(2,4-二氯苯氧基)乙酸丁氧基聚丙烯二醇酯 | 1928-45-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (2,4-二氯苯氧基)乙酸丁氧基聚丙烯二醇酯
• 英文名称: Acetic acid, (2,4-dichlorophenoxy)-, 3-butoxypropyl ester
• 英文别名: 3-butoxypropyl 2-(2,4-dichlorophenoxy)acetate
• CAS: 1928-45-6
• 化学式: C₁₅H₂₀Cl₂O₄
• 分子量: 335.2
• InChiKey: KZWPFFFDRDASOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  21
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

ADMET

代谢

植物将2,4-D酯水解成2,4-D，后者是活性除草剂。进一步的代谢通过三种机制发生，即侧链降解、芳香环羟基化和与植物成分的共轭作用。

Plants hydrolyze 2,4-D esters to 2,4-D, which is the active herbicide. ... Further metabolism ... occurs through three mechanisms, namely, side chain degradation, hydroxylation of the aromatic ring, and conjugation with plant constituents.

来源:Hazardous Substances Data Bank (HSDB)

代谢

草甘膦酸酯、腈、胺（以及当然的盐类）的除草活性与母酸相似，如果不是完全相同的话。这显然是由于植物和土壤微生物中存在的水解酶，这些酶将这些衍生物转化为母酸。/2,4-D 酯/

HERBICIDAL ACTIVITY OF ESTERS, NITRILES, AMINES (&, OF COURSE, SALTS) APPEARS SIMILAR IF NOT IDENTICAL TO PARENT ACID. THIS IS APPARENTLY DUE TO PRESENCE OF HYDROLYTIC ENZYMES IN PLANTS & IN SOIL MICROORGANISMS THAT CONVERT THESE DERIVATIVES TO PARENT ACID. /2,4-D ESTER/

来源:Hazardous Substances Data Bank (HSDB)

代谢

2,4-D 酯类在动物体内被水解。在大鼠口服给药后，苯氧基酸主要以原形从尿液中排出，尽管有一小部分与氨基酸（甘氨酸和牛磺酸）和葡萄糖酸结合。

2,4-D ESTERS ARE HYDROLYZED IN ANIMALS. THE PHENOXY ACIDS ARE EXCRETED PREDOMINANTLY AS SUCH IN THE URINE OF RATS AFTER THEIR ORAL ADMIN, ALTHOUGH MINOR PORTION IS CONJUGATED WITH AMINO ACIDS GLYCINE & TAURINE & WITH GLUCURONIC ACID. /2,4-D AND ESTERS/

来源:Hazardous Substances Data Bank (HSDB)

代谢

氯苯氧酸衍生物通过参与肝脏微粒体混合功能氧化酶系统进行代谢。因此，向大鼠给药2,4-D胺盐及其丁酯...会诱导酶系统（氨基吡啶脱甲基酶...和对氨基苯酚加氧酶）...尽管诱导程度远低于苯巴比妥的。长期给药2,4-D胺盐（0.1 LD50）显示出累积效应，这种效应通过临床和生化变化反映出来。刺激混合功能氧化酶系统可能是减少这类化合物毒理效应的方法之一。

Chlorophenoxy acid derivatives are metabolized via participation of the hepatic microsomal mixed-function oxidase system. Thus, administration of 2,4-D amine salt and its butyl ester ... to rats induced the enzyme system (aminopyrine demethylase ... and aniline hydroxylase) ... although the degree of induction was substantially lower than that from phenobarbital. Prolonged administration of 2,4-D amine salt (0.1 LD50) showed cumulative effects reflected by both clinical and biochemical changes. Stimulation of mixed-function oxidase system may be one of the methods for reducing toxicological effects of this type of compounds.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

A4；不能分类为人类致癌物。/2,4-D/

A4; Not classifiable as a human carcinogen. /2,4-D/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

致癌性分类：1）人类证据：有限；对人类致癌风险的总体评估为2B组：该物质可能对人类致癌。/SRP：早期文献表明这些化合物具有致癌性。后来发现这是由于污染，包括二噁英。/ /氯苯氧基除草剂；来自表格/

Classification of carcinogenicity: 1) evidence in humans: limited; overall summary evaluation of carcinogenic risk to humans is Group 2B: The agent is possibly carcinogenic to humans. /SRP: The older literature indicated that these compounds were carcinogenic. It was discovered that this was due to contamination, including dioxin./ /Chlorophenoxy herbicides; From table/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 副作用

职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒病例。

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

基本治疗：建立专利气道。如有必要，进行吸痰。观察呼吸不足的迹象，如有必要，协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，如有必要，进行治疗……。监测休克，如有必要，进行治疗……。预见并治疗癫痫发作……。对于眼睛污染，立即用水冲洗眼睛。在转运过程中，用生理盐水连续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能吞咽、有强烈的干呕反射且不流口水，则用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释。给予活性炭……。监测体温，如有必要，进行治疗。/氯苯氧基除草剂及相关化合物/

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Monitor body temperature and treat if necessary. /Chlorophenoxy herbicides and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

高级治疗：对于无意识的病人，考虑进行口咽或鼻咽气管插管以控制气道。使用气囊面罩装置的正压通气技术可能有益。监测心率和必要时治疗心律失常。开始静脉输注乳酸林格氏液/生理盐水： "保持通路开放"，最低流速/。调整以维持足够的尿流量。注意液体过载的迹象。监测心率和必要时治疗心律失常。考虑使用药物治疗肺水肿。对于伴有低血容量迹象的低血压，谨慎给予液体。如果没有低血容量的迹象而出现低血压，考虑使用血管加压药。使用地西泮治疗癫痫。使用丙美卡因氢氯化物协助眼部冲洗。/氯苯氧草剂及相关化合物/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with lactated Ringer's /SRP: "To keep open", minimal flow rate/. Titrate to maintain adequate urine flow. Watch for signs of fluid overload. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if hypotensive without signs of hypovolemia ... . Treat seizures with diazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Chlorophenoxy herbicides and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

叶子最容易吸收非极性（酯）形式。... 2,4-D的酯类倾向于抵抗从植物上被洗掉，并且能被植物迅速转化为酸。... 叶面吸收后，2,4-D在韧皮部内转移，可能是随着食物物质一起移动。根吸收后，它可能沿着蒸腾流向上移动。转移过程受到植物生长状况的影响。除草剂主要积累在茎和根的嫩梢区域。/2,4-D及其酯类/

Leaves absorb nonpolar (ester) forms most readily. ... The esters of 2,4-D tend to resist washing from plants and are rapidly converted to the acid by the plants. ... Following foliar absorption, 2,4-D translocates within the phloem, probably moving with food material. Following root absorption, it may move upward in the transpiration stream. Translocation is influenced by the growth status of the plant. Accumulation of the herbicide occurs principally at the meristematic regions of shoots and roots. /2,4-D and its esters/

来源:Hazardous Substances Data Bank (HSDB)

文献信息

• HERBICIDAL COMPOSITIONS
  申请人：Bayer Aktiengesellschaft

  公开号：US20220053762A1

  公开（公告）日：2022-02-24

  The present invention provides compositions comprising herbicidally active compounds (A) and (B), where (A) represents one or more compounds of the general formula (I) or agrochemically compatible salts thereof [component (A)], and (B) represents one or more herbicides [component (B)]. The application further relates to a method and to the use of the herbicidal composition according to the invention for controlling harmful plants or for regulating growth.

  本发明提供了包含除草活性化合物（A）和（B）的组合物，其中（A）代表通式（I）的一个或多个化合物或其农药兼容盐[组分（A）]，（B）代表一个或多个除草剂[组分（B）]。该申请进一步涉及一种方法和利用本发明的除草组合物来控制有害植物或调节生长。
• USE OF CERTAIN HERBICIDE COMBINATIONS BASED ON IODOSULFURON IN TEFF PLANTS
  申请人：Bayer CropScience Aktiengesellschaft

  公开号：EP3222143A1

  公开（公告）日：2017-09-27

  The present invention primarily relates to the use of specific herbicide combinations based on iodosulfuron or of a composition comprising said specific herbicide combinations for controlling harmful plants in teff (Eragrostis tef) plants. The present invention also relates to the use of specific herbicide combinations based on iodosulfuron or of a composition comprising said specific herbicide combinations as plant growth regulators for teff (Eragrostis tef) plants. Furthermore, the present invention relates to a corresponding method ofcontrolling harmful plants in teff (Eragrostis tef) plants and to a corresponding method of regulating plant growth of teff (Eragrostis tef) plants.

  本发明主要涉及基于碘磺隆的特异性除草剂组合物或包含所述特异性除草剂组合物的组合物在控制茶树（Eragrostis tef）植物中有害植物方面的用途。本发明还涉及以碘磺隆为基础的特定除草剂组合物或包含所述特定除草剂组合物的组合物作为植物生长调节剂用于柚木（Eragrostis tef）植物的用途。此外，本发明还涉及控制柚木（Eragrostis tef）植物中有害植物的相应方法，以及调节柚木（Eragrostis tef）植物生长的相应方法。
• Use of certain herbicide combinations based on iodosulfuron in teff plants
  申请人：BAYER CROPSCIENCE AKTIENGESELLSCHAFT

  公开号：US10264790B2

  公开（公告）日：2019-04-23

  The present invention primarily relates to the use of specific herbicide combinations based on iodosulfuron or of a composition comprising said specific herbicide combinations for controlling harmful plants in teff (Eragrostis tef) plants. The present invention also relates to the use of specific herbicide combinations based on iodosulfuron or of a composition comprising said specific herbicide combinations as plant growth regulators for teff (Eragrostis tef) plants. Furthermore, the present invention relates to a corresponding method of controlling harmful plants in teff (Eragrostis tef) plants and to a corresponding method of regulating plant growth of teff (Eragrostis tef) plants.

  本发明主要涉及基于碘磺隆的特异性除草剂组合物或包含所述特异性除草剂组合物的组合物在控制茶树（Eragrostis tef）植物中有害植物方面的用途。本发明还涉及以碘磺隆为基础的特定除草剂组合物或包含所述特定除草剂组合物的组合物作为植物生长调节剂用于柚木（Eragrostis tef）植物的用途。此外，本发明还涉及控制柚木（Eragrostis tef）植物中有害植物的相应方法，以及调节柚木（Eragrostis tef）植物生长的相应方法。
• HERBIZIDE ZUSAMMENSETZUNGEN
  申请人：Bayer Aktiengesellschaft

  公开号：EP3890488A1

  公开（公告）日：2021-10-13
• Methods and compositions for increasing the efficacy of biologically-active ingredients
  申请人：Windsor Brian J.

  公开号：US20060276339A1

  公开（公告）日：2006-12-07

  The invention provides methods and compositions for modulating the sensitivity of cells to cytotoxic compounds and other active agents. In accordance with the invention, compositions are provided comprising combinations of ectophosphatase inhibitors and active agents. Active agents include antibiotics, fungicides, herbicides, insecticides, chemotherapeutic agents, and plant growth regulators. By increasing the efficacy of active agents, the invention allows use of compositions with lowered concentrations of active ingredients.