Asenapine and related trans-isomer bicyclic compounds can be obtained by reducing a compound of formula (C) to preferentially form a trans-isomer compound of formula (D), followed by subsequent ring closure to form a compound of formula (B) such as asenapine.
Asenapine和相关的顺式异构体
双环化合物可以通过还原式(C)式化合物,优先形成式(D)式的顺式异构体化合物,然后通过后续的环闭合反应形成式(B)式化合物,如asenapine。