N-[(E)-1-pyridin-2-ylethylideneamino]-[1,3]thiazolo[5,4-b]pyridin-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-[(E)-1-pyridin-2-ylethylideneamino]-[1,3]thiazolo[5,4-b]pyridin-2-amine
• 化学式: C₁₃H₁₁N₅S
• 分子量: 269.33
• InChiKey: ANMRRQRSIVOLHB-RQZCQDPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  91.3
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• SMALL MOLECULE REGULATORS OF STEROID RECEPTOR COACTIVATORS AND METHODS OF USE THEREOF
  申请人：BAYLOR COLLEGE OF MEDICINE

  公开号：US20170290830A1

  公开（公告）日：2017-10-12

  Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing SRC-related diseases. The SRC-related diseases can include cancer, metabolic disorders, human immunodeficiency virus, neurodegenerative disorders, and/or inflammatory diseases. Also provided are methods for regulating SRC family proteins in a cell.

  提供了小分子调节类固醇受体共激活子（SRC）家族蛋白的方法，以及它们在治疗或预防SRC相关疾病中的应用。SRC相关疾病可以包括癌症、代谢紊乱、人类免疫缺陷病毒、神经退行性疾病和/或炎症性疾病。还提供了在细胞中调节SRC家族蛋白的方法。
• Small molecule regulators of steroid receptor coactivators and methods of use thereof
  申请人：BAYLOR COLLEGE OF MEDICINE

  公开号：US10265315B2

  公开（公告）日：2019-04-23

  Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing SRC-related diseases. The SRC-related diseases can include cancer, metabolic disorders, human immunodeficiency virus, neurodegenerative disorders, and/or inflammatory diseases. Also provided are methods for regulating SRC family proteins in a cell.

  本研究提供了类固醇受体辅激活剂（SRC）家族蛋白的小分子调节剂，以及将其用于治疗或预防 SRC 相关疾病的方法。SRC 相关疾病可包括癌症、代谢紊乱、人类免疫缺陷病毒、神经退行性疾病和/或炎症性疾病。还提供了调节细胞中SRC家族蛋白的方法。