3-chloro-4-methoxy-N-(2-nitrophenyl)aniline

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-chloro-4-methoxy-N-(2-nitrophenyl)aniline
• 化学式: C13H11ClN2O3
• 分子量: 278.69
• InChiKey: PNRJCRUEFNVACN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  67.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] COMPOUNDS<br/>[FR] COMPOSES
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2002040467A1

  公开（公告）日：2002-05-23

  2-Pyridyl substituted benzimidazole compounds of formula (I), wherein R1 is phenyl or naphthyl optionally substituted with one or more substituents selected from halo, C¿1-6?alkoxy, C1-6akylthio, C1-6haloalkyl, -O-(CH2)m-Ph, -S-(CH2)m-Ph, cyano, phenyl, and CO2R, wherein R is hydrogen or C1-6alkyl and m is 0-3; or phenyl fused with a 5-to 7-membered aromatic or non-aromatic ring wherein said ring contains up to three heteroatoms, independently selected from N, O and S; and R?2¿ represents one or more substituents independently selected from C¿1-6?alkyl, C1-6alkoxy, C1-6haloalkyl, halo, NH2, NH-C1-6alkyl or NH(CH2)n-Ph wherein n is 0-3 and salts and solvates thereof are disclosed, as are methods for their preparation, pharmaceutical compositions containing them and their use in medicine.