(23S)-25-去(1-甲基丙基)-22,23-二氢-23-羟基-25-异丙基阿维菌素A1a | 65195-54-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 中文名称: (23S)-25-去(1-甲基丙基)-22,23-二氢-23-羟基-25-异丙基阿维菌素A1a
• 英文名称: Avermectin A2b
• 英文别名: (1R,4S,4'S,5'S,6R,6'R,8R,10E,12S,13S,14E,16E,20R,21R,24S)-4',24-dihydroxy-12-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-21-methoxy-5',11,13,22-tetramethyl-6'-propan-2-ylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one
• CAS: 65195-54-2
• 化学式: C₄₈H₇₄O₁₅
• 分子量: 891.1
• InChiKey: QUTFLJHOCPQPEW-WUSILSRKSA-N

物化性质

• 沸点：
  945.9±65.0 °C(Predicted)
• 密度：
  1.24±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  63
• 可旋转键数：
  8
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  179
• 氢给体数：
  3
• 氢受体数：
  15

文献信息

• DIMERIC AVERMECTIN AND MILBEMYCIN DERIVATIVES
  申请人：Meng Charles Q.

  公开号：US20100144859A1

  公开（公告）日：2010-06-10

  This invention provides for novel antiparasitic and pesticidal derivatives of avermectin and milbemycin compounds in which two avermectin or milbemycin members are linked together by a chemical linker. The resulting compounds may be used in veterinary compositions which are used in treating, controlling and preventing of endo- and ectoparasite infections and infestations in animals or for combating pests in plants or plant propagation material.

  这项发明提供了一种新颖的阿维菌素和米氏菌素衍生物，其中两个阿维菌素或米氏菌素成员通过化学连接剂连接在一起。所得的化合物可用于兽药组合物中，用于治疗、控制和预防动物体内和体外寄生虫感染及寄生虫侵染，或用于对抗植物或植物繁殖材料中的害虫。
• AVERMECTIN DERIVATIVES
  申请人：Jeschke Peter

  公开号：US20100234312A1

  公开（公告）日：2010-09-16

  Novel avermectin derivatives of the formula (I) in which —C 22 R 1 -A-C 23 R 2 , R 3 , R 4 and R 5 have the meanings given in the description, processes for preparing these compounds and their use for controlling animal pests, and also novel intermediates and their preparation

  本发明涉及一种新的阿维菌素衍生物，其化学式为（I），其中—C22R1-A-C23R2，R3，R4和R5的含义如描述所述，本发明还涉及制备这些化合物的方法、用于控制动物害虫的方法，以及新的中间体及其制备方法。
• Synergistic Combination of Glutamate-and Gaba-Gated Chloride Agonist Pesticide and at Least One Vitamin E, Niacin, or Derivatives Thereof
  申请人：Pedersen Morten

  公开号：US20090111759A1

  公开（公告）日：2009-04-30

  Presented are pesticidal compositions comprising at least one pesticide selected among Glutamate- or GABA-gated chloride channel agonist pesticides and at least one synergist which is selected among Vitamin E, Niacin and derivatives thereof. The combinations of these compounds show a synergistic effect allowing a composition to be prepared comprising a lesser amount of pesticide, while still controlling the harmful pests.

  提供的是杀虫组合物，包括至少一种从谷氨酸或GABA门控氯离子通道激动剂杀虫剂中选择的杀虫剂，以及至少一种从维生素E、烟酸及其衍生物中选择的协同剂。这些化合物的组合表现出协同效应，允许制备含较少杀虫剂的组合物，同时仍然控制有害的害虫。
• Strain of streptomyces for producing antiparasitic compounds and processes therewith
  申请人：ELI LILLY AND COMPANY

  公开号：EP0600656A2

  公开（公告）日：1994-06-08

  A new microorganism, Streptomyces avermitilis subspecies niger NRRL 21005, and processes using the microorganism for producing known avermectins and ivermectin are provided.

  本研究提供了一种新的微生物--Streptomyces avermitilis subspecies niger NRRL 21005，以及使用该微生物生产已知阿维菌素和伊维菌素的工艺。
• Synergistic combination of glutamate- and GABA-gated chloride agonist pesticide and at least one of Vitamin E or Niacin
  申请人：Cheminova A/S

  公开号：EP1849363A1

  公开（公告）日：2007-10-31

  Presented are pesticidal compositions comprising at least one compound A selected among Glutamate- or GABA-gated chloride channel agonist pesticides and at least one compound B which is selected among Vitamin E and Niacin. The combinations of these compounds show a synergistic effect in the control of harmful pests.

  所介绍的杀虫组合物包含至少一种选自谷氨酸或 GABA 门控氯离子通道激动剂杀虫剂的化合物 A 和至少一种选自维生素 E 和烟酸的化合物 B。这些化合物的组合在控制有害害虫方面显示出协同效应。