(1-溴辛基)苯 | 1228032-66-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (1-溴辛基)苯
• 英文名称: (1-bromooctyl)benzene
• 英文别名: 1-Bromooctylbenzene
• CAS: 1228032-66-3
• 化学式: C₁₄H₂₁Br
• 分子量: 269.225
• InChiKey: PPNPQNOFGDUIOT-UHFFFAOYSA-N

物化性质

• 沸点：
  307.0±11.0 °C(Predicted)
• 密度：
  1.144±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  辛烯 、 三丁基苯基锡 在 双(乙腈)氯化钯(II) 、 copper(ll) bromide 作用下， 以 乙醚 为溶剂， 反应 12.0h， 以45%的产率得到(1-溴辛基)苯
  参考文献：
  名称：

  Palladium-Catalyzed Oxidative Arylhalogenation of Alkenes: Synthetic Scope and Mechanistic Insights

  摘要：

  This article describes the development of a Pd-catalyzed reaction for the arylhalogenation (halogen = Cl or Br) of diverse alpha-olefins by oxidatively intercepting Mizoroki-Heck intermediates. These transformations afford synthetically useful 1,2- and 1,1-arylhalogenated products in good yields with good to excellent selectivities that can be modulated by changing the nature of the halogenating reagent and/or the reaction conditions. The selectivity of these reactions can be rationally tuned by (i) controlling the relative rates of oxidative functionalization versus beta-hydride elimination from equilibrating Pd-II-alkyl species and (ii) stabilization of organometallic Pd-II intermediates through the formation of pi-benzyl adducts. These arylhalogenations exhibit modest to excellent levels of stereoselectivity, and the key carbon-halogen bond-forming step proceeds with predominant retention of stereochemistry at carbon.

  DOI：

  10.1021/ja101851v

文献信息

• CARBAZOLE COMPOUND HAVING ANTI-VIRUS ACTIVITY
  申请人：KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

  公开号：US20180057527A1

  公开（公告）日：2018-03-01

  The present invention relates to a carbazole compound having anti-virus activity, and more particularly, to a novel compound selected from the group of consisting of a carbazole compound which shows excellent anti-proliferative efficacy against hepatitis C virus (HCV), a pharmaceutically acceptable salt thereof, a hydrate thereof, and an isomer thereof; an anti-virus pharmaceutical composition including the novel compound as an active ingredient; a pharmaceutical composition for preventing or treating liver diseases caused by hepatitis C virus; and a method of preparing the novel compound.

  本发明涉及一种具有抗病毒活性的咔唑化合物，更具体地说，涉及一种从咔唑化合物组中选择的新化合物，该化合物对丙型肝炎病毒（HCV）表现出优异的抗增殖功效，其药用盐、水合物和异构体；包括该新化合物作为活性成分的抗病毒药物组合物；用于预防或治疗由丙型肝炎病毒引起的肝病的药物组合物；以及制备该新化合物的方法。
• Removal of Bromine From Gaseous Hydrogen Bromide
  申请人：Albermarle Corporation

  公开号：US20150147265A1

  公开（公告）日：2015-05-28

  Processes of and systems for removing free bromine from gaseous anhydrous HBr contaminated with free bromine are described. In one type of process the gaseous contaminated HBr is fed into countercurrent contact with at least one liquid alkylaromatic hydrocarbon within a packed section of a column while maintaining the packed section under free radical bromination conditions so that one or more than one liquid a-bromoalkylaromatic compound is produced along with one mole of gaseous HBr per mole of a-bromoalkylaromatic compound produced. In another type of process the gaseous anhydrous HBr is fed into countercurrent contact through at least two scrubbers so that the gaseous anhydrous HBr is scrubbed substantially free of bromine by passage through these at least two scrubbers, each of which contains a different specified type of scrubbing liquid. In one embodiment the liquid alkylaromatic hydrocarbon comprises 1,2-diphenylethane.

  描述了从受游离溴污染的气态无水HBr中去除游离溴的过程和系统。在一种处理过程中，将受污染的气态HBr与至少一种液态烷基芳香烃在填充柱的填充部分中逆流接触，同时保持填充部分处于自由基溴化条件下，以产生一种或多种液态α-溴代烷基芳香化合物，每摩尔α-溴代烷基芳香化合物产生一个摩尔的气态HBr。在另一种处理过程中，将气态无水HBr逆流通过至少两个洗涤器进行接触，以通过这些至少两个洗涤器使气态无水HBr基本上不含溴，每个洗涤器都包含不同指定类型的洗涤液。在一种实施例中，液态烷基芳香烃包括1,2-二苯乙烷。
• Leukotriene antagonists
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP0375348A1

  公开（公告）日：1990-06-27

  Compounds of structure (I) in which, inter alia, R is (CH₂)mCO₂H, (CH₂)mCO₂R₃, (CH₂)mCONHSO₂R₃, CH₂CH(NH₂)COR₄ or a phenyl(alkyl) or tetrazoyl ring; one of R¹ and R² is C₈₋₁₃alkyl, C₇₋₁₂alkoxy, phenyl C₄₋₁₀alkyl or phenyl C₄₋₁₀alkoxy and the other is H, Br, Cl, CH₃, CF₃, CF₃, OH, NO₂ or C₁₋₄alkoxy; R³ is alkyl, aryl or substituted aryl, R⁴ is OH or gly; R⁵ is OH, C₁₋₆alkoxy or NHSO₂R₃; m is 0 to 6; Y is (H)n(CH₂)pCONHSO₂R₃, (H)n(CH₂)p-T, (H)n(CH₂)pCO₂H or (CH)n(CH₂)pCOR₃, where T is tetrazoyl; A is H, OH, alkyl alkoxy OAc or F, n is 0 of 1 and p is 0 or 1; processes for their preparation, compositions containing them and their use in therapy as leukotriene antagonists.

  结构(I)的化合物 其中，除其他外，R 是 (CH₂)mCO₂H、(CH₂)mCO₂R₃、(CH₂)mCONHSO₂R₃、CH₂CH(NH₂)COR₄ 或苯基（烷基）或四甲酰基环；R¹ 和 R² 中的一个是 C₈₋₁₃烷基、C₇₋₁₂烷氧基、苯基 C₄₋₁₀ 烷基或苯基 C₄₋₁₀ 烷氧基，另一个是 H、Br、Cl、CH₃、CF₃、CF₃、OH、NO₂ 或 C₁₋₄ 烷氧基；R³ 是烷基、芳基或取代的芳基，R⁴ 是 OH 或 gly；R⁵ 是 OH、C₁₋₆ 烷氧基或 NHSO₂R₃；m 是 0 至 6；Y 是 (H)n(CH₂)pCONHSO₂R₃、(H)n(CH₂)p-T、 (H)n(CH₂)pCO₂H 或 (CH)n(CH₂)pCOR₃，其中 T 为四氮酰；A 为 H、OH、烷基烷氧基 OAc 或 F，n 为 0 或 1，p 为 0 或 1；它们的制备工艺、含有它们的组合物以及它们在治疗中作为白三烯拮抗剂的用途。
• Method for producing an aromatic compound having an alkyl group with at least three carbon atoms
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP0985649A2

  公开（公告）日：2000-03-15

  Aromatic compounds having an alkyl group with at least 3 carbon atoms are produced in a process comprising at least one of the following steps: (1) a step of contacting a starting material that contains an aromatic compound having a branched alkyl group with at least 3 carbon atoms, with a zeolite-containing catalyst in a liquid phase in the presence of hydrogen therein, thereby changing the position of the carbon atoms of the alkyl group bonding to the aromatic ring of the compound; (2) a step of contacting a starting material that contains an aromatic compound having a branched alkyl group with at least 3 carbon atoms, with a catalyst containing zeolite and containing rhenium and/or silver, in a liquid phase, thereby changing the position of the carbon atoms of the alkyl group bonding to the aromatic ring of the compound; (3) a step of contacting a halogenated aromatic compound having an alkyl group with at least 3 carbon atoms, with an acid-type catalyst, thereby isomerizing the compound; and (4) a step of treating a mixture of isomers of an aromatic compound having an alkyl group with at least 3 carbon atoms, with a zeolite adsorbent that contains at least one exchangable cation selected from alkali metals, alkaline earth metals, lead, thallium and silver, thereby separating a specific isomer from the isomer mixture through adsorption.

  具有至少 3 个碳原子烷基的芳香族化合物的生产工艺至少包括以下一个步骤： (1) 将含有至少 3 个碳原子的支链烷基的芳香族化合物的起始原料在液相中与含沸石的催化剂在氢存在的情况下接触，从而改变烷基的碳原子与化合物的芳香环键合的位置； (2) 将含有芳香族化合物的起始原料与含沸石和含铼和/或银的催化剂在液相中接触，该芳香族化合物具有至少 3 个碳原子的支链烷基，从而改变烷基碳原子与化合物芳香环键合的位置； (3) 将具有至少 3 个碳原子的烷基的卤代芳香族化合物与酸型催化剂接触，从而使该化合物异构化；以及 (4) 用沸石吸附剂处理具有至少 3 个碳原子的烷基的芳香族化合物的异构体混合物，该沸石吸附剂含有至少一种选自碱金属、碱土金属、铅、铊和银的可交换阳离子，从而通过吸附从异构体混合物中分离出特定的异构体。
• Carbazole compound having anti-virus activity
  申请人：KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

  公开号：US10421779B2

  公开（公告）日：2019-09-24

  The present invention relates to a carbazole compound having anti-virus activity, and more particularly, to a novel compound selected from the group of consisting of a carbazole compound which shows excellent anti-proliferative efficacy against hepatitis C virus (HCV), a pharmaceutically acceptable salt thereof, a hydrate thereof, and an isomer thereof; an anti-virus pharmaceutical composition including the novel compound as an active ingredient; a pharmaceutical composition for preventing or treating liver diseases caused by hepatitis C virus; and a method of preparing the novel compound.

  本发明涉及一种具有抗病毒活性的咔唑化合物，更具体地说，涉及一种选自以下组成的组别的新型化合物：一种对丙型肝炎病毒（HCV）具有优异抗增殖功效的咔唑化合物、其药学上可接受的盐、其水合物和其异构体；一种包括该新型化合物作为活性成分的抗病毒药物组合物；一种用于预防或治疗由丙型肝炎病毒引起的肝病的药物组合物；以及一种制备该新型化合物的方法。