(6E)-4-amino-6-[[4-[4-[(2E)-2-(8-amino-1-oxo-5,7-disulfonaphthalen-2-ylidene)hydrazinyl]-3-methylphenyl]-2-methylphenyl]hydrazinylidene]-5-oxonaphthalene-1,3-disulfonic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (6E)-4-amino-6-[[4-[4-[(2E)-2-(8-amino-1-oxo-5,7-disulfonaphthalen-2-ylidene)hydrazinyl]-3-methylphenyl]-2-methylphenyl]hydrazinylidene]-5-oxonaphthalene-1,3-disulfonic acid
• 化学式: C₃₄H₂₈N₆O₁₄S₄
• 分子量: 872.9
• InChiKey: LIRUWPZKVZZTHC-DBMXBCQFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  58
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  386
• 氢给体数：
  8
• 氢受体数：
  20

文献信息

• COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES
  申请人：Johansen Lisa M.

  公开号：US20100009970A1

  公开（公告）日：2010-01-14

  The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E) and the agent or combination of agents includes sertraline, a sertraline analog, UK-416244, or a UK-416244 analog. Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.

  本发明涉及用于治疗病毒性疾病的组合物、方法和试剂盒。在某些实施方式中，病毒性疾病是由单链RNA病毒、黄病毒科病毒或肝病毒引起的。在特定实施方式中，病毒性疾病是病毒性肝炎（例如甲型肝炎、乙型肝炎、丙型肝炎、丁型肝炎、戊型肝炎），药剂或药剂组合包括舍曲林、舍曲林类似物、UK-416244或UK-416244类似物。还包括用于鉴定可用于治疗病毒性疾病的新化合物的筛选方法。
• Cell-penetrating compositions and methods using same
  申请人：Yale University

  公开号：US10550151B2

  公开（公告）日：2020-02-04

  An isolated transport peptide, which crosses the cell membrane of a cell and/or binds to a target cell is described. The transport peptide can be incorporated into a transport construct in which the transport peptide is linked to a cargo moiety to be delivered into a cell. Also described herein is a method of delivering a transport construct into and/or to a cell.

  本文描述了一种分离的转运肽，它能穿过细胞的细胞膜和/或与目标细胞结合。该转运肽可与转运构建物结合，其中转运肽与货物连接，以输送到细胞中。本文还描述了一种将转运构建物送入和/或送至细胞的方法。
• Inhibition of thymine DNA glycosylase in the treatment of cancer
  申请人：Institute for Cancer Research

  公开号：US11077121B2

  公开（公告）日：2021-08-03

  The invention provides compositions, kits, and methods for inducing growth arrest, differentiation, or senescence of cancer cells that express thymine DNA glycosylase, and treating the cancer accordingly. The methods comprise inhibiting expression or biologic activity of thymine DNA glycosylase in cancer cells. Inhibition of thymine DNA glycosylase in cancer cells may induce the cells to revert to a healthy, non-cancerous phenotype and/or may induce the cells to senesce. Cancer cells include melanoma, lung, prostate, pancreatic, ovarian, brain, colon, recto-sigmoid colon, and breast cancer cells.

  本发明提供了用于诱导表达胸腺嘧啶DNA糖基化酶的癌细胞生长停滞、分化或衰老，并对癌症进行相应治疗的组合物、试剂盒和方法。这些方法包括抑制胸腺嘧啶 DNA 糖基化酶在癌细胞中的表达或生物活性。抑制癌细胞中胸腺嘧啶DNA糖基化酶可诱导细胞恢复到健康的非癌表型和/或诱导细胞衰老。癌细胞包括黑色素瘤、肺癌、前列腺癌、胰腺癌、卵巢癌、脑癌、结肠癌、直肠乙状结肠癌和乳腺癌细胞。
• CLOSANTEL IN COMBINATION WITH TEMOZOLOMIDE FOR USE IN THE TREATMENT OF A CANCER IN WHICH IS THYMINE DNA GLYCOSYLASE EXPRESSED
  申请人：Institute For Cancer Research D/b/a The Research Institute of Fox Chase Cancer Center

  公开号：EP3052655B1

  公开（公告）日：2018-11-07
• TREATMENT OF INFLAMMATORY DISEASE USING CAVEOLIN LINKED TO AN INTERNALISATION PEPTIDE
  申请人：E & B Technologies LLC

  公开号：EP3074034B1

  公开（公告）日：2019-05-01