准品和杂质标准品
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噁庚英
• 中文名称: 奥洛他定杂质B
• 中文别名: 奥洛他定相关物质B；奥洛他定N-氧化物
• 英文名称: Olopatadine N-Oxide
• 英文别名: (3Z)-3-[2-(carboxymethyl)-6H-benzo[c][1]benzoxepin-11-ylidene]-N,N-dimethylpropan-1-amine oxide
• CAS: 173174-07-7
• 化学式: C21H23NO4
• 分子量: 353.4
• InChiKey: TXKZPVWYFNGMCP-LSCVHKIXSA-N

物化性质

• 溶解度：
  乙醇（稍微加热）、甲醇（稍微加热）、水（稍微加热）

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• DISPENSING DEVICE AND PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF RHINITIS
  申请人：Glenmark Specialty S.A.

  公开号：EP3468532A1

  公开（公告）日：2019-04-17
• [EN] FORMULATION OF OLOPATADINE<br/>[FR] FORMULATION D'OLOPATADINE
  申请人：NEPHRON PHARMACEUTICALS CORP

  公开号：WO2015065576A1

  公开（公告）日：2015-05-07

  Stable formulations of Olopatadine, methods of making such formulations and methods of treatment using such formulations are provided.
• [EN] DISPENSING DEVICE AND PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF RHINITIS<br/>[FR] DISPOSITIF DE DISTRIBUTION ET COMPOSITION PHARMACEUTIQUE POUR LE TRAITEMENT DE LA RHINITE
  申请人：GLENMARK SPECIALTY SA

  公开号：WO2019006173A1

  公开（公告）日：2019-01-03

  A nasal dispensing device and pharmaceutical composition includes a container; a dispenser head having at least a pump, a dispensing channel, and a dispensing orifice; a dip tube; and a pharmaceutical composition comprising mometasone, an ester thereof (e.g., mometasone furoate), or a salt thereof and olopatadine or its salt (e.g., olopatadine hydrochloride). The container can have a conically shaped internal bottom, angled downwardly toward a center, and a further angularly deepened well, centrally located, with the dip tube extending into the well. An optional cap is provided that includes a sealing sleeve communicating in a seal tight manner with a perimeter of a lateral wall of the dispenser head.