(2R,3E,12bS)-3-亚乙基-2-(9H-吡啶并[3,4-b]吲哚-1-基甲基)-2,4,6,7,12,12b-六氢-1H-吲哚并[3,2-H]喹嗪 | 36150-14-8

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 哈马拉生物碱
• 中文名称: (2R,3E,12bS)-3-亚乙基-2-(9H-吡啶并[3,4-b]吲哚-1-基甲基)-2,4,6,7,12,12b-六氢-1H-吲哚并[3,2-H]喹嗪
• 英文名称: Usambarensine
• 英文别名: (2R,3E,12bS)-3-ethylidene-2-(9H-pyrido[3,4-b]indol-1-ylmethyl)-2,4,6,7,12,12b-hexahydro-1H-indolo[2,3-a]quinolizine
• CAS: 36150-14-8
• 化学式: C₂₉H₂₈N₄
• 分子量: 432.6
• InChiKey: VUMZOPMHFVDIMF-NLLHOBBWSA-N

物化性质

• 沸点：
  685.0±55.0 °C(Predicted)
• 密度：
  1.31±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  33
• 可旋转键数：
  2
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  47.7
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• MANUFACTURE, METHOD AND USE OF ACTIVE SUBSTANCE-RELEASING MEDICAL PRODUCTS FOR PERMANENTLY KEEPING BLOOD VESSELS OPEN
  申请人：Hoffmann Erika

  公开号：US20100063585A1

  公开（公告）日：2010-03-11

  The invention relates to stents and catheter balloons having optimized coatings for eluting rapamycin as well as methods for manufacturing these coatings.

  本发明涉及具有优化涂层以释放雷帕霉素的支架和导管球囊，以及制造这些涂层的方法。
• MANUFACTURE, METHOD AND USE OF DRUG-ELUTING MEDICAL DEVICES FOR PERMANENTLY KEEPING BLOOD VESSELS OPEN
  申请人：Hoffmann Erika

  公开号：US20130005758A1

  公开（公告）日：2013-01-03

  The invention relates to stents and catheter balloons having optimized coatings for eluting rapamycin as well as methods for manufacturing these coatings.

  本发明涉及具有经过优化的涂层以释放雷帕霉素的支架和导管球囊，以及制造这些涂层的方法。
• BALLOON CATHETER WITH POLYMERIC BALLOON HAVING A SURFACE MODIFIED BY A PHOTOACTIVATION REACTION AND METHOD OF MAKING
  申请人：D'Onofrio Simone

  公开号：US20140378897A1

  公开（公告）日：2014-12-25

  A balloon catheter, in particular a balloon catheter for angioplasty, the balloon having an inner or outer surface modified by means of a photoactivation reaction.

  一个气球导管，特别是用于血管成形术的气球导管，该气球通过光活化反应改性内部或外部表面。
• Expandable medical device for the treatment and prevention of cardiovascular diseases
  申请人：Perelson, Ophir

  公开号：EP1913962A1

  公开（公告）日：2008-04-23

  The invention relates to expandable medical devices such as stents, bioresorbable stents or catheter balloons with or without crimped stents comprising the pharmaceutically active agent gemcitabine as pure compound or incorporated into a drug release matrix optionally in combination with other drugs for the treatment of cardiovascular diseases such as arteriosclerosis, atherosclerosis, stenosis or restenosis and methods for the manufacture of these expandable medical devices.

  本发明涉及用于治疗动脉硬化、动脉粥样硬化、血管狭窄或再狭窄等心血管疾病的可膨胀医疗器械，如支架、生物可吸收支架或带或不带卷边支架的导管球囊，其中包含纯化合物形式的药物活性剂吉西他滨，或将其掺入药物释放基质（可选择与其他药物组合使用），以及制造这些可膨胀医疗器械的方法。
• Drug releasing coatings for medical devices
  申请人：Lutonix, Inc.

  公开号：EP2092941A2

  公开（公告）日：2009-08-26

  The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and additive. The additive has a hydrophilic part and a hydrophobic part and the therapeutic agent is not enclosed in micelles or encapsulated in particles or controlled release carriers.

  本发明涉及一种向组织输送治疗剂的医疗器械。该医疗器械的外表面覆盖有一层。该层含有治疗剂和添加剂。添加剂有亲水部分和疏水部分，治疗剂不包裹在胶束中，也不封装在颗粒或控释载体中。