(+)-(1-羟基-2,2,5,5-四甲基吡咯烷-3-基)甲基甲烷硫代磺酸酯 | 681034-14-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: (+)-(1-羟基-2,2,5,5-四甲基吡咯烷-3-基)甲基甲烷硫代磺酸酯
• 英文名称: (+)-(1-Oxyl-2,2,5,5-tetramethylpyrrolidin-3-YL)methyl methanethiosulfonate
• 英文别名: (1-hydroxy-2,2,5,5-tetramethylpyrrolidin-3-yl)methoxy-methyl-oxo-sulfanylidene-λ6-sulfane
• CAS: 681034-14-0
• 化学式: C₁₀H₂₁NO₃S₂
• 分子量: 267.4
• InChiKey: FEEBHMJXHAORCL-UHFFFAOYSA-N

物化性质

• 熔点：
  85-90°C
• 溶解度：
  可溶于氯仿、DMSO、乙醇

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  90.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• COMPOSITIONS AND METHODS TO ASSESS THE CAPACITY OF HDL TO SUPPORT REVERSE CHOLESTEROL TRANSPORT
  申请人：Oda Michael N.

  公开号：US20140162376A1

  公开（公告）日：2014-06-12

  The invention provides compositions and methods for assessing the capacity of high density lipoprotein (HDL) to support reverse cholesterol transport in blood by measuring exchange if HDL-specific spin-labeled lipoprotein probes and electron paramagnetic spectroscopy. The invention also provides methods to identify individuals at risk for cardiovascular disease, to monitor the treatment of cardiovascular disease and in the development of therapies to treat cardiovascular disease. The invention also provides methods to identify individuals at risk for Alzheimer's disease, to monitor the treatment of Alzheimer's disease and in the development of therapies to treat Alzheimer's disease.