(2-Ethylphenyl)carbamic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-Ethylphenyl)carbamic acid
• 化学式: C₉H₁₁NO₂
• 分子量: 165.19
• InChiKey: VZVANBCKRMEFMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Organic compounds
  申请人：Bold Guido

  公开号：US20050222171A1

  公开（公告）日：2005-10-06

  The invention relates to the use of pyrazolo[1,5a]pyrimidin-7-yl amine compounds and salts thereof in the treatment of kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds, and a process for the preparation of the novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds.

  该发明涉及在激酶依赖性疾病的治疗中使用吡唑并[1,5a]嘧啶-7-基胺化合物及其盐，并用于制备用于治疗该类疾病的药物制剂，新型吡唑并[1,5a]嘧啶-7-基胺化合物，以及制备新型吡唑并[1,5a]嘧啶-7-基胺化合物的方法。
• Use of Pyrazolo(1,5A)Pyrimidin-7-YL Amine Derivatives in the Treatment of Neurological Disorders
  申请人：Sivasankaran Rajeev

  公开号：US20090069315A1

  公开（公告）日：2009-03-12

  The invention relates to methods of using the compounds of the invention, including pyrazolo[1,5a]pyrimidin-7-yl amine compounds and salts thereof, as well as pharmaceutical compositions comprising the same, in the treatment of Eph receptor-related (e.g., neurological) injuries and disorders. The invention also relates to modulating the activity of an Eph receptor in a cell, stimulating neural regeneration, and reversing neuronal degeneration, by administering a compound of the invention to a cell or subject in an effective amount.

  该发明涉及使用该发明的化合物的方法，包括吡唑并[1,5a]嘧啶-7-基胺化合物及其盐，以及包含相同的药物组合物，在治疗Eph受体相关（例如神经）损伤和疾病方面的用途。该发明还涉及通过向细胞或受体中有效量的给予该发明的化合物，来调节Eph受体的活性，刺激神经再生，并逆转神经细胞的退化。
• [EN] N-(2-FLUORO-2-PHENETHYL)CARBOXAMIDES AS NEMATICIDES AND ENDOPARASITICIDES<br/>[FR] N-(2-FLUORO-2-PHÉNÉTHYL)CARBOXAMIDES EN TANT QUE NÉMATOCIDES ET ENDOPARASITICIDES
  申请人：BAYER CROPSCIENCE AG

  公开号：WO2014177582A1

  公开（公告）日：2014-11-06

  The present invention relates to N-(2-halogen-2-phenethyl)carboxamides, a process for producing such compounds, their use for the control of nematodes in agricultures and their use as anthelmintics against endoparasites in animals or humans, compositions containing such compounds and methods for the control of nematodes and helminths.

  本发明涉及N-(2-卤代-2-苯乙基)羧酰胺，一种生产这种化合物的方法，它们在农业中用于控制线虫以及作为驱虫剂对动物或人体内寄生虫的用途，含有这种化合物的组合物以及用于控制线虫和蠕虫的方法。
• N-(2-FLUORO-2-PHENETHYL)CARBOXAMIDES AS NEMATICIDES AND ENDOPARASITICIDES
  申请人：BAYER CROPSCIENCE AKTIENGESSELLSCHAFT

  公开号：US20160075637A1

  公开（公告）日：2016-03-17

  The present invention relates to N-(2-halogen-2-phenethyl)carboxamides, a process for producing such compounds, their use for the control of nematodes in agricultures and their use as anthelmintics against endoparasites in animals or humans, compositions containing such compounds and methods for the control of nematodes and helminths.

  本发明涉及N-(2-卤代-2-苯乙基)羧酰胺，制备这些化合物的过程，它们在农业中控制线虫的用途以及它们作为驱虫剂用于动物或人类内寄生虫，包含这些化合物的组合物和控制线虫和蠕虫的方法。
• Preparation of diphenylmethane dicarbamates and polymethylene polyphenyl carbamates with Lewis acid catalysts intercalated in graphite
  申请人：ATLANTIC RICHFIELD COMPANY

  公开号：EP0014482A1

  公开（公告）日：1980-08-20

  Diphenylmethane dicarbamates and polymethylene polyphenyl carbamate homologs and derivatives of these compounds are produced by the condensation of N-aryl carbamic acid esters, such as ethylphenylcarbamate, with a carbonyl compound selected from formaldehyde, para-formaldehyde or trioxane at a temperature of between about ambient and 170°C. in the presence of a Lewis acid intercalated in graphite and optionally in the presence of an inert solvent.

  二苯基甲烷二氨基甲酸酯和多亚甲基多苯基氨基甲酸酯的同系物及其衍生物是通过 N-芳基氨基甲酸酯（如乙基苯基氨基甲酸酯）与选自甲醛、对位甲醛或三氧杂环己烷的羰基化合物在约常温至 170°C 的温度下，在石墨中夹杂的路易斯酸的存在下，并可选在惰性溶剂的存在下缩合而制得。