季铵盐-51 | 1463-95-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 季铵盐-51
• 英文名称: 1-ethyl-2-[2-(5-bromo-[2]pyridylamino)-vinyl]-6-methyl-pyridinium; iodide
• 英文别名: 1-Aethyl-2-[2-(5-brom-[2]pyridylamino)-vinyl]-6-methyl-pyridinium; Jodid；6-[2-[(5-bromo-2-pyridyl)amino]vinyl]-1-ethyl-2-picolinium iodide；Quaternium 51；5-bromo-N-[2-(1-ethyl-6-methylpyridin-1-ium-2-yl)ethenyl]pyridin-2-amine;iodide
• CAS: 1463-95-2
• 化学式: C₁₅H₁₇BrN₃*I
• 分子量: 446.129
• InChiKey: FEYNAYMVKUTMFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.55
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  28.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  N,N'-bis-(5-chloro-[2]pyridyl)-formamidine 、 季铵盐-51 生成 1-ethyl-2-[2-(5-bromo-[2]pyridylamino)-vinyl]-6-[2-(5-chloro-[2]pyridylamino)-vinyl]-pyridinium; iodide
  参考文献：
  名称：

  Telomerase inhibitors

  摘要：

  There has been a vast increase in telomerase research over the past several years, with many different pre-clinical approaches being tested for inhibiting the activity of this enzyme as a novel therapeutic modality to treat malignancy. In this review, we will provide some basic background information about telomeres and telomerase and then discuss the pros, cons and challenges of the approaches that are currently under investigation, and what we might expect in the future of this emerging field.

  DOI：

  10.1016/s0167-7799(00)01541-9
• 作为产物：
  描述：

  N,N'-Bis-(5-brom-pyridyl-2)-formamidin 、 N-ethyl-2,6-dimethylpyridinium iodide 生成 季铵盐-51
  参考文献：
  名称：

  Telomerase inhibitors

  摘要：

  There has been a vast increase in telomerase research over the past several years, with many different pre-clinical approaches being tested for inhibiting the activity of this enzyme as a novel therapeutic modality to treat malignancy. In this review, we will provide some basic background information about telomeres and telomerase and then discuss the pros, cons and challenges of the approaches that are currently under investigation, and what we might expect in the future of this emerging field.

  DOI：

  10.1016/s0167-7799(00)01541-9

文献信息

• Alpha-Isomaltosylglucosaccharide synthase, process for producing the same and use thereof
  申请人：——

  公开号：US20030194762A1

  公开（公告）日：2003-10-16

  The object of the present invention is to provide an &agr;-isomaltosylglucosaccharide-forming enzyme, process of the same, cyclotetrasaccharide, and saccharide composition comprising the saccharide which are obtainable by using the enzyme; and is solved by establishing an &agr;-isomaltosylglucosaccharide-forming enzyme which forms a saccharide, having a glucose polymerization degree of at least three and having both the &agr;-1,6 glucosidic linkage as a linkage at the non-reducing end and the &agr;-1,4 glucosidic linkage other than the linkage at the non-reducing end, by catalyzing the &agr;-glucosyl-transfer from a saccharide having a glucose polymerization degree of at least two and having the &agr;-1,4 glucosidic linkage as a linkage at the non-reducing end without substantially increasing the reducing power; &agr;-isomaltosyl-transferring method using the enzyme; method for forming &agr;-isomaltosylglucosaccharide; process for producing a cyclotetrasaccharide having the structure of cyclo{→6)-&agr;-D-glucopyranosyl-(1→3)-&agr;-D-glucopyranosyl-(1→6)-&agr;-D-glucopyranosyl-(1→3)-&agr;-D-glucopyranosyl-(1→} using both the &agr;-isomaltosylglucosaccharide-forming enzyme and the &agr;-isomaltosyl-transferring enzyme; and the uses of the saccharides obtainable therewith.

  本发明的目的是提供一种α-异麦芽糊精葡萄糖醛酸形成酶、其制备方法、环四糖和含有使用该酶可获得的糖分的糖组成物；并通过建立一种α-异麦芽糊精葡萄糖醛酸形成酶来解决该问题，该酶可形成一种葡萄糖聚合度至少为三且具有α-1,6葡萄糖苷键作为非还原端连接和α-1,4葡萄糖苷键作为非还原端连接以外的连接的糖分，通过催化具有至少二个葡萄糖聚合度且具有α-1,4葡萄糖苷键作为非还原端连接的糖分的α-葡萄糖基转移而形成，而不实质性地增加还原能力；使用该酶的α-异麦芽糊精转移方法；形成α-异麦芽糊精葡萄糖醛酸的方法；使用α-异麦芽糊精葡萄糖醛酸形成酶和α-异麦芽糊精转移酶同时制备具有环四糖结构的环四糖的方法；以及使用可获得的糖分的用途。
• Sugar derivative
  申请人：——

  公开号：US20040254367A1

  公开（公告）日：2004-12-16

  For extending the uses of a compound represented by, Chemical formula 1, the object of the present invention is to provide a derivative of cyclic tetrasaccharide whose physicochemical properties are changed from those of cyclic tetrasaccaride, a composition comprising the same, and a process for producing the same. The present invention solves the above object by providing a derivative of cyclic tetrasaccharide, which is produced by the steps of reacting a compound represented by Chemical formula 1 with a reactive reagent and substituting one ore more hydroxyl groups with substituents except hydroxyl group and O-glycosyl group; a composition comprising the same; and a process for producing the derivative of cyclic tetrasaccharide. Chemical formula 1 1

  为了扩展化学式1所代表的化合物的用途，本发明的目的是提供一种环状四糖衍生物，其物理化学性质与环状四糖不同，以及包含该衍生物的组合物和制备该衍生物的方法。本发明通过以下步骤提供一种环状四糖衍生物：将化学式1代表的化合物与反应试剂反应，并用除了羟基和O-糖基以外的取代基替换一个或多个羟基；包含该衍生物的组合物；以及制备环状四糖衍生物的方法。化学式11。
• A low-frequency therapeutic device for iontophoresing cation and anion
  申请人：Hayashibara, Ken

  公开号：EP0230153A1

  公开（公告）日：1987-07-29

  A low-frequency therapeutic device for iontophoresing cation and anion comprises a low-frequency generator (A) and a switch (Si-S3), e.g. a rotary switch, to select the polarity of the low-frequency voltage. The switch (S1) is operable in association with the on/off operation of a power source (B), and an active electrode (E, F) is connected by way of the switch (S1-S3 to the output of the low-frequency generator (A). The device is to be used to improve the efficacy of the iontophoresis of a liquid medicine including cationic and anionic el- elemts.

  一种用于离子渗透阳离子和阴离子的低频治疗装置包括一个低频发生器（A）和一个开关（Si-S3），例如一个旋转开关，用于选择低频电压的极性。开关 (S1) 与电源 (B) 的开/关操作相关联，有源电极 (E, F) 通过开关 (S1-S3) 连接到低频发生器 (A) 的输出端。 该装置用于提高包括阳离子和阴离子元素在内的液体药物的离子渗透疗效。
• Propolis extract with improved water-solubility
  申请人：KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO

  公开号：EP0867187A1

  公开（公告）日：1998-09-30

  Disclosed are a propolis extract which is prepared by adjusting the pH of propolis to 5.5-7.0 to improve the water-solubility of the effective ingredients of propolis, a composition containing the propolis extract, and a method for improving the water-solubility of propolis extracts.

  本发明公开了一种通过将蜂胶的 pH 值调节至 5.5-7.0 以改善蜂胶有效成分的水溶性而制备的蜂胶提取物、一种含有该蜂胶提取物的组合物，以及一种改善蜂胶提取物水溶性的方法。
• Composition for inhibiting body odor and uses thereof
  申请人：KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO

  公开号：EP1129693A2

  公开（公告）日：2001-09-05

  Disclosed are a composition for inhibiting body odor which comprises trehalose and/or maltitol as an effective ingredient, a method for inhibiting body odor by using the composition, and an article incorporated with the composition.

  本发明公开了一种抑制体臭的组合物（其有效成分包括树胶糖和/或麦芽糖醇）、一种使用该组合物抑制体臭的方法，以及一种含有该组合物的物品。