(13Z)-N-(2-羟基乙基)-13-二十二碳烯酰胺 | 18190-74-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: (13Z)-N-(2-羟基乙基)-13-二十二碳烯酰胺
• 英文名称: (Z)-N-(2-hydroxyethyl)docos-13-enamide
• CAS: 18190-74-4
• 化学式: C₂₄H₄₇NO₂
• 分子量: 381.643
• InChiKey: UGYSMGXRWBTMRZ-KTKRTIGZSA-N

物化性质

• 沸点：
  533.1±33.0 °C(Predicted)
• 密度：
  0.904±0.06 g/cm3(Predicted)
• 溶解度：
  氯仿：0.3mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  27
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2924199090

反应信息

• 作为产物：
  描述：

  芥酸 在 氯化亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 生成 (13Z)-N-(2-羟基乙基)-13-二十二碳烯酰胺
  参考文献：
  名称：

  [EN] COMPOUNDS AND METHOD OF USE THEREOF FOR TREATING BACTERIAL DISEASES
  [FR] COMPOSÉS ET LEUR PROCÉDÉ D'UTILISATION POUR TRAITER DES MALADIES BACTÉRIENNES

  摘要：

  The present disclosure provides compounds that can inhibit the type III secretion system (TTSS) to decrease the pathogenesis of gram-negative bacteria. These compounds may have wide applications for treating bacteria diseases caused by gram-negative bacteria in a host species, including but not limited to, plants and animals. The present invention further relates to compositions that inhibit pathogenesis of gram-negative bacteria without killing the bacteria. Methods relating to preventing and/or treating infection of a host species by bacterial pathogens are also provided herein.

  公开号：

  WO2023104017A1

文献信息

• POWER TRANSMISSION BELT
  申请人：Mitsuboshi Belting Ltd.

  公开号：EP2711587A1

  公开（公告）日：2014-03-26

  The present invention relates to a power transmission belt containing an adhesive rubber layer having a core wire embedded therein in the longitudinal direction of the belt, a compression rubber layer formed on one surface of the adhesive rubber layer, and an extensible rubber layer formed on another surface of said adhesive rubber layer, in which at least the compression rubber layer contains a fatty acid amide and a short fiber.

  本发明涉及一种动力传输带，它包含一个粘合橡胶层，该粘合橡胶层在带的纵向方向上嵌入了芯线；一个压缩橡胶层，形成于粘合橡胶层的一个表面；以及一个可伸展橡胶层，形成于所述粘合橡胶层的另一个表面，其中至少压缩橡胶层包含脂肪酸酰胺和短纤维。
• TRANSMISSION BELT
  申请人：Mitsuboshi Belting Ltd.

  公开号：EP2843258A1

  公开（公告）日：2015-03-04

  The present invention relates to a transmission belt containing a core wire extending in a lengthwise direction of the belt, an adhesive rubber layer in contact with at least a part of the core wire, a back surface rubber layer formed on one surface of the adhesive rubber layer, and an inner surface rubber layer formed on the other surface of the adhesive rubber layer and engaging or in contact with a pulley, in which the adhesive rubber layer is formed by a vulcanized rubber composition containing a rubber component, a fatty acid amide and a silica.

  本发明涉及一种传动带，包含沿传动带长度方向延伸的芯线、与芯线至少一部分接触的粘合橡胶层、形成于粘合橡胶层一个表面的背面橡胶层以及形成于粘合橡胶层另一个表面并与滑轮啮合或接触的内面橡胶层，其中粘合橡胶层由硫化橡胶组合物形成，该组合物包含橡胶成分、脂肪酸酰胺和二氧化硅。
• LUBRICATING OIL COMPOSITION, AND SLIDING MECHANISM USING LUBRICATING OIL COMPOSITION
  申请人：Idemitsu Kosan Co., Ltd

  公开号：EP2826844A1

  公开（公告）日：2015-01-21

  Disclosed is a lubricating oil composition for low-friction sliding materials, which is used in a sliding mechanism where a DLC film containing hydrogen in an amount of from 5 atom% to 50 atom% is formed on at least one sliding surface. The lubricating oil composition contains, in the lubricant base oil therein and based on the total amount of the composition, (A) an organic zinc dithiophosphate in an amount of from 0.005% by mass to 0.12% by mass in terms of the phosphorus concentration therein, (B) an amide-based friction-reducing agent in an amount of from 0.05% by mass to 5.0% by mass, and (C) an alkaline earth metal salicylate-based detergent and/or an alkaline earth metal sulfonate-based detergent in an amount of from 0.05% by mass to 0.5o by mass in terms of the alkaline earth metal concentration therein.

  本发明公开了一种用于低摩擦滑动材料的润滑油组合物，该组合物用于在至少一个滑动表面上形成含氢量为 5 原子％至 50 原子％的 DLC 膜的滑动机构中。 该润滑油组合物在其中的润滑油基础油中，根据组合物的总量，含有 (A) 有机二硫代磷酸锌，以其中的磷浓度计，含量为 0.005% （质量分数）至 0.12% （质量分数）；(B) 酰胺基减摩剂，含量为 0.05% (质量)至 5.0% (质量)，以及 (C) 碱土金属水杨酸酯类洗涤剂和/或碱土金属磺酸盐类洗涤剂，以其中碱土金属浓度计，用量为 0.05% (质量)至 0.5o (质量)。
• Transmission belt
  申请人：MITSUBOSHI BELTING LTD.

  公开号：US10641355B2

  公开（公告）日：2020-05-05

  The present invention relates to a transmission belt containing a core wire extending in a lengthwise direction of the belt, an adhesive rubber layer in contact with at least a part of the core wire, a back surface rubber layer formed on one surface of the adhesive rubber layer, and an inner surface rubber layer formed on the other surface of the adhesive rubber layer and engaging or in contact with a pulley, in which the adhesive rubber layer is formed by a vulcanized rubber composition containing a rubber component, a fatty acid amide and a silica.

  本发明涉及一种传动带，包含沿传动带长度方向延伸的芯线、与芯线至少一部分接触的粘合橡胶层、形成于粘合橡胶层一个表面的背面橡胶层以及形成于粘合橡胶层另一个表面并与滑轮啮合或接触的内面橡胶层，其中粘合橡胶层由硫化橡胶组合物形成，该组合物包含橡胶成分、脂肪酸酰胺和二氧化硅。
• Evaluation of endogenous fatty acid amides and their synthetic analogues as potential anti-inflammatory leads
  作者：Hung The Dang、Gyeoung Jin Kang、Eun Sook Yoo、Jongki Hong、Jae Sue Choi、Hyung Sik Kim、Hae Young Chung、Jee H. Jung

  DOI：10.1016/j.bmc.2010.12.046

  日期：2011.2

  A series of endogenous fatty acid amides and their analogues (1-78) were prepared, and their inhibitory effects on pro-inflammatory mediators (NO, IL-1 beta, IL-6, and TNF-alpha) in LPS-activated RAW264.7 cells were evaluated. Their inhibitory activity on the pro-inflammatory chemokine MDC in IFN-gamma-activated HaCaT cells was also examined. The results showed that the activity is strongly dependent on the nature of the fatty acid part of the molecules. As expected, the amides derived from enone fatty acids showed significant activity and were more active than those derived from other types of fatty acids. A variation of the amine headgroup also altered bioactivity profile remarkably, possibly by modulating cell permeability. Regarding the amine part of the molecules, N-acyl dopamines exhibited the most potent activity (IC50 similar to 2 mu M). This is the first report of the inhibitory activity of endogenous fatty acid amides and their analogues on the production of nitric oxide, cytokines (IL-1 beta, IL-6, and TNF-alpha) and the chemokine MDC. This study suggests that the enone fatty acid-derived amides (such as N-acyl ethanolamines and N-acyl amino acids) and N-acyl dopamines may be potential anti-inflammatory leads. (C) 2010 Elsevier Ltd. All rights reserved.