(22S,25R)-5alpha-茄甾-3beta-醇 | 11004-30-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: (22S,25R)-5alpha-茄甾-3beta-醇
• 英文名称: 22(S),25(R)-demissidine
• 英文别名: 5α,22β25αH-solanidan-3β-ol；(22S,25R)-5alpha-Solanidan-3beta-ol；(1S,2R,5S,7S,10S,11S,14S,15R,16S,17S,20R,23S)-10,14,16,20-tetramethyl-22-azahexacyclo[12.10.0.02,11.05,10.015,23.017,22]tetracosan-7-ol
• CAS: 11004-30-1
• 化学式: C₂₇H₄₅NO
• 分子量: 399.66
• InChiKey: JALVTHFTYRPDMB-IKSKCRHHSA-N

物化性质

• 熔点：
  168-170 °C
• 沸点：
  523.27°C (rough estimate)
• 密度：
  0.9679 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  29
• 可旋转键数：
  0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (25R)-22,26-epiminocholesta-5,22(N)-diene-3β,16β-diol diacetate 在 chromium(VI) oxide 、 溶剂黄146 、 丙酮 、 铂 作用下， 生成 (22S,25R)-5alpha-茄甾-3beta-醇
  参考文献：
  名称：

  Some Reactions of Solasodine^*1

  摘要：

  DOI：

  10.1021/jo01362a047

文献信息

• Schreiber; Adam, Justus Liebigs Annalen der Chemie, 1963, vol. 666, p. 176,184
  作者：Schreiber、Adam

  DOI：——

  日期：——
• Chemistry of the Spiroaminoketal Side Chain of Solasodine and Tomatidine. V.¹ The Synthesis of the Isomeric Solanidanones
  作者：YASHIO SATO、NOBUO IKEKAWA

  DOI：10.1021/jo01065a062

  日期：1961.6
• HERPES VIRUS-BASED COMPOSITIONS AND METHODS OF USE IN THE PRENATAL AND PERINATAL PERIODS
  申请人：THE UNIVERSITY OF ROCHESTER

  公开号：EP1903873A2

  公开（公告）日：2008-04-02
• Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby
  申请人：West D. Michael

  公开号：US20080070303A1

  公开（公告）日：2008-03-20

  This invention generally relates to methods to differentiate pluripotent stem cells, such as embryonic stem, embryonic germ, or embryo-derived cells, to obtain subpopulations of cells from heterogeneous mixtures of cells wherein the subpopulation of cells possess reduced differentiation potential compared to the original pluripotent stem cells and where the subpopulation is capable of being propagated.
• Herpes Virus-Based Compositions and Methods of Use in the Prenatal and Perinatal Periods
  申请人：Federoff Howard J.

  公开号：US20080226601A1

  公开（公告）日：2008-09-18

  Disclosed are compositions and methods for reducing the severity of a birth defect in a mammal by exposing the mammal (e.g., in utero) to a herpes virus amplicon particle comprising a cis element-flanked transgene and a sequence encoding a transposase. Upon expression, the transposase inserts the transgene into the genome of a cell (e.g., a neuron) within the mammal and the transgene expresses a polypeptide or RNA that compensates for a protein or gene defect that is causally associated with the birth defect.