(1-乙基己基)邻苯二甲酸氢酯 | 23276-77-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (1-乙基己基)邻苯二甲酸氢酯
• 英文名称: (+/-)-phthalic acid mono-(1-ethyl-hexyl ester)
• 英文别名: (+/-)-Phthalsaeure-mono-(1-aethyl-hexylester)；Phthalsaeure-mono-(1-aethyl-hexylester)；(1-ethylhexyl) hydrogen phthalate；Mono(1-ethylhexyl) phthalate；2-octan-3-yloxycarbonylbenzoic acid
• CAS: 23276-77-9
• 化学式: C₁₆H₂₂O₄
• 分子量: 278.348
• InChiKey: SVRGUNPFMROZBU-UHFFFAOYSA-N

物化性质

• 沸点：
  408.9±28.0 °C(Predicted)
• 密度：
  1.088±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2922509090

反应信息

• 作为产物：
  描述：

  苯酐 、 3-辛醇 生成 (1-乙基己基)邻苯二甲酸氢酯
  参考文献：
  名称：

  Patel; Joshi; Chudasama, Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 2008, vol. 47, # 3, p. 348 - 352

  摘要：

  DOI：

文献信息

• Dominant role of an endothelium-derived hyperpolarizing factor (EDHF)-like vasodilator in the ciliary vascular bed of the bovine isolated perfused eye
  作者：Alister J McNeish、William S Wilson、William Martin

  DOI：10.1038/sj.bjp.0704332

  日期：2001.10

  The roles of the endothelium‐derived nitric oxide, prostacyclin and endothelium‐derived hyperpolarizing factor (EDHF) in mediating vasodilator responses to acetylcholine and bradykinin were assessed in the ciliary vascular bed of the bovine isolated perfused eye preparation. Vasodilatation to acetylcholine or bradykinin was unaffected by the nitric oxide synthase inhibitor, L‐NAME (100 μM), or the cyclo‐oxygenase inhibitor, flurbiprofen (30 μM), but was virtually abolished following treatment with a high concentration of KCl (30 mM), or by damaging the endothelium with the detergent, CHAPS (0.3%, 2 min). Acetylcholine‐induced vasodilatation was unaffected by glibenclamide (10 μM), an inhibitor of ATP‐sensitive K+ channels (K+ATP), but was significantly attenuated by TEA (10 mM), a non‐selective inhibitor of K+ channels. The small conductance calcium‐sensitive K+ channel (SK+Ca) inhibitor, apamin (100 nM), and the large conductance calcium‐sensitive K+ channel (BK+Ca) inhibitor, iberiotoxin (50 nM), had no significant effect on acetylcholine‐induced vasodilatation. In contrast, the intermediate (IK+Ca)/large conductance calcium‐sensitive K+ channel inhibitor, charybdotoxin (50 nM), powerfully blocked these vasodilator responses, and uncovered a vasoconstrictor response. The combination of apamin (100 nM) with a sub‐threshold concentration of charybdotoxin (10 nM) significantly attenuated acetylcholine‐induced vasodilatation, but the combination of apamin (100 nM) with iberiotoxin (50 nM) had no effect. In conclusion, blockade by a high concentration of KCl, by charybdotoxin, or by the combination of apamin with a sub‐threshold concentration of charybdotoxin, strongly suggests that vasodilatation in the bovine isolated perfused eye is mediated by an EDHF. British Journal of Pharmacology (2001) 134, 912–920; doi:10.1038/sj.bjp.0704332

  以下是中文翻译： 评估了来自内皮的NO、前列环素和内皮源性超极化因子（EDHF）在介导乙酰胆碱和缓激肽引发的血管舒张反应中的作用，实验对象为牛孤立灌注眼的睫状血管床。 乙酰胆碱或缓激肽引起的血管舒张不受NO合成酶抑制剂（L-NAME，100 μM）或环氧化酶抑制剂（flurbiprofen，30 μM）的影响，但在给予高浓度KCl（30 mM）或使用洗涤剂CHAPS（0.3%，2 min）破坏内皮后，血管舒张几乎完全消失。 乙酰胆碱诱导的血管舒张不受ATP敏感型K+通道抑制剂（glibenclAMide，10 μM）的影响，但在给予非选择性K+通道抑制剂（TEA，10 mM）后显著减弱。 小导电钙敏感型K+通道（SK+Ca）抑制剂（apAMin，100 nM）和大导电钙敏感型K+通道（BK+Ca）抑制剂（iberiotoxin，50 nM）对乙酰胆碱诱导的血管舒张无显著影响。相比之下，中/大导电钙敏感型K+通道抑制剂（charybdotoxin，50 nM）强烈阻断了这些血管舒张反应，并揭示了血管收缩反应。 apAMin（100 nM）与sub-threshold浓度的charybdotoxin（10 nM）组合显著减弱乙酰胆碱诱导的血管舒张，而apAMin（100 nM）与iberiotoxin（50 nM）组合无影响。 综上所述，高浓度KCl、charybdotoxin或apAMin与sub-threshold浓度charybdotoxin的组合对血管舒张的强烈阻断，强烈表明牛孤立灌注眼中的血管舒张是由EDHF介导的。 British Journal of Pharmacology (2001) 134, 912–920; doi:10.1038/sj.bjp.0704332
• [EN] ANTICANCER COMPOSITIONS<br/>[FR] COMPOSITIONS ANTICANCEREUSES
  申请人：RTP PHARMA INC.

  公开号：WO1999049848A1

  公开（公告）日：1999-10-07

  (EN) Pharmaceutical dosage forms for anticancer drugs, and paclitaxel in particular, are described in which the active drug is formulated as storage stable self-emulsifying preconcentrate.(FR) L'invention concerne des formes posologiques pharmaceutiques pour médicaments anticancéreux, en particulier le paclitaxel, dans lesquelles le principe actif se présente sous la forme d'un préconcentré auto-émulsifiant stable au stockage.

  制备抗癌药物的药物剂型，特别是紫杉醇，其中活性药物以储存稳定的自乳化预浓缩物的形式配制。
• Polyglycol dielectric capacitor fluid
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0058904A2

  公开（公告）日：1982-09-01

  Polypropylene glycol dielectric fluids are used to impregnate electrical capacitors and particularly metallized capacitors for improved performance.

  聚丙二醇介电流体用于浸渍电容器，特别是金属化电容器，以提高其性能。
• Safened sorptive granular pesticidal resin compositions for controlling soil borne pests and process for the preparation thereof
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0268926A2

  公开（公告）日：1988-06-01

  A pesticidal composition comprising: about 2.0% to 30.0%, by weight, of a pesticide, the technical grade of said pesticide having an acute dermal LD50 value, measured on rats or rabbits, of less than 50 mg/kg; about 5.0% to 20.0%, by weight, of a polyvinyl chloride or polyvinyl chloride/vinyl ester copolymer or homopolymer having a weight average molecular weight of about 200,000 to 400,000 and an inherent viscosity, as determined by ASTMD 1243, of about 1.00 to 1.32; about 5.0% to 15.0%, by weight, of a secondary plasticizing agent; about 0.3% to 2.0%, by weight, of a heat stabilizing agent for said resin; about 0.5% to 2.0%, by weight, of a surface active agent; about 40.0% to 80.0%, by weight, of a solid sorptive carrier; about 0.0% to 2.0%, by weight, of a drying agent and lubricant; and about 0.0% to 6.0%, by weight, of a de­activator; wherein said pesticidal composition is a solid sorptive granular pesticidal resin composition. The compositions are characterized by markendly reduced mammalian toxicity in comparison to the technical grade pesticide.

  一种杀虫剂组合物，按重量计，包括：约 2.0%至 30.0%的杀虫剂，所述杀虫剂的技术等级在大鼠或兔子身上测得的急性经皮半数致死剂量小于 50 毫克/千克；约 5.0%至 20.0%的聚氯乙烯或聚氯乙烯/乙烯基酯共聚物或均聚物，按重量计，所述聚氯乙烯或聚氯乙烯/乙烯基酯共聚物或均聚物的重量平均分子量约为 200,000 至 400,000 且固有分子量小于 50 毫克/千克。以重量计，约 5.0%至 20.0%的聚氯乙烯或聚氯乙烯/乙烯基酯共聚物或均聚物，其重量平均分子量约为 200,000 至 400,000 且按 ASTMD 1243 测定的固有粘度约为 1.00 至 1.32以重量计，约 5.0% 至 15.0% 的二次增塑剂；以重量计，约 0.3% 至 2.0% 的用于所述树脂的热稳定剂；以重量计，约 0.5% 至 2.0% 的表面活性剂；以重量计，约 40.0% 至 80.0%(重量)的固体吸附载体；约0.0%至2.0%(重量)的干燥剂和润滑剂；以及约0.0%至6.0%(重量)的失活剂；其中所述杀虫剂组合物是固体吸附颗粒杀虫剂树脂组合物。 与工业级杀虫剂相比，这些组合物的特点是明显降低了哺乳动物的毒性。
• Laminated structures
  申请人：KURARAY CO., LTD.

  公开号：EP0271097A2

  公开（公告）日：1988-06-15

  A laminated structure comprising a base material made of a polyvinyl chloride resin, polystyrene resin, polyacrylic resin, polycarbonate resin or polyamide resin; having pro­vided on at least one surface thereof a layer of a blend of a polyesteramide and an EVOH. In this laminated structure the base material layer and the EVOH layer adhere firmly to each other. The structure is excellent in gas barrier properties, prevention of plasticizer bleeding and soil prevention, and is useful as wall paper, portfolio, desk mat, etc.

  一种层压结构，包括由聚氯乙烯树脂、聚苯乙烯树脂、聚丙烯酸树脂、聚碳酸酯树脂或聚酰胺树脂制成的基材；在其至少一个表面上有一层聚酯酰胺和乙烯-环氧乙烷的混合物。在这种层压结构中，基材层和 EVOH 层牢固地粘在一起。这种结构在气体阻隔性、防止增塑剂渗出和防污方面性能优异，可用作墙纸、文件夹、桌垫等。