sodium;2-hydroxybenzoate;[(E)-(3-hydroxy-1-methyl-6-oxo-2,3-dihydroindol-5-ylidene)amino]urea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: sodium;2-hydroxybenzoate;[(E)-(3-hydroxy-1-methyl-6-oxo-2,3-dihydroindol-5-ylidene)amino]urea
• 化学式: C17H17N4NaO6
• 分子量: 396.3
• InChiKey: CELKBRMLNUNCIP-HTFHIHPASA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -4.53
• 重原子数：
  28
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  168
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Nitric Oxide Releasing Prodrugs of Therapeutic Agents
  申请人：SATYAM Apparao

  公开号：US20110263526A1

  公开（公告）日：2011-10-27

  The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents which are represented herein as compounds of formula (I) wherein the drugs or therapeutic agents contain one or more functional groups independently selected from a carboxylic acid, an amino, a hydroxyl and a sulfhydryl group. The invention also relates to processes for the preparation of the nitric oxide releasing prodrugs (the compounds of formula (I)), to pharmaceutical compositions containing them and to methods of using the prodrugs.

  本发明涉及已知药物或治疗剂的一氧化氮释放前药，其在此处表示为式(I)的化合物，其中药物或治疗剂包含一个或多个功能基团，独立地选自羧酸、氨基、羟基和巯基。该发明还涉及制备一氧化氮释放前药（式(I)的化合物）的方法，含有它们的药物组合物以及使用这些前药的方法。
• Apparatus and method for marking tissue
  申请人：ETHICON ENDO-SURGERY, INC.

  公开号：EP1579878A1

  公开（公告）日：2005-09-28

  The present invention includes methods and materials for implantable devices (markers) which are disclosed for permanently marking the location of a biopsy or surgery for the purpose of identification. The devices are remotely delivered, preferably percutaneously. Visualization of the markers is readily accomplished using various state of the art imaging systems. Preferred visualization is through MRI, X-ray and ultrasound. The markers function to provide evidence of the location of the lesion after the procedure is complete for reference during future examinations or procedures.

  本发明包括可植入装置（标记物）的方法和材料，这些装置用于永久标记活检或手术的位置，以便识别。这些装置可远程投放，最好是经皮投放。标记的可视化可通过各种最先进的成像系统轻松实现。最好通过核磁共振成像、X 射线和超声波进行观察。标记的作用是在手术完成后提供病变位置的证据，供今后检查或手术时参考。
• Cavity-filling biopsy site markers
  申请人：——

  公开号：US20020188196A1

  公开（公告）日：2002-12-12

  The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome® or SenoCor 360™ cannula.

  本发明提供了在有限时间内标记活检部位的材料、装置和方法。活检标记材料是超声波可检测的生物可吸收粉末，粉末颗粒的最大尺寸通常在约 20 微米至约 800 微米之间，更优选约 300 微米至约 500 微米之间。粉末可由聚合材料形成，含有尺寸在约 10 微米至约 500 微米之间的空腔，还可含有结合剂、麻醉剂、止血剂和不透射线标记物。输送粉末的装置包括用于容纳粉末并与活检插管相配合的管子，粉末在注射器的作用下喷出。系统可包括一个装有粉末的管子和一个装有无菌生理盐水的注射器。管子可以配置成适合于活检插管，如 Mammotome® 或 SenoCor 360™ 插管。
• Use of hyaluronic acid derivatives in the preparation of biomaterials with a physical haemostatic and plugging activity and a preventive activity in the formation of adhesions following anastomosis
  申请人：——

  公开号：US20030060448A1

  公开（公告）日：2003-03-27

  The present invention describes the use of polysaccharide derivatives for the preparation of biocompatible and biodegradable biomaterials with absorbent properties for body fluids and physical hemostatic activity, to be used in both venous and arterial vascular anastomoses to create a physical hemostatic barrier and to prevent scar tissue formation and formation of post-surgical adherence of the vessels to the surrounding tissues.

  本发明描述了使用多糖衍生物制备具有体液吸收特性和物理止血活性的生物相容性和可生物降解的生物材料，用于静脉和动脉血管吻合，以形成物理止血屏障，防止瘢痕组织形成和手术后血管与周围组织的粘连。
• Method and device for tissue removal and for delivery of a therapeutic agent or bulking agent
  申请人：Li (Jianmin) Jamie

  公开号：US20060253069A1

  公开（公告）日：2006-11-09

  According to an aspect of the present invention, a medical device is provided, which comprises the following: (a) a hollow elongate body (e.g., a elongate cylinder, such as a needle) having distal and proximal ends; and (b) a rotatable member comprising a tissue morselizer and an elongate shaft (e.g., an auger-like tissue-drilling bit). In the devices of the present invention, the elongate shaft is disposed within the hollow elongate body and cooperates with the hollow elongate body to (i) advance material (e.g., morselated tissue) toward the proximal end of the hollow elongate body when the shaft is rotated in a first direction, and (ii) advance material (e.g., a therapeutic agent and/or a bulking agent) toward the distal end of the hollow elongate body when the shaft is rotated in a second direction that is opposite the first direction. According to another aspect of the invention a method of treatment is provided that comprises: (a) inserting the a medical device like that above into the tissue of a patient; (b) morselizing and removing tissue from within the patient while rotating the shaft in a first direction, thereby creating a void within the patient; and (c) introducing a therapeutic agent and/or a bulking agent into the void.

  根据本发明的一个方面，提供了一种医疗器械，它包括以下部分：(a) 具有远端和近端的中空细长体（例如，细长圆柱体，如针头）；以及 (b) 可旋转部件，包括组织咀嚼器和细长轴（例如，螺旋状组织钻头）。在本发明的设备中，细长轴设置在中空细长体内，并与中空细长体配合，以便：(i) 当轴沿第一方向旋转时，将材料（例如，切碎的组织）推向中空细长体的近端；(ii) 当轴沿与第一方向相反的第二方向旋转时，将材料（例如，治疗剂和/或膨松剂）推向中空细长体的远端。根据本发明的另一方面，提供了一种治疗方法，该方法包括：(a) 将类似上述的医疗器械插入患者的组织中；(b) 在沿第一方向旋转轴的同时，从患者体内切除组织，从而在患者体内形成空隙；(c) 将治疗剂和/或增容剂引入空隙中。