1-(2-chlorophenyl)-1-(4-methoxyphenyl)ethane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-chlorophenyl)-1-(4-methoxyphenyl)ethane
• 英文别名: 1-Chloro-2-[1-(4-methoxyphenyl)ethyl]benzene
• 化学式: C₁₅H₁₅ClO
• 分子量: 246.737
• InChiKey: FWIAPUGFIXHICY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-(2-氯苯基)乙醇 、 苯甲醚 在 碘 作用下， 反应 6.0h， 以88%的产率得到1-(2-chlorophenyl)-1-(4-methoxyphenyl)ethane
  参考文献：
  名称：

  Molecular iodine-catalyzed benzylation of arenes with benzyl alcohols

  摘要：

  A novel molecular iodine-catalyzed benzylation of arenes with benzyl alcohols has been developed. The reaction can be carried out under mild conditions to afford a series of diarymethane derivatives in high yields and good regioselectivities. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.05.146

文献信息

• Nickel‐Catalyzed Chain‐Walking Cross‐Electrophile Coupling of Alkyl and Aryl Halides and Olefin Hydroarylation Enabled by Electrochemical Reduction
  作者：Gadde Sathish Kumar、Anatoly Peshkov、Aleksandra Brzozowska、Pavlo Nikolaienko、Chen Zhu、Magnus Rueping

  DOI：10.1002/anie.201915418

  日期：2020.4.16

  novel route to afford 1,1-diarylalkane derivatives from simple and readily available alkyl and aryl halides in good yields and excellent regioselectivities under mild conditions. The procedure shows good tolerance for a broad variety of functional groups and both primary and secondary alkyl halides can be used. Furthermore, the reaction was successfully scaled up to the multigram scale proving the

  开发了第一种用于镍催化的交叉亲电子偶联的电化学方法。该方法提供了一种新颖的途径，可以在温和的条件下，以简单的，容易获得的烷基和芳基卤化物以良好的收率和优异的区域选择性来制备1,1-二芳基烷烃衍生物。该方法显示出对多种官能团的良好耐受性，并且可以使用伯烷基卤和仲烷基卤。此外，该反应已成功扩大到数克规模，证明了其在工业应用中的潜力。机理研究表明，在电还原链走芳基化反应中形成了氢化镍，这导致了新的苯乙烯催化的镍催化加氢芳基化反应的进一步发展，提供了一系列1，
• An Efficient and Selective Hydroarylation of Styrenes with Electron-Rich Arenes, Catalyzed by Bismuth(III) Chloride and Affording Markovnikov Adducts
  作者：Hong-Bin Sun、Biao Li、Ruimao Hua、Yingwu Yin

  DOI：10.1002/ejoc.200600390

  日期：2006.9

  In the presence of BiCl3, the hydroarylation of styrenes with electron-rich arenes afforded Markovnikov adducts selectively in good to high yields. Under arene-free conditions, the intermolecular hydroarylation of α-substituted styrenes and subsequent intramolecular hydroarylation produced the cyclic dimers of α-substituted styrenes in good yields. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim

  在 BiCl3 存在下，苯乙烯与富电子芳烃的加氢芳基化以良好到高产率选择性地提供马尔科夫尼科夫加合物。在无芳烃的条件下，α-取代苯乙烯的分子间加氢芳基化和随后的分子内加氢芳基化以良好的产率产生了α-取代苯乙烯的环状二聚体。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
• A Novel InCl₃/SiO₂-Catalyzed Hydroarylation of Arenes with Styrenes under Solvent-Free Conditions
  作者：Zhiyong Wang、Ming-Ming Zhou、Gaojun Sun、Huayin Sun

  DOI：10.1055/s-2008-1042917

  日期：——

  A novel InCl 3 /SiO 2 -catalyzed hydroarylation of various styrenes with arenes has been developed. The reaction can be carried out under solvent-free conditions to afford a series of 1,1-di-arylalkanes in high yields and with good regioselectivities. The catalyst can be reused six times without obvious loss of catalytic activity.

  已开发出一种新型 InCl 3 /SiO 2 催化的各种苯乙烯与芳烃的加氢芳基化反应。该反应可以在无溶剂条件下进行，以高产率和良好的区域选择性得到一系列 1,1-二-芳基烷烃。该催化剂可重复使用6次，催化活性无明显损失。
• Molecular iodine-catalyzed benzylation of arenes with benzyl alcohols
  作者：Gaojun Sun、Zhiyong Wang

  DOI：10.1016/j.tetlet.2008.05.146

  日期：2008.8

  A novel molecular iodine-catalyzed benzylation of arenes with benzyl alcohols has been developed. The reaction can be carried out under mild conditions to afford a series of diarymethane derivatives in high yields and good regioselectivities. (C) 2008 Elsevier Ltd. All rights reserved.