6-(2-(2,2,2-trifluoroacetyl)hydrazinyl)nicotinic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-(2-(2,2,2-trifluoroacetyl)hydrazinyl)nicotinic acid
• 英文别名: 6-[2-(Trifluoroacetyl)hydrazino]nicotinic acid；6-[2-(2,2,2-trifluoroacetyl)hydrazinyl]pyridine-3-carboxylic acid
• 化学式: C₈H₆F₃N₃O₃
• mdl: MFCD03678598
• 分子量: 249.149
• InChiKey: QBHBUBYFACXPQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  91.3
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  6-(2-(2,2,2-trifluoroacetyl)hydrazinyl)nicotinic acid 在 盐酸 作用下， 反应 1.0h， 以88%的产率得到6-肼基烟酸
  参考文献：
  名称：

  Trifluoroacetyl-HYNIC Peptides:  Synthesis and ^99mTc Radiolabeling

  摘要：

  Fmoc-lys(HYNIC-Boc)-OH, a precursor for solid-phase synthesis of Tc-99m-labeled peptides, was synthesized efficiently without HPLC purification. HPLC-ESMS showed that deprotection and decoupling of peptide from the resin with trifluoroacetic acid gave initially HYNIC-peptide, which was trifluoroacetylated upon prolonged incubation. The trifluoroacetyl-HYNIC group was hydrolyzed during Tc-99m labeling, rendering deprotection unnecessary. Trifluoroacetyl-HYNIC peptide was Tc-99m-labeled as efficiently, producing the same product, as HYNIC-peptide. These modifications enhance the versatility of HYNIC for Tc-99m peptide labeling.

  DOI：

  10.1021/jm061274l
• 作为产物：
  描述：

  三氟乙酸 、 6-[2-(叔丁氧羰基)肼基]烟酸 反应 15.0h， 以78%的产率得到6-(2-(2,2,2-trifluoroacetyl)hydrazinyl)nicotinic acid
  参考文献：
  名称：

  Trifluoroacetyl-HYNIC Peptides:  Synthesis and ^99mTc Radiolabeling

  摘要：

  Fmoc-lys(HYNIC-Boc)-OH, a precursor for solid-phase synthesis of Tc-99m-labeled peptides, was synthesized efficiently without HPLC purification. HPLC-ESMS showed that deprotection and decoupling of peptide from the resin with trifluoroacetic acid gave initially HYNIC-peptide, which was trifluoroacetylated upon prolonged incubation. The trifluoroacetyl-HYNIC group was hydrolyzed during Tc-99m labeling, rendering deprotection unnecessary. Trifluoroacetyl-HYNIC peptide was Tc-99m-labeled as efficiently, producing the same product, as HYNIC-peptide. These modifications enhance the versatility of HYNIC for Tc-99m peptide labeling.

  DOI：

  10.1021/jm061274l

文献信息

• TECHNETIUM-99m COMPLEX AS A TOOL FOR THE IN VIVO DIAGNOSIS OF CANCEROUS TUMOURS
  申请人：Guminski Yves

  公开号：US20130171067A1

  公开（公告）日：2013-07-04

  The invention relates to a compound having formula (I), compositions containing same and preparation methods thereof. The invention also relates to a complex of the compound having formula (I) with technetium-99m and tricine, the use of this complex as a diagnostic probe, diagnostic compositions containing same and methods for preparing the complex and compositions containing same.

  该发明涉及具有化学式（I）的化合物，含有该化合物的组合物以及其制备方法。该发明还涉及具有化学式（I）的化合物与锝-99m和三甘氨酸的复合物，该复合物作为诊断探针的用途，含有相同化合物的诊断组合物以及制备该复合物和含有相同化合物的组合物的方法。
• TRIFUNCTIONAL CROSSLINKING REAGENTS
  申请人：ETH Zurich

  公开号：EP2942351B1

  公开（公告）日：2016-10-12
• US9766235B2
  申请人：——

  公开号：US9766235B2

  公开（公告）日：2017-09-19
• Trifluoroacetyl-HYNIC Peptides:  Synthesis and ^99mTc Radiolabeling
  作者：M. Bashir-Uddin Surfraz、Robert King、Stephen J. Mather、Stefano C. G. Biagini、Philip J. Blower

  DOI：10.1021/jm061274l

  日期：2007.3.1

  Fmoc-lys(HYNIC-Boc)-OH, a precursor for solid-phase synthesis of Tc-99m-labeled peptides, was synthesized efficiently without HPLC purification. HPLC-ESMS showed that deprotection and decoupling of peptide from the resin with trifluoroacetic acid gave initially HYNIC-peptide, which was trifluoroacetylated upon prolonged incubation. The trifluoroacetyl-HYNIC group was hydrolyzed during Tc-99m labeling, rendering deprotection unnecessary. Trifluoroacetyl-HYNIC peptide was Tc-99m-labeled as efficiently, producing the same product, as HYNIC-peptide. These modifications enhance the versatility of HYNIC for Tc-99m peptide labeling.