(2-{4-[(4-氟苯基)(苯基)甲基]哌嗪-1-基}乙氧基)乙酸 | 83881-57-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (2-{4-[(4-氟苯基)(苯基)甲基]哌嗪-1-基}乙氧基)乙酸
• 中文别名: (2-(4-((4-氟苯基)苯基甲基)-1-哌嗪基)乙氧基)乙酸水合物
• 英文名称: Acetic acid, (2-(4-((4-fluorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, hydrate
• 英文别名: 2-[2-[4-[(4-fluorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid
• CAS: 83881-57-6
• 化学式: C₂₁H₂₅FN₂O₃
• 分子量: 372.4
• InChiKey: ACMKLMXMTWDEHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  53
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease
  申请人：Robinson B. Cynthia

  公开号：US20050026890A1

  公开（公告）日：2005-02-03

  A pharmaceutical or veterinary composition, comprises a first active agent selected from a dehydroepiandrosterone and/or dehydroepiandrosterone-sulfate, or a salt thereof, and a second active agent comprising an antihistamine for the treatment of asthma, chronic obstructive pulmonary disease, or any other respiratory disease. The composition is provided in various formulations and in the form of a kit. The products of this patent are applied to the prophylaxis and treatment of asthma, chronic obstructive pulmonary disease, or any other respiratory disease.

  一种制药或兽医组合物，包括第一活性剂，所述第一活性剂选自去氢表雄酮和/或去氢表雄酮硫酸盐，或其盐，并且第二活性剂包括一种抗组胺药物，用于治疗哮喘、慢性阻塞性肺疾病或任何其他呼吸系统疾病。该组合物以各种制剂和套装形式提供。本专利的产品应用于哮喘、慢性阻塞性肺疾病或任何其他呼吸系统疾病的预防和治疗。
• Pharmaceutical compositions for the treatment of rhinitis
  申请人：——

  公开号：US20010020023A1

  公开（公告）日：2001-09-06

  A pharmaceutical composition comprising a therapeutically effective amount of a mixture consisting essentially of (i) pseudoephedrine, an individual optical isomer or a pharmaceutically acceptable salt thereof, and (ii) at least one compound selected from 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acid or amide derivatives, an individual optical isomer or a pharmaceutically acceptable salt thereof.

  一种药物组合物，含有治疗有效量的混合物，其主要成分为 (i) 伪麻黄碱、其单个光学异构体或药学上可接受的盐，和 (ii) 至少一种选自 2-[4-(二苯基甲基)-1-哌嗪基]-乙酸或酰胺衍生物的化合物、其单个光学异构体或药学上可接受的盐。
• Nouveaux acides 2-(4-(diphénylméthyl)-1-pipérazinyl)-acétiques et leurs amides, leurs procédés de préparation et compositions thérapeutiques
  申请人：U C B, S.A.

  公开号：EP0058146B1

  公开（公告）日：1984-06-27
• NAPROXEN/CETIRIZINE COMPOSITIONS AND METHODS FOR TREATING RESPIRATORY DISORDERS
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP1014983A1

  公开（公告）日：2000-07-05
• Diarylmethylpiperazines As Prophylactic Or Therapeutic Agents For Viral Myocarditis
  申请人：Matsumori Akira

  公开号：US20070281947A1

  公开（公告）日：2007-12-06

  To provide a prophylactic or therapeutic agent for viral myocarditis and viral myocarditis-related viral diseases by preventing or treating the occurrence of cell damage in various organs regardless of the type of virus. A prophylactic or therapeutic agent for viral myocarditis and via myocarditis-related via diseases is provided that comprises as an active ingredient 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acid, amide derivative, individual optical isomer or pharmaceutically acceptable salt thereof.