尼莫地平杂质6 | 116799-92-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 尼莫地平杂质6
• 英文名称: 2-Methoxyethyl 1-Methylethyl 1,4-Dihydro-2,6-dimethyl-4-(3-hydroxylaminophenyl)-3,5-pyridinedicarboxylate
• 英文别名: 3-O-(2-methoxyethyl) 5-O-propan-2-yl 4-[3-(hydroxyamino)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• CAS: 116799-92-9
• 化学式: C₂₁H₂₈N₂O₆
• 分子量: 404.463
• InChiKey: PEVXZCWDMJJTCB-UHFFFAOYSA-N

物化性质

• 沸点：
  547.4±60.0 °C(Predicted)
• 密度：
  1.212±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  29
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  106
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  尼莫地平杂质6 生成 2-Methoxyethyl 1-Methylethyl 1,4-Dihydro-2,6-dimethyl-4-{3-[(Z)-N-(3-nitrophenylmethylene)-N-oxo-λ5-azanyl]phenyl}-3,5-pyridinedicarboxylate
  参考文献：
  名称：

  JOHNSON, CARL R.;TAYLOR, JOHN D.;HONN, KENNETH V.;CHENG, SOAN

  摘要：

  DOI：
• 作为产物：
  描述：

  尼莫地平 生成 尼莫地平杂质6
  参考文献：
  名称：

  JOHNSON, CARL R.;TAYLOR, JOHN D.;HONN, KENNETH V.;CHENG, SOAN

  摘要：

  DOI：

文献信息

• 4-(nitrone aryl) dihydropyridines
  申请人：Radiation Oncology Center Research and Development Corporation

  公开号：US04758669A1

  公开（公告）日：1988-07-19

  Novel nitrone substituted 4-aryl dihydropyridines of the formula: ##STR1## are described along with a process for their preparation. The compounds exhibit calcium channel blocker and antimetastatic acitivity.

  描述了一种新型的氮醚取代的4-芳基二氢吡啶，其化学式为：##STR1##，并附带了它们的制备过程。这些化合物表现出钙通道阻滞剂和抗转移活性。
• Intramolecular Electron Transfer in the Photochemistry of Some Nitrophenyldihydropyridines
  作者：Elisa Fasani、Maurizio Fagnoni、Daniele Dondi、Angelo Albini

  DOI：10.1021/jo052463z

  日期：2006.3.1

  The lowest singlet is localized on the dihydropyridine moiety (1PyH2-Ph) and emits a blue fluorescence (with close to unitary efficiency in glass at 77 K). In 3-nitrophenyl derivatives (PyH2-PhNO2, some of which are photolabile drugs) the fluorescence is completely quenched. Reasonably, this is due to intramolecular electron transfer between the close-lying donor and acceptor moieties to give the charge-separated

  4-苯基-1,4-二氢吡啶-3,5-二羧酸酯包含两个被sp 3碳隔开的π发色团。最低的单峰位于二氢吡啶部分（1 PyH 2 -Ph）上，并发出蓝色荧光（在77 K的玻璃中具有接近统一的效率）。在3-硝基苯基衍生物（PyH 2 -PhNO 2，其中一些是对光不稳定的药物）中，荧光被完全淬灭。合理地，这是由于在紧密的供体和受体部分之间进行分子内电子转移，从而产生了电荷分离的物质（PyH 2 • + -PhNO 2 • -）。在77 K的EPA玻璃中，背电子转移产生二氢吡啶定位的三重态（3 PyH 2 -PhNO 2），发出黄色磷光。在溶液中，从上二氢吡啶部分发起rearomatization，最后得到PY-PHNO的自由基阳离子脱质子化2具有低量子产率（5×10 - 4〜5×10 - 3，通过在254 nm处照射而增加至0.013，其中硝基苯基发色团的直接激发起作用）。在三乙胺的存在下，反应变
• ARTICLES OF MANUFACTURE AND METHODS RELATED TO TOXICITY ASSOCIATED WITH CELL THERAPY
  申请人：Juno Therapeutics, Inc.

  公开号：US20200110077A1

  公开（公告）日：2020-04-09

  Provided are methods and articles of manufacture for use with cell therapy for the treatment of diseases or conditions, e.g., cancer, including for predicting and treating a toxicity. In some embodiments, the toxicity is a neurotoxicity or cytokine release syndrome (CRS), such as a severe neurotoxicity or a severe CRS. The methods generally involve detecting a marker by assaying a biological sample from a subject that is a candidate for treatment, optionally with a cell therapy, to determine if the subject is at risk for developing the toxicity, such as neurotoxicity or CRS or severe neurotoxicity or severe CRS. In some embodiments, the methods and articles of manufacture further includes a regent for assaying the biological sample and instructions for determining the percentage or number of cells positive for the marker in the biological sample.
• ARTICLES OF MANUFACTURE AND METHODS FOR TREATMENT USING ADOPTIVE CELL THERAPY
  申请人：Juno Therapeutics, Inc.

  公开号：US20200147136A1

  公开（公告）日：2020-05-14

  Provided are adoptive cell therapy methods involving the administration of doses of cells for treating disease and conditions, including certain B cell malignancies. The cells generally express recombinant receptors such as chimeric antigen receptors (CARs). In some embodiments, the methods are for treating subjects with non-Hodgkin lymphoma (NHL). In some embodiments, the methods are for treating subjects with relapsed or refractory NHL. Also provided are articles of manufacture and prophylactic treatments in connection with adoptive therapy methods.
• US4758669A
  申请人：——

  公开号：US4758669A

  公开（公告）日：1988-07-19